Matches in SemOpenAlex for { <https://semopenalex.org/work/W3114952116> ?p ?o ?g. }
- W3114952116 endingPage "24" @default.
- W3114952116 startingPage "24" @default.
- W3114952116 abstract "We studied the effect of human lactoferrin (hLf) on degenerative changes in the nigrostriatal system and associated behavioral deficits in the animal model of Parkinson disease. Nigrostriatal dopaminergic injury was induced by single administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 40 mg/kg) to five-month-old C57Bl/6 mice. Behavioral disturbances were assessed in the open field and rotarod tests and by the stride length analysis. Structural deficits were assessed by the counts of tyrosine hydroxylase (TH)-immunoreactive neurons in the substantia nigra and optical density (OD) of TH-immunolabeled fibers in the striatum. Acute MPTP treatment induced long-term behavioral deficit and degenerative changes in the nigrostriatal system. Pretreatment with hLf prevented body weight loss and promoted recovery of motor functions and exploratory behavior. Importantly, OD of TH-positive fibers in the striatum of mice treated with hLf almost returned to normal, and the number of TH-positive cells in the substantia nigra significantly increased on day 28. These results indicate that hLf produces a neuroprotective effect and probably stimulates neuroregeneration under conditions of MPTP toxicity in our model. A relationship between behavioral deficits and nigrostriatal system disturbances at delayed terms after MPTP administration was found." @default.
- W3114952116 created "2021-01-05" @default.
- W3114952116 creator A5000239857 @default.
- W3114952116 creator A5003970530 @default.
- W3114952116 creator A5022988380 @default.
- W3114952116 creator A5088501282 @default.
- W3114952116 date "2021-01-01" @default.
- W3114952116 modified "2023-10-01" @default.
- W3114952116 title "Pretreatment with Human Lactoferrin Had a Positive Effect on the Dynamics of Mouse Nigrostriatal System Recovery after Acute MPTP Exposure" @default.
- W3114952116 cites W1086543529 @default.
- W3114952116 cites W1510211954 @default.
- W3114952116 cites W1520955829 @default.
- W3114952116 cites W1586184394 @default.
- W3114952116 cites W1965735795 @default.
- W3114952116 cites W1967922486 @default.
- W3114952116 cites W1972359555 @default.
- W3114952116 cites W1979278926 @default.
- W3114952116 cites W1979755786 @default.
- W3114952116 cites W1985091985 @default.
- W3114952116 cites W1988441542 @default.
- W3114952116 cites W1999875121 @default.
- W3114952116 cites W2009740169 @default.
- W3114952116 cites W2018932383 @default.
- W3114952116 cites W2022911097 @default.
- W3114952116 cites W2027970428 @default.
- W3114952116 cites W2030472958 @default.
- W3114952116 cites W2030536065 @default.
- W3114952116 cites W2031852956 @default.
- W3114952116 cites W2038150636 @default.
- W3114952116 cites W2044726983 @default.
- W3114952116 cites W2047069320 @default.
- W3114952116 cites W2047465729 @default.
- W3114952116 cites W2050381823 @default.
- W3114952116 cites W2050610603 @default.
- W3114952116 cites W2054087453 @default.
- W3114952116 cites W2054333837 @default.
- W3114952116 cites W2065346279 @default.
- W3114952116 cites W2071584366 @default.
- W3114952116 cites W2074421138 @default.
- W3114952116 cites W2074482174 @default.
- W3114952116 cites W2074565049 @default.
- W3114952116 cites W2100876024 @default.
- W3114952116 cites W2114049362 @default.
- W3114952116 cites W2123913108 @default.
- W3114952116 cites W2139414585 @default.
- W3114952116 cites W2147352493 @default.
- W3114952116 cites W2150074066 @default.
- W3114952116 cites W2155414406 @default.
- W3114952116 cites W2167279371 @default.
- W3114952116 cites W2175835252 @default.
- W3114952116 cites W2211814408 @default.
- W3114952116 cites W2404459463 @default.
- W3114952116 cites W2570313025 @default.
- W3114952116 cites W2587017561 @default.
- W3114952116 cites W2742270752 @default.
- W3114952116 cites W2803828490 @default.
- W3114952116 cites W2804318423 @default.
- W3114952116 cites W2886151905 @default.
- W3114952116 cites W2906111512 @default.
- W3114952116 cites W2969463304 @default.
- W3114952116 cites W2972792856 @default.
- W3114952116 cites W2981712547 @default.
- W3114952116 cites W3015071931 @default.
- W3114952116 cites W3038523604 @default.
- W3114952116 cites W4211123396 @default.
- W3114952116 cites W62603772 @default.
- W3114952116 doi "https://doi.org/10.3390/biology10010024" @default.
- W3114952116 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7823682" @default.
- W3114952116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33401480" @default.
- W3114952116 hasPublicationYear "2021" @default.
- W3114952116 type Work @default.
- W3114952116 sameAs 3114952116 @default.
- W3114952116 citedByCount "12" @default.
- W3114952116 countsByYear W31149521162021 @default.
- W3114952116 countsByYear W31149521162022 @default.
- W3114952116 countsByYear W31149521162023 @default.
- W3114952116 crossrefType "journal-article" @default.
- W3114952116 hasAuthorship W3114952116A5000239857 @default.
- W3114952116 hasAuthorship W3114952116A5003970530 @default.
- W3114952116 hasAuthorship W3114952116A5022988380 @default.
- W3114952116 hasAuthorship W3114952116A5088501282 @default.
- W3114952116 hasBestOaLocation W31149521161 @default.
- W3114952116 hasConcept C126322002 @default.
- W3114952116 hasConcept C134018914 @default.
- W3114952116 hasConcept C137183658 @default.
- W3114952116 hasConcept C159167319 @default.
- W3114952116 hasConcept C169760540 @default.
- W3114952116 hasConcept C25498285 @default.
- W3114952116 hasConcept C2776355744 @default.
- W3114952116 hasConcept C2778674702 @default.
- W3114952116 hasConcept C2779134260 @default.
- W3114952116 hasConcept C2779734285 @default.
- W3114952116 hasConcept C2780062018 @default.
- W3114952116 hasConcept C2780358027 @default.
- W3114952116 hasConcept C2780938664 @default.
- W3114952116 hasConcept C513476851 @default.
- W3114952116 hasConcept C71924100 @default.
- W3114952116 hasConcept C86803240 @default.