Matches in SemOpenAlex for { <https://semopenalex.org/work/W3114807730> ?p ?o ?g. }
- W3114807730 endingPage "35" @default.
- W3114807730 startingPage "35" @default.
- W3114807730 abstract "On the basis of fungal involvement, rhinosinusitis is categorized into allergic, mycetoma, chronic, and acute invasive types. The aim of the current study was to evaluate the efficacy of an amphotericin gel in situ loaded with nanotransferosomes against Aspergillus flavus, which causes allergic rhinosinusitis. A Box–Behnken design was utilized to study the interaction among the nanotransferosomes and optimize independent variables in formulating them, in order to match the prerequisites of selected responses. The optimal formulation was determined to be 300 mg/mL soybean lecithin, 200 mg/mL amphotericin B (AMP), and 150 mg/mL clove oil, resulting in a particle size of 155.09 nm, 84.30% entrapment efficacy (EE), inhibition zone of 16.0 mm, and 0.1197 mmol serum creatinine. The optimized batch was further prepared into an in situ gel and evaluated for various parameters. The optimized formulation released 79.25% AMP and enhanced permeation through the nasal membrane, while the other formulations did not achieve complete absorption. According to in vivo tests using rabbits as animal models, the optimized AMP-nanotransferosomal formulations (NT) in in situ gel result in a non-significant difference among the various kidney function parameters. In conclusion, nasal in situ gel loaded with AMP-clove oil nanotreansfersomes can act as a promising novel carrier that enhances antifungal activity and decreases AMP nephrotoxicity." @default.
- W3114807730 created "2021-01-05" @default.
- W3114807730 creator A5014649653 @default.
- W3114807730 creator A5063060227 @default.
- W3114807730 date "2020-12-28" @default.
- W3114807730 modified "2023-09-26" @default.
- W3114807730 title "Nasal Gel Loaded with Amphotericin Nanotransferosomes as Antifungal Treatment for Fungal Sinusitis" @default.
- W3114807730 cites W1969406534 @default.
- W3114807730 cites W1977237832 @default.
- W3114807730 cites W1986557490 @default.
- W3114807730 cites W1986970931 @default.
- W3114807730 cites W1987088781 @default.
- W3114807730 cites W1991071923 @default.
- W3114807730 cites W1992527461 @default.
- W3114807730 cites W2002891752 @default.
- W3114807730 cites W2004957965 @default.
- W3114807730 cites W2011184697 @default.
- W3114807730 cites W2020995840 @default.
- W3114807730 cites W2034792164 @default.
- W3114807730 cites W2035108099 @default.
- W3114807730 cites W2039748268 @default.
- W3114807730 cites W2046810515 @default.
- W3114807730 cites W2048967489 @default.
- W3114807730 cites W2049024926 @default.
- W3114807730 cites W2052483378 @default.
- W3114807730 cites W2053825412 @default.
- W3114807730 cites W2057141276 @default.
- W3114807730 cites W2057948801 @default.
- W3114807730 cites W2058328127 @default.
- W3114807730 cites W2058656038 @default.
- W3114807730 cites W2062349526 @default.
- W3114807730 cites W2082048799 @default.
- W3114807730 cites W2085496520 @default.
- W3114807730 cites W2094677265 @default.
- W3114807730 cites W2155151355 @default.
- W3114807730 cites W2165823082 @default.
- W3114807730 cites W2166750946 @default.
- W3114807730 cites W2170666105 @default.
- W3114807730 cites W2185344023 @default.
- W3114807730 cites W2195655326 @default.
- W3114807730 cites W2298912458 @default.
- W3114807730 cites W2317256715 @default.
- W3114807730 cites W2409663752 @default.
- W3114807730 cites W2468231541 @default.
- W3114807730 cites W2789244501 @default.
- W3114807730 cites W2790036073 @default.
- W3114807730 cites W2925234427 @default.
- W3114807730 cites W2969378308 @default.
- W3114807730 cites W3011074674 @default.
- W3114807730 cites W3015383652 @default.
- W3114807730 doi "https://doi.org/10.3390/pharmaceutics13010035" @default.
- W3114807730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7824183" @default.
- W3114807730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33379314" @default.
- W3114807730 hasPublicationYear "2020" @default.
- W3114807730 type Work @default.
- W3114807730 sameAs 3114807730 @default.
- W3114807730 citedByCount "2" @default.
- W3114807730 countsByYear W31148077302021 @default.
- W3114807730 countsByYear W31148077302023 @default.
- W3114807730 crossrefType "journal-article" @default.
- W3114807730 hasAuthorship W3114807730A5014649653 @default.
- W3114807730 hasAuthorship W3114807730A5063060227 @default.
- W3114807730 hasBestOaLocation W31148077301 @default.
- W3114807730 hasConcept C126189478 @default.
- W3114807730 hasConcept C126322002 @default.
- W3114807730 hasConcept C150903083 @default.
- W3114807730 hasConcept C185592680 @default.
- W3114807730 hasConcept C207001950 @default.
- W3114807730 hasConcept C2777292910 @default.
- W3114807730 hasConcept C2779548794 @default.
- W3114807730 hasConcept C2779629538 @default.
- W3114807730 hasConcept C2780091579 @default.
- W3114807730 hasConcept C31903555 @default.
- W3114807730 hasConcept C43617362 @default.
- W3114807730 hasConcept C71924100 @default.
- W3114807730 hasConcept C86803240 @default.
- W3114807730 hasConcept C89423630 @default.
- W3114807730 hasConcept C98274493 @default.
- W3114807730 hasConceptScore W3114807730C126189478 @default.
- W3114807730 hasConceptScore W3114807730C126322002 @default.
- W3114807730 hasConceptScore W3114807730C150903083 @default.
- W3114807730 hasConceptScore W3114807730C185592680 @default.
- W3114807730 hasConceptScore W3114807730C207001950 @default.
- W3114807730 hasConceptScore W3114807730C2777292910 @default.
- W3114807730 hasConceptScore W3114807730C2779548794 @default.
- W3114807730 hasConceptScore W3114807730C2779629538 @default.
- W3114807730 hasConceptScore W3114807730C2780091579 @default.
- W3114807730 hasConceptScore W3114807730C31903555 @default.
- W3114807730 hasConceptScore W3114807730C43617362 @default.
- W3114807730 hasConceptScore W3114807730C71924100 @default.
- W3114807730 hasConceptScore W3114807730C86803240 @default.
- W3114807730 hasConceptScore W3114807730C89423630 @default.
- W3114807730 hasConceptScore W3114807730C98274493 @default.
- W3114807730 hasIssue "1" @default.
- W3114807730 hasLocation W31148077301 @default.
- W3114807730 hasLocation W31148077302 @default.
- W3114807730 hasLocation W31148077303 @default.
- W3114807730 hasOpenAccess W3114807730 @default.