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- W3114881515 abstract "Background and Aims: Olfactory impairment has been associated with increased mortality, mainly cardiovascular mortality and neurodegenerative diseases. Therefore, there is great interest in the measurement of olfactory capacity, to analyze its association with cardiovascular and cognitive phenotypes in several populations. However, measuring smell perception is a time-consuming task and the vast majority of existing cohorts are lacking this measure. Smell perception is genetically determined and some strong associations of specific odorant with single nucleotide polymorphisms (SNPs) in olfactory receptor genes (OR) have been reported. Therefore, our aim was to create a genomic biomarker consisting of a polygenic genetic risk score (GRS) including SNPs in OR as candidate genes." @default.
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- W3114881515 date "2020-12-01" @default.
- W3114881515 modified "2023-09-26" @default.
- W3114881515 title "Association between olfactory function and cognition in a high cardiovascular risk population: Construction of a polygenic risk score including olfactory receptor genes for mendelian randomization" @default.
- W3114881515 doi "https://doi.org/10.1016/j.atherosclerosis.2020.10.211" @default.
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