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- W3114996910 endingPage "351" @default.
- W3114996910 startingPage "351" @default.
- W3114996910 abstract "Glioblastoma is the most common malignant primary brain tumor in adults and is almost invariably fatal. Despite our growing understanding of the various mechanisms underlying treatment failure, the standard-of-care therapy has not changed over the last two decades, signifying a great unmet need. The challenges of treating glioblastoma are many and include inadequate drug or agent delivery across the blood–brain barrier, abundant intra- and intertumoral heterogeneity, redundant signaling pathways, and an immunosuppressive microenvironment. Here, we review the innate and adaptive molecular mechanisms underlying glioblastoma’s treatment resistance, emphasizing the intrinsic challenges therapeutic interventions must overcome—namely, the blood–brain barrier, tumoral heterogeneity, and microenvironment—and the mechanisms of resistance to conventional treatments, targeted therapy, and immunotherapy." @default.
- W3114996910 created "2021-01-05" @default.
- W3114996910 creator A5006268625 @default.
- W3114996910 creator A5071489703 @default.
- W3114996910 creator A5084333703 @default.
- W3114996910 date "2020-12-31" @default.
- W3114996910 modified "2023-10-17" @default.
- W3114996910 title "Molecular Mechanisms of Treatment Resistance in Glioblastoma" @default.
- W3114996910 cites W128151115 @default.
- W3114996910 cites W1585754595 @default.
- W3114996910 cites W1706016362 @default.
- W3114996910 cites W1808226550 @default.
- W3114996910 cites W1824539338 @default.
- W3114996910 cites W1891618255 @default.
- W3114996910 cites W1893358364 @default.
- W3114996910 cites W1911973956 @default.
- W3114996910 cites W1933912253 @default.
- W3114996910 cites W1941304965 @default.
- W3114996910 cites W1948215485 @default.
- W3114996910 cites W1959444207 @default.
- W3114996910 cites W1965462445 @default.
- W3114996910 cites W1969795656 @default.
- W3114996910 cites W1976112178 @default.
- W3114996910 cites W1980485314 @default.
- W3114996910 cites W1982509114 @default.
- W3114996910 cites W1986352745 @default.
- W3114996910 cites W1987834338 @default.
- W3114996910 cites W1992301683 @default.
- W3114996910 cites W1994130246 @default.
- W3114996910 cites W1999920903 @default.
- W3114996910 cites W2001544973 @default.
- W3114996910 cites W2001717792 @default.
- W3114996910 cites W2002266833 @default.
- W3114996910 cites W2008550171 @default.
- W3114996910 cites W2013517841 @default.
- W3114996910 cites W2017230319 @default.
- W3114996910 cites W2025183726 @default.
- W3114996910 cites W2025372894 @default.
- W3114996910 cites W2026480865 @default.
- W3114996910 cites W2030017878 @default.
- W3114996910 cites W2040458067 @default.
- W3114996910 cites W2040683695 @default.
- W3114996910 cites W2040878803 @default.
- W3114996910 cites W2045796964 @default.
- W3114996910 cites W2047697327 @default.
- W3114996910 cites W2049553585 @default.
- W3114996910 cites W2055573510 @default.
- W3114996910 cites W2059971436 @default.
- W3114996910 cites W2060551076 @default.
- W3114996910 cites W2070968699 @default.
- W3114996910 cites W2073606915 @default.
- W3114996910 cites W2077524564 @default.
- W3114996910 cites W2078510083 @default.
- W3114996910 cites W2079179944 @default.
- W3114996910 cites W2089482729 @default.
- W3114996910 cites W2091511345 @default.
- W3114996910 cites W2091828932 @default.
- W3114996910 cites W2094144162 @default.
- W3114996910 cites W2095999479 @default.
- W3114996910 cites W2096287682 @default.
- W3114996910 cites W2099064703 @default.
- W3114996910 cites W2100567246 @default.
- W3114996910 cites W2100901335 @default.
- W3114996910 cites W2102614717 @default.
- W3114996910 cites W2105100844 @default.
- W3114996910 cites W2105528101 @default.
- W3114996910 cites W2106675906 @default.
- W3114996910 cites W2109816625 @default.
- W3114996910 cites W2111424734 @default.
- W3114996910 cites W2114140047 @default.
- W3114996910 cites W2114701172 @default.
- W3114996910 cites W2114824375 @default.
- W3114996910 cites W2116583846 @default.
- W3114996910 cites W2116844416 @default.
- W3114996910 cites W2117581777 @default.
- W3114996910 cites W2118731052 @default.
- W3114996910 cites W2122445377 @default.
- W3114996910 cites W2123040085 @default.
- W3114996910 cites W2123273088 @default.
- W3114996910 cites W2123610802 @default.
- W3114996910 cites W2124736921 @default.
- W3114996910 cites W2125411036 @default.
- W3114996910 cites W2125493895 @default.
- W3114996910 cites W2125521995 @default.
- W3114996910 cites W2128035403 @default.
- W3114996910 cites W2128546510 @default.
- W3114996910 cites W2129418270 @default.
- W3114996910 cites W2129921538 @default.
- W3114996910 cites W2147968481 @default.
- W3114996910 cites W2151264866 @default.
- W3114996910 cites W2152387543 @default.
- W3114996910 cites W2154313451 @default.
- W3114996910 cites W2155957543 @default.
- W3114996910 cites W2156330848 @default.
- W3114996910 cites W2156353875 @default.
- W3114996910 cites W2157005154 @default.
- W3114996910 cites W2158751879 @default.
- W3114996910 cites W2160834915 @default.