FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3114509328> ?p ?o ?g. }

• W3114509328 endingPage "2059" @default.
• W3114509328 startingPage "2046" @default.
• W3114509328 abstract "Uterine leiomyosarcoma (LMS) is a rare but deadly disease. Due to poor understanding of the molecular and genetic causes of the disease, the diagnosis of LMS has been based primarily on histology. Nuclear atypia is one of hallmarks in LMS however, it also occurs in two clinically benign variants, including smooth muscle tumors with fumarate hydratase alteration (SMT-FH) and leiomyoma with bizarre nuclei (LM-BN). In addition to nuclear atypia, many well-recognized biomarkers used for LMS are also frequently overexpressed in LM-BN and,the histogenesis and molecular natures for LM-BN and LMS remains largely unknown. To characterize the molecular profiling of LMS, SMT-FH and LM-BN, we performed integrated comprehensive genomic profiling including whole genome sequencing (WGS) and RNA-sequencing and genomic microarray analyses to assess genome-wide copy number alterations (CNAs) and immunohistochemistry (IHC) in all three tumor types. We found that both LM-BN and LMS showed genomic instability and harbored extensive CNAs throughout the whole genome. By contrast, the SMT-FH presented its characteristic 1q43-44 deletions in all cases tested, with minimal CNAs in the rest of genomic regions. Further analyses revealed that LMS and LM-BN groups showed similar patterns of CNAs that are tended to cluster together and separated from the SMT-FH group. The integrated molecular profiling enabled detections of novel and traditional biomarkers and showed excellent discrimination between LM-BN and LMS. Our study suggests that LM-BN, despite having similar nuclear atypia to SMT-FH, shows similar genomic instability but distinct genomic alterations with its malignant counterpart of LMS. The integrated molecular profiling is of clinical importance in characterizing these rare uterine smooth muscle tumors." @default.
• W3114509328 created "2021-01-05" @default.
• W3114509328 creator A5009298625 @default.
• W3114509328 creator A5030528829 @default.
• W3114509328 creator A5046786928 @default.
• W3114509328 creator A5054068214 @default.
• W3114509328 creator A5057077440 @default.
• W3114509328 creator A5060818696 @default.
• W3114509328 creator A5061013941 @default.
• W3114509328 creator A5079147453 @default.
• W3114509328 creator A5085229257 @default.
• W3114509328 date "2021-03-22" @default.
• W3114509328 modified "2023-10-16" @default.
• W3114509328 title "Integrated histologic and molecular analysis of uterine leiomyosarcoma and 2 benign variants with nuclear atypia" @default.
• W3114509328 cites W1503909240 @default.
• W3114509328 cites W1617495083 @default.
• W3114509328 cites W1964185292 @default.
• W3114509328 cites W1970204938 @default.
• W3114509328 cites W1974567967 @default.
• W3114509328 cites W1978250292 @default.
• W3114509328 cites W1980682695 @default.
• W3114509328 cites W1985379210 @default.
• W3114509328 cites W1994715774 @default.
• W3114509328 cites W1998734250 @default.
• W3114509328 cites W2000095508 @default.
• W3114509328 cites W2006617902 @default.
• W3114509328 cites W2023317907 @default.
• W3114509328 cites W2025112578 @default.
• W3114509328 cites W2031391627 @default.
• W3114509328 cites W2053015113 @default.
• W3114509328 cites W2056828732 @default.
• W3114509328 cites W2063439260 @default.
• W3114509328 cites W2073934717 @default.
• W3114509328 cites W2079013375 @default.
• W3114509328 cites W2089554929 @default.
• W3114509328 cites W2091734792 @default.
• W3114509328 cites W2092518241 @default.
• W3114509328 cites W2121708869 @default.
• W3114509328 cites W2121963546 @default.
• W3114509328 cites W2157852151 @default.
• W3114509328 cites W2168754435 @default.
• W3114509328 cites W2178443118 @default.
• W3114509328 cites W2323684649 @default.
• W3114509328 cites W2326661743 @default.
• W3114509328 cites W2400586155 @default.
• W3114509328 cites W2462996768 @default.
• W3114509328 cites W2725434552 @default.
• W3114509328 cites W2736069787 @default.
• W3114509328 cites W2751120996 @default.
• W3114509328 cites W2765468373 @default.
• W3114509328 cites W2766493195 @default.
• W3114509328 cites W2782477516 @default.
• W3114509328 cites W2946750115 @default.
• W3114509328 cites W2970240482 @default.
• W3114509328 cites W2971366750 @default.
• W3114509328 cites W4231937810 @default.
• W3114509328 cites W4294541781 @default.
• W3114509328 doi "https://doi.org/10.1111/cas.14775" @default.
• W3114509328 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8088951" @default.
• W3114509328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33338329" @default.
• W3114509328 hasPublicationYear "2021" @default.
• W3114509328 type Work @default.
• W3114509328 sameAs 3114509328 @default.
• W3114509328 citedByCount "7" @default.
• W3114509328 countsByYear W31145093282021 @default.
• W3114509328 countsByYear W31145093282022 @default.
• W3114509328 countsByYear W31145093282023 @default.
• W3114509328 crossrefType "journal-article" @default.
• W3114509328 hasAuthorship W3114509328A5009298625 @default.
• W3114509328 hasAuthorship W3114509328A5030528829 @default.
• W3114509328 hasAuthorship W3114509328A5046786928 @default.
• W3114509328 hasAuthorship W3114509328A5054068214 @default.
• W3114509328 hasAuthorship W3114509328A5057077440 @default.
• W3114509328 hasAuthorship W3114509328A5060818696 @default.
• W3114509328 hasAuthorship W3114509328A5061013941 @default.
• W3114509328 hasAuthorship W3114509328A5079147453 @default.
• W3114509328 hasAuthorship W3114509328A5085229257 @default.
• W3114509328 hasBestOaLocation W31145093281 @default.
• W3114509328 hasConcept C142724271 @default.
• W3114509328 hasConcept C204232928 @default.
• W3114509328 hasConcept C2777532014 @default.
• W3114509328 hasConcept C2781283455 @default.
• W3114509328 hasConcept C2781289014 @default.
• W3114509328 hasConcept C71924100 @default.
• W3114509328 hasConceptScore W3114509328C142724271 @default.
• W3114509328 hasConceptScore W3114509328C204232928 @default.
• W3114509328 hasConceptScore W3114509328C2777532014 @default.
• W3114509328 hasConceptScore W3114509328C2781283455 @default.
• W3114509328 hasConceptScore W3114509328C2781289014 @default.
• W3114509328 hasConceptScore W3114509328C71924100 @default.
• W3114509328 hasIssue "5" @default.
• W3114509328 hasLocation W31145093281 @default.
• W3114509328 hasLocation W31145093282 @default.
• W3114509328 hasOpenAccess W3114509328 @default.
• W3114509328 hasPrimaryLocation W31145093281 @default.
• W3114509328 hasRelatedWork W2009989290 @default.
• W3114509328 hasRelatedWork W2035148703 @default.
• W3114509328 hasRelatedWork W2053358398 @default.

• next