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• W3114839372 abstract "Abstract Background: Cameroon remains a high malaria endemic country. The rapid emergence and spread of Plasmodium falciparum resistant parasites compelled the World Health Organisation (WHO) to recommend the change from monotherapies to artemisinin - based combination therapies (ACTs). This study aimed to assess the clinical efficacy and safety of artemisinin - based combination therapies in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon from 2004 to 2020. Methods: The preferred reporting items for systematic review and meta - analysis (PRISMA) statement were adopted for the selection of studies. The heterogeneity of the included studies was determined using Cochrane Q and the I 2 . The random effects model was used as standard to combine studies showing heterogeneity of Cochrane Q with P < 0.10 and I 2 > 50. Results: Out of the 4,920 articles and unpublished datasets screened, 16 records with a sample size of 3,737 participants on 8 generic ACTs fulfilled the inclusion criteria. The per protocol (PP) analysis pooled efficacy of the ACTs was 97.9 % (95 % CI, 97.2 - 98.7, P<0.01). Sub - group analyses were performed for ASAQ, AL and DHAP. The aggregated efficacies of ASAQ, AL and DHAP were 97.5 % (95 % CI, 96.3 - 98.8, P<0.01), 99.4 % (95 % CI, 98.6 - 100.0, P=0.39), 98.0 % (95 % CI, 96.3 - 99.7, P=0.28) respectively. The pooled efficacies were above the WHO minimum benchmark of 90.0%. The ACTs are well tolerated and common adverse events reported were asthenia, diarrhoea, abdominal pain, anorexia, nausea and vomiting, headache and dizziness. Conclusion: This study reported a high pooled efficacy for all ACTs. AL and DHAP were found to have higher cumulative efficacies than ASAQ. The ACTs are still efficacious and well tolerated for the treatment of malaria in Cameroon. However, there is need for continuous monitoring of efficacy of ACTs despite the high cure rates as resistance seems inevitable." @default.
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• W3114839372 date "2020-07-22" @default.
• W3114839372 modified "2023-09-25" @default.
• W3114839372 title "Clinical Efficacy and Safety of Artemisinin-based Combination Therapies in the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Cameroon: A Systematic Review and Meta-Analysis from Individual Patient Data (2004-2020)" @default.
• W3114839372 doi "https://doi.org/10.21203/rs.3.rs-45427/v1" @default.
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