FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3114446520> ?p ?o ?g. }

• W3114446520 abstract "Moriche palm is consumed as both a fresh fruit and processed food in Peru and Brazil. Although its fruit contains phytoestrogens, the active compounds have not yet been identified. Therefore, we purified moriche palm extract (MPE) and identified compounds exhibiting estrogenic and antiandrogenic activities. Estrogenic activity was assessed by the estrogen-dependent growth of MCF-7 cells and increases in uterine weights in mice. Antiandrogenic activity was evaluated by 5α-reductase inhibitory activity and prostate-specific antigen (PSA) expression in LNCaP cells. In vivo antiestrogenic activity was also assessed based on testosterone-induced prostate growth in castrated mice. Four methoxyflavans were isolated from MPE and all, except for 7,4'-dihydroxy-5-methoxyflavan, promoted MCF-7 cell growth, indicating estrogenic activity. Uterine and ovary weights increased in mice orally administered MPE (400 mg/kg) for 2 weeks. Regarding antiandrogenic activity, among the four methoxyflavans isolated, 6,7,4'-trihydroxy-5-methoxyflavan (1 µg/ml) suppressed the mRNA and protein expression of PSA in LNCaP cells. Furthermore, prostate growth was suppressed in mice orally administered MPE (200 mg/kg) for 2 weeks. All methoxyflavans inhibited 5α-reductase activity with IC50 less than 10 µg/ml. Collectively, the present results demonstrated that orally administered MPE exhibited estrogenic and antiandrogenic activities. Methoxyflavans, particularly 6,7,4'-trihydroxy-5-methoxyflavan, appear to be the active compounds for these activities. PRACTICAL APPLICATIONS: The fruit of Mauritia flexuosa (moriche palm) has been used for beverages and processed foods. Although it is said to contain phytoestrogens, the active compounds have not yet been identified. In this study, we isolated and identified methoxyflavans exhibiting estrogenic and antiandrogenic activities. Among them, 6,7,4'-trihydroxy-5-methoxyflavan appeared to be the most effective compounds for these activities." @default.
• W3114446520 created "2021-01-05" @default.
• W3114446520 creator A5035839283 @default.
• W3114446520 creator A5036719255 @default.
• W3114446520 creator A5038527629 @default.
• W3114446520 creator A5050342197 @default.
• W3114446520 creator A5087445208 @default.
• W3114446520 date "2020-12-19" @default.
• W3114446520 modified "2023-10-17" @default.
• W3114446520 title "Estrogenic and antiandrogenic activities of methoxyflavans isolated from the fruit of <i>Mauritia Flexuosa</i> (Moriche Palm)" @default.
• W3114446520 cites W1512005330 @default.
• W3114446520 cites W1983563158 @default.
• W3114446520 cites W2019273611 @default.
• W3114446520 cites W2020396959 @default.
• W3114446520 cites W2021485462 @default.
• W3114446520 cites W2026388454 @default.
• W3114446520 cites W2033194199 @default.
• W3114446520 cites W2067948296 @default.
• W3114446520 cites W2078715315 @default.
• W3114446520 cites W2078978712 @default.
• W3114446520 cites W2089821948 @default.
• W3114446520 cites W2092087913 @default.
• W3114446520 cites W2102549077 @default.
• W3114446520 cites W2108926417 @default.
• W3114446520 cites W2109612055 @default.
• W3114446520 cites W2116053580 @default.
• W3114446520 cites W2126494998 @default.
• W3114446520 cites W2133797225 @default.
• W3114446520 cites W2137552990 @default.
• W3114446520 cites W2142542116 @default.
• W3114446520 cites W2144630072 @default.
• W3114446520 cites W2153544617 @default.
• W3114446520 cites W2160121739 @default.
• W3114446520 cites W2198863409 @default.
• W3114446520 cites W2501480322 @default.
• W3114446520 cites W2541326353 @default.
• W3114446520 cites W2728560521 @default.
• W3114446520 cites W2775150992 @default.
• W3114446520 cites W2907364241 @default.
• W3114446520 cites W2918075623 @default.
• W3114446520 cites W2925795344 @default.
• W3114446520 cites W2972497746 @default.
• W3114446520 doi "https://doi.org/10.1111/jfbc.13583" @default.
• W3114446520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33340139" @default.
• W3114446520 hasPublicationYear "2020" @default.
• W3114446520 type Work @default.
• W3114446520 sameAs 3114446520 @default.
• W3114446520 citedByCount "2" @default.
• W3114446520 countsByYear W31144465202022 @default.
• W3114446520 countsByYear W31144465202023 @default.
• W3114446520 crossrefType "journal-article" @default.
• W3114446520 hasAuthorship W3114446520A5035839283 @default.
• W3114446520 hasAuthorship W3114446520A5036719255 @default.
• W3114446520 hasAuthorship W3114446520A5038527629 @default.
• W3114446520 hasAuthorship W3114446520A5050342197 @default.
• W3114446520 hasAuthorship W3114446520A5087445208 @default.
• W3114446520 hasBestOaLocation W31144465201 @default.
• W3114446520 hasConcept C121332964 @default.
• W3114446520 hasConcept C185592680 @default.
• W3114446520 hasConcept C556039675 @default.
• W3114446520 hasConcept C59822182 @default.
• W3114446520 hasConcept C62520636 @default.
• W3114446520 hasConcept C71924100 @default.
• W3114446520 hasConcept C86803240 @default.
• W3114446520 hasConcept C94598645 @default.
• W3114446520 hasConceptScore W3114446520C121332964 @default.
• W3114446520 hasConceptScore W3114446520C185592680 @default.
• W3114446520 hasConceptScore W3114446520C556039675 @default.
• W3114446520 hasConceptScore W3114446520C59822182 @default.
• W3114446520 hasConceptScore W3114446520C62520636 @default.
• W3114446520 hasConceptScore W3114446520C71924100 @default.
• W3114446520 hasConceptScore W3114446520C86803240 @default.
• W3114446520 hasConceptScore W3114446520C94598645 @default.
• W3114446520 hasIssue "1" @default.
• W3114446520 hasLocation W31144465201 @default.
• W3114446520 hasOpenAccess W3114446520 @default.
• W3114446520 hasPrimaryLocation W31144465201 @default.
• W3114446520 hasRelatedWork W1531601525 @default.
• W3114446520 hasRelatedWork W2384464875 @default.
• W3114446520 hasRelatedWork W2606230654 @default.
• W3114446520 hasRelatedWork W2607424097 @default.
• W3114446520 hasRelatedWork W2748952813 @default.
• W3114446520 hasRelatedWork W2899084033 @default.
• W3114446520 hasRelatedWork W2948807893 @default.
• W3114446520 hasRelatedWork W3215139134 @default.
• W3114446520 hasRelatedWork W4387497383 @default.
• W3114446520 hasRelatedWork W2778153218 @default.
• W3114446520 hasVolume "45" @default.
• W3114446520 isParatext "false" @default.
• W3114446520 isRetracted "false" @default.
• W3114446520 magId "3114446520" @default.
• W3114446520 workType "article" @default.