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- W3114633850 abstract "Clonorchiasis caused by Clonorchis sinensis is endemic in East Asia; approximately 15 million people have been infected thus far. To diagnose the infection, serodiagnostic tests with excellent functionality should be performed. First, 607 expressed sequence tags encoding polypeptides with a secretory signal were expressed into recombinant proteins using an in vitro translation system. By protein array-based screening using C . sinensis -infected sera, 18 antigen candidate proteins were selected and assayed for cross-reactivity against Opisthorchis viverrini -infected sera. Of the six antigenic proteins selected, four were synthesized on large scale in vitro and evaluated for antigenicity against the flukes-infected human sera using ELISA. CsAg17 antigen showed the highest sensitivity (77.1%) and specificity (71.2%). The sensitivity and specificity of the bacterially produced CsAg17-28GST fusion antigen was similar to those of CsAg17 antigen. CsAg17 antigen can be used to develop point-of-care serodiagnostic tests for clonorchiasis." @default.
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- W3114633850 date "2020-12-28" @default.
- W3114633850 modified "2023-10-16" @default.
- W3114633850 title "Serodiagnostic antigens of Clonorchis sinensis identified and evaluated by high-throughput proteogenomics" @default.
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- W3114633850 doi "https://doi.org/10.1371/journal.pntd.0008998" @default.
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