Matches in SemOpenAlex for { <https://semopenalex.org/work/W3114693742> ?p ?o ?g. }
- W3114693742 abstract "Different subsets of the tRNA pool in human cells are expressed in different cellular conditions. The ‘proliferation-tRNAs’ are induced upon normal and cancerous cell division, while the ‘differentiation-tRNAs’ are active in non-dividing, differentiated cells. Here we examine the essentiality of the various tRNAs upon cellular growth and arrest. We established a CRISPR-based editing procedure with sgRNAs that each target a tRNA family. We measured tRNA essentiality for cellular growth and found that most proliferation-tRNAs are essential compared to differentiation- tRNAs in rapidly growing cell lines. Yet in more slowly dividing lines, the differentiation-tRNAs were more essential. In addition, we measured the essentiality of each tRNA family upon response to cell cycle arresting signals. Here we detected a more complex behavior with both proliferation-tRNAs and differentiation tRNAs showing various levels of essentiality. These results provide the so-far most comprehensive functional characterization of human tRNAs with intricate roles in various cellular states." @default.
- W3114693742 created "2021-01-05" @default.
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- W3114693742 date "2020-12-24" @default.
- W3114693742 modified "2023-10-16" @default.
- W3114693742 title "Manipulation of the human tRNA pool reveals distinct tRNA sets that act in cellular proliferation or cell cycle arrest" @default.
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- W3114693742 doi "https://doi.org/10.7554/elife.58461" @default.
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- W3114693742 hasPublicationYear "2020" @default.
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