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• W3114593569 abstract "Cytoprotective mechanisms of heme oxygenases function by derivatizing heme to generate carbon monoxide, ferrous iron, and isomeric biliverdins, followed by rapid NAD(P)H-dependent biliverdin reduction to the antioxidant bilirubin using two non-overlapping biliverdin reductases that display biliverdin isomer-restricted redox activity. Although cytoprotective functions of heme oxygenases are widely recognized, concomitant effects of downstream biliverdin reductases remain incomplete. A computational model predicated on murine hematopoietic single-cell transcriptomic data identified Blvrb as a biological driver linked to the tumor necrosis factor stress pathway as a predominant source of variation defining hematopoietic cell heterogeneity. In vivo studies using Blvrb-deficient mice established the dispensable role of Blvrb in steady-state hematopoiesis, although model validation using aged Blvrb-deficient mice established an important cytoprotective function in stress hematopoiesis with dichotomous megakaryocyte-biased hematopoietic recovery. Defective stress erythropoiesis was evident in Blvrb-/- spleens and in bone marrow erythroid development, occurring in conjunction with defective lipid peroxidation as a marker of oxidant mishandling. Cell autonomous effects on megakaryocyte lineage bias were documented using multipotential progenitor assays. These data provide the first physiological function of murine Blvrb in a non-redundant pathway of stress cytoprotection. Divergent effects on erythroid/megakaryocyte lineage speciation impute a novel redox-regulated mechanism for lineage partitioning." @default.
• W3114593569 created "2021-01-05" @default.
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• W3114593569 date "2021-02-01" @default.
• W3114593569 modified "2023-09-26" @default.
• W3114593569 title "Divergent erythroid megakaryocyte fates in Blvrb-deficient mice establish non-overlapping cytoprotective functions during stress hematopoiesis" @default.
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• W3114593569 cites W1586487499 @default.
• W3114593569 cites W1787222452 @default.
• W3114593569 cites W190906149 @default.
• W3114593569 cites W1950905025 @default.
• W3114593569 cites W1966582616 @default.
• W3114593569 cites W1973142979 @default.
• W3114593569 cites W1973466019 @default.
• W3114593569 cites W1980148430 @default.
• W3114593569 cites W1987547894 @default.
• W3114593569 cites W1987777210 @default.
• W3114593569 cites W1995091371 @default.
• W3114593569 cites W2001019228 @default.
• W3114593569 cites W2002426440 @default.
• W3114593569 cites W2006938530 @default.
• W3114593569 cites W2010457001 @default.
• W3114593569 cites W2018356558 @default.
• W3114593569 cites W2021443072 @default.
• W3114593569 cites W2024142426 @default.
• W3114593569 cites W2025656277 @default.
• W3114593569 cites W2027427419 @default.
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• W3114593569 cites W2036864051 @default.
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• W3114593569 cites W2041352553 @default.
• W3114593569 cites W2042859522 @default.
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• W3114593569 cites W2079822043 @default.
• W3114593569 cites W2085544097 @default.
• W3114593569 cites W2095183407 @default.
• W3114593569 cites W2096364098 @default.
• W3114593569 cites W2099540110 @default.
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• W3114593569 cites W2398260339 @default.
• W3114593569 cites W2465917013 @default.
• W3114593569 cites W2475265013 @default.
• W3114593569 cites W2547550880 @default.
• W3114593569 cites W2558789531 @default.
• W3114593569 cites W2735731274 @default.
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• W3114593569 doi "https://doi.org/10.1016/j.freeradbiomed.2020.12.015" @default.
• W3114593569 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8311568" @default.
• W3114593569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33359909" @default.
• W3114593569 hasPublicationYear "2021" @default.
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