Matches in SemOpenAlex for { <https://semopenalex.org/work/W3114528423> ?p ?o ?g. }
- W3114528423 abstract "Human leukocyte antigen-G (HLA-G) is a non-classical major histocompatibility complex class I (MHC I) molecule, and under physiological conditions, its expression is strictly restricted to the maternal–fetal interface and immune-privileged organs where HLA-G is expected to contribute to establishment and maintenance of immune tolerance. However, the expression of HLA-G has been found in various types of tumors, and the level of its expression frequently correlates with high-grade histology and poor prognosis, raising the possibility that it may play a negative role in tumor immunity. ILT2 and ILT4, present on a broad of immune cells, have been identified as the main receptors engaging HLA-G, and their interactions have been found to allow the conversion of effectors like NK cells and T cells to anergic or unresponsive state, activated DCs to tolerogenic state, and to drive the differentiation of T cells toward suppressive phenotype. Therefore, tumors can employ HLA-G to modulate the phenotype and function of immune cells, allowing them to escape immune attack. In this review, we discuss the mechanism underlying HLA-G expression and function, its role played in each step of the tumor-immunity cycle, as well as the potential to target it for therapeutic benefit." @default.
- W3114528423 created "2021-01-05" @default.
- W3114528423 creator A5014774337 @default.
- W3114528423 creator A5024591012 @default.
- W3114528423 creator A5049264813 @default.
- W3114528423 creator A5061687324 @default.
- W3114528423 creator A5062418787 @default.
- W3114528423 date "2020-12-23" @default.
- W3114528423 modified "2023-10-12" @default.
- W3114528423 title "The Role of HLA-G in Tumor Escape: Manipulating the Phenotype and Function of Immune Cells" @default.
- W3114528423 cites W1506551612 @default.
- W3114528423 cites W1585977107 @default.
- W3114528423 cites W1605315426 @default.
- W3114528423 cites W1757059946 @default.
- W3114528423 cites W1882502102 @default.
- W3114528423 cites W1965780550 @default.
- W3114528423 cites W1966273058 @default.
- W3114528423 cites W1967035409 @default.
- W3114528423 cites W1967263426 @default.
- W3114528423 cites W1968550069 @default.
- W3114528423 cites W1970410047 @default.
- W3114528423 cites W1973193045 @default.
- W3114528423 cites W1973284702 @default.
- W3114528423 cites W1973675832 @default.
- W3114528423 cites W1976696463 @default.
- W3114528423 cites W1977176164 @default.
- W3114528423 cites W1978295388 @default.
- W3114528423 cites W1978459180 @default.
- W3114528423 cites W1979253523 @default.
- W3114528423 cites W1979727824 @default.
- W3114528423 cites W1981566776 @default.
- W3114528423 cites W1985385053 @default.
- W3114528423 cites W1990412862 @default.
- W3114528423 cites W1994937984 @default.
- W3114528423 cites W1996787721 @default.
- W3114528423 cites W1997994653 @default.
- W3114528423 cites W2001157494 @default.
- W3114528423 cites W2002982888 @default.
- W3114528423 cites W2003939651 @default.
- W3114528423 cites W2004771808 @default.
- W3114528423 cites W2008761663 @default.
- W3114528423 cites W2008865603 @default.
- W3114528423 cites W2009328663 @default.
- W3114528423 cites W2012671068 @default.
- W3114528423 cites W2015650992 @default.
- W3114528423 cites W2020194440 @default.
- W3114528423 cites W2021582501 @default.
- W3114528423 cites W2021902701 @default.
- W3114528423 cites W2026053348 @default.
- W3114528423 cites W2029175700 @default.
- W3114528423 cites W2030678127 @default.
- W3114528423 cites W2031509003 @default.
- W3114528423 cites W2031913314 @default.
- W3114528423 cites W2035155248 @default.
- W3114528423 cites W2039339794 @default.
- W3114528423 cites W2042159479 @default.
- W3114528423 cites W2042724189 @default.
- W3114528423 cites W2043731481 @default.
- W3114528423 cites W2044435667 @default.
- W3114528423 cites W2047056707 @default.
- W3114528423 cites W2049736644 @default.
- W3114528423 cites W2055760702 @default.
- W3114528423 cites W2056828169 @default.
- W3114528423 cites W2057024445 @default.
- W3114528423 cites W2059841890 @default.
- W3114528423 cites W2062163694 @default.
- W3114528423 cites W2064140853 @default.
- W3114528423 cites W2066639195 @default.
- W3114528423 cites W2067720485 @default.
- W3114528423 cites W2069197942 @default.
- W3114528423 cites W2071704959 @default.
- W3114528423 cites W2072974626 @default.
- W3114528423 cites W2079136653 @default.
- W3114528423 cites W2088514265 @default.
- W3114528423 cites W2088974691 @default.
- W3114528423 cites W2090887099 @default.
- W3114528423 cites W2105267515 @default.
- W3114528423 cites W2108463809 @default.
- W3114528423 cites W2108848387 @default.
- W3114528423 cites W2113007586 @default.
- W3114528423 cites W2113047034 @default.
- W3114528423 cites W2116277860 @default.
- W3114528423 cites W2116650389 @default.
- W3114528423 cites W2124683381 @default.
- W3114528423 cites W2127924037 @default.
- W3114528423 cites W2132924631 @default.
- W3114528423 cites W2135978944 @default.
- W3114528423 cites W2136143495 @default.
- W3114528423 cites W2142982199 @default.
- W3114528423 cites W2158829408 @default.
- W3114528423 cites W2161442070 @default.
- W3114528423 cites W2166126168 @default.
- W3114528423 cites W2169266581 @default.
- W3114528423 cites W2201063291 @default.
- W3114528423 cites W2789996188 @default.
- W3114528423 cites W2853603805 @default.
- W3114528423 cites W2886607802 @default.
- W3114528423 cites W2893223637 @default.
- W3114528423 cites W2898382408 @default.
- W3114528423 cites W2971019999 @default.