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- W3114702450 abstract "Significance Adenoviruses (AdVs) are DNA viruses that can cause severe respiratory illness in humans. A better understanding of the complex ways AdVs utilize cellular processes in service of their replication is critical to the development of new therapies to counter viral infection and disease. Using a genome-wide screen, we identified a cellular protein Mindbomb 1 (MIB1) required for AdV infection and show that it functions in the AdV entry process to mediate release of the viral genome into the nucleus. We further show that MIB1, as an E3 ubiquitin ligase, mediates AdV capsid disassembly and genome release through ubiquitination of a target protein(s), demonstrating the importance of this rapid posttranslational modification to virus infection." @default.
- W3114702450 created "2021-01-05" @default.
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- W3114702450 date "2020-12-28" @default.
- W3114702450 modified "2023-09-30" @default.
- W3114702450 title "E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes" @default.
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- W3114702450 doi "https://doi.org/10.1073/pnas.2015794118" @default.
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