Matches in SemOpenAlex for { <https://semopenalex.org/work/W3114996881> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3114996881 abstract "Background Susceptible individuals experience hypoxia-induced pulmonary hypertension when ascending to high altitude. Descent is considered the primary intervention to treat this condition. A human feasibility study testing influences of severe sustained normobaric hypoxia corresponding to >7,000 m altitude on the heart allowed us to follow the evolution of pulmonary hypertension using state-of-the-art cardiovascular imaging. Material & Methods Two healthy, professional mountaineers (subject A, male 57 years, subject B, female 50 years) first pre-acclimatized for one week in the field at 4559 m altitude. Then, they stayed at the :envihab facility of the German Aerospace Center in Cologne where normobaric hypoxia was achieved by nitrogen dilution starting at 13.5% O2 to a minimum of 8% O2 over three weeks. Afterwards, 8.5% O2 during the daytime and 8.8% O2 at night was kept for another 14 days. Velocity encoded single plane phase contrast MRI of the pulmonary artery (PA) and echocardiography were performed 1 month before, during and 1 and 3 months after hypoxia for assessment of right ventricular (RV) function, PA pressure, area, flow and distensibility. Results Systolic PA pressure (PAPsys) was closely related to the decrease in oxygen during acclimatization. In subject B PAPsys peaked at 67 mmHg, 48 mmHg higher than baseline. PAPsys decreased steadily to a minimum of 44 mmHg after two weeks while still at 8.55% oxygen. Peak values occurred with clinical symptoms of acute mountain sickness and a drop in exercise capacity but without signs of cerebral or pulmonary edema. In subject A peak PAPsys was 44 mmHg and remained stable over the entire hypoxia exposure. Conclusion In healthy humans, severe normobaric hypoxia induces pulmonary hypertension with paradoxically preserved right ventricular function. Pulmonary hypertension may improve over time in some individuals, even in the face of sustained hypoxia. The findings attest to the remarkable physiological reserve of healthy human beings allowing for adaptation to massively increased pulmonary pressure. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal." @default.
- W3114996881 created "2021-01-05" @default.
- W3114996881 creator A5000845703 @default.
- W3114996881 creator A5004550002 @default.
- W3114996881 creator A5007822263 @default.
- W3114996881 creator A5010942787 @default.
- W3114996881 creator A5017690840 @default.
- W3114996881 creator A5019736800 @default.
- W3114996881 creator A5022787593 @default.
- W3114996881 creator A5051095385 @default.
- W3114996881 creator A5053048440 @default.
- W3114996881 creator A5057990755 @default.
- W3114996881 creator A5065965358 @default.
- W3114996881 creator A5089388570 @default.
- W3114996881 date "2019-04-01" @default.
- W3114996881 modified "2023-10-01" @default.
- W3114996881 title "Evolution of Human Pulmonary Hemodynamics during Severe Sustained Hypoxia" @default.
- W3114996881 doi "https://doi.org/10.1096/fasebj.2019.33.1_supplement.531.5" @default.
- W3114996881 hasPublicationYear "2019" @default.
- W3114996881 type Work @default.
- W3114996881 sameAs 3114996881 @default.
- W3114996881 citedByCount "0" @default.
- W3114996881 crossrefType "journal-article" @default.
- W3114996881 hasAuthorship W3114996881A5000845703 @default.
- W3114996881 hasAuthorship W3114996881A5004550002 @default.
- W3114996881 hasAuthorship W3114996881A5007822263 @default.
- W3114996881 hasAuthorship W3114996881A5010942787 @default.
- W3114996881 hasAuthorship W3114996881A5017690840 @default.
- W3114996881 hasAuthorship W3114996881A5019736800 @default.
- W3114996881 hasAuthorship W3114996881A5022787593 @default.
- W3114996881 hasAuthorship W3114996881A5051095385 @default.
- W3114996881 hasAuthorship W3114996881A5053048440 @default.
- W3114996881 hasAuthorship W3114996881A5057990755 @default.
- W3114996881 hasAuthorship W3114996881A5065965358 @default.
- W3114996881 hasAuthorship W3114996881A5089388570 @default.
- W3114996881 hasConcept C105702510 @default.
- W3114996881 hasConcept C126322002 @default.
- W3114996881 hasConcept C164705383 @default.
- W3114996881 hasConcept C178790620 @default.
- W3114996881 hasConcept C185592680 @default.
- W3114996881 hasConcept C2780930700 @default.
- W3114996881 hasConcept C2780940725 @default.
- W3114996881 hasConcept C42219234 @default.
- W3114996881 hasConcept C540031477 @default.
- W3114996881 hasConcept C71924100 @default.
- W3114996881 hasConcept C7836513 @default.
- W3114996881 hasConcept C8240015 @default.
- W3114996881 hasConcept C84393581 @default.
- W3114996881 hasConceptScore W3114996881C105702510 @default.
- W3114996881 hasConceptScore W3114996881C126322002 @default.
- W3114996881 hasConceptScore W3114996881C164705383 @default.
- W3114996881 hasConceptScore W3114996881C178790620 @default.
- W3114996881 hasConceptScore W3114996881C185592680 @default.
- W3114996881 hasConceptScore W3114996881C2780930700 @default.
- W3114996881 hasConceptScore W3114996881C2780940725 @default.
- W3114996881 hasConceptScore W3114996881C42219234 @default.
- W3114996881 hasConceptScore W3114996881C540031477 @default.
- W3114996881 hasConceptScore W3114996881C71924100 @default.
- W3114996881 hasConceptScore W3114996881C7836513 @default.
- W3114996881 hasConceptScore W3114996881C8240015 @default.
- W3114996881 hasConceptScore W3114996881C84393581 @default.
- W3114996881 hasIssue "S1" @default.
- W3114996881 hasLocation W31149968811 @default.
- W3114996881 hasOpenAccess W3114996881 @default.
- W3114996881 hasPrimaryLocation W31149968811 @default.
- W3114996881 hasRelatedWork W1981687682 @default.
- W3114996881 hasRelatedWork W2055715636 @default.
- W3114996881 hasRelatedWork W2104932000 @default.
- W3114996881 hasRelatedWork W2355487988 @default.
- W3114996881 hasRelatedWork W2362051303 @default.
- W3114996881 hasRelatedWork W2382696197 @default.
- W3114996881 hasRelatedWork W2401161077 @default.
- W3114996881 hasRelatedWork W2736287222 @default.
- W3114996881 hasRelatedWork W2762219442 @default.
- W3114996881 hasRelatedWork W3107283639 @default.
- W3114996881 hasVolume "33" @default.
- W3114996881 isParatext "false" @default.
- W3114996881 isRetracted "false" @default.
- W3114996881 magId "3114996881" @default.
- W3114996881 workType "article" @default.