Matches in SemOpenAlex for { <https://semopenalex.org/work/W3115060092> ?p ?o ?g. }
- W3115060092 endingPage "144" @default.
- W3115060092 startingPage "133" @default.
- W3115060092 abstract "• Transplantation of DPSCs improved motor skills and muscle activity in rat brain lesion . • Transplantation of DPSCs prevented the atrophy of the striatum. • Transplantation of DPSCs impeded gliosis and microgliosis in rats. • Transplantation of DPSC downregulated Caspase-3 in brain lesion. • Transplantation of DPSCs decreased the expression of inflammatory cytokines, TNF and IL-1β, at mRNA level. Stem cell-based therapy has recently offered a promising alternative for the remedy of neurodegenerative disorders like Huntington's disease (HD). Herein, we investigated the potential ameliorative effects of implantation of dental pulp stem cells (DPSCs) in 3-nitropropionic acid (3-NP) rat models of HD. In this regard, human DPSCs were isolated, culture-expanded and implanted in rats lesioned with 3-NP. Post-transplantation examinations revealed that DPSCs were able to survive and augment motor skills and muscle activity. Histological analysis showed DPSCs treatment hampered the shrinkage of the striatum along with the inhibition of gliosis and microgliosis in the striatum of 3-NP rat models. We also detected the downregulation of Caspase-3 and pro-inflammatory cytokines such as TNF and IL-1β upon DPSCs grafting. Overall, these findings imply that the grafting of DPSCs could repair motor-skill impairment and induce neurogenesis, probably through the secretion of neurotrophic factors and the modulation of neuroinflammatory response in HD animal models." @default.
- W3115060092 created "2021-01-05" @default.
- W3115060092 creator A5014040588 @default.
- W3115060092 creator A5017674365 @default.
- W3115060092 creator A5023224274 @default.
- W3115060092 creator A5030045562 @default.
- W3115060092 creator A5042304352 @default.
- W3115060092 creator A5043258881 @default.
- W3115060092 creator A5043274150 @default.
- W3115060092 creator A5054909624 @default.
- W3115060092 creator A5065686837 @default.
- W3115060092 creator A5074645389 @default.
- W3115060092 date "2021-09-01" @default.
- W3115060092 modified "2023-09-27" @default.
- W3115060092 title "Transplantation of human dental pulp stem cells compensates for striatal atrophy and modulates neuro-inflammation in 3-nitropropionic acid rat model of Huntington’s disease" @default.
- W3115060092 cites W1485794983 @default.
- W3115060092 cites W1585630836 @default.
- W3115060092 cites W1966952941 @default.
- W3115060092 cites W1969483326 @default.
- W3115060092 cites W1973502470 @default.
- W3115060092 cites W1973642029 @default.
- W3115060092 cites W1980658715 @default.
- W3115060092 cites W1984014420 @default.
- W3115060092 cites W1993299404 @default.
- W3115060092 cites W1994476469 @default.
- W3115060092 cites W1994567019 @default.
- W3115060092 cites W2001856136 @default.
- W3115060092 cites W2005710138 @default.
- W3115060092 cites W2007439129 @default.
- W3115060092 cites W2017796669 @default.
- W3115060092 cites W2018345924 @default.
- W3115060092 cites W2023341576 @default.
- W3115060092 cites W2024390877 @default.
- W3115060092 cites W2026888593 @default.
- W3115060092 cites W2032454607 @default.
- W3115060092 cites W2032744846 @default.
- W3115060092 cites W2033195771 @default.
- W3115060092 cites W2033420039 @default.
- W3115060092 cites W2035176325 @default.
- W3115060092 cites W2035976926 @default.
- W3115060092 cites W2038696332 @default.
- W3115060092 cites W2039237464 @default.
- W3115060092 cites W2045586545 @default.
- W3115060092 cites W2045641591 @default.
- W3115060092 cites W2046931991 @default.
- W3115060092 cites W2048802800 @default.
- W3115060092 cites W2049387807 @default.
- W3115060092 cites W2058327425 @default.
- W3115060092 cites W2061151435 @default.
- W3115060092 cites W2061904165 @default.
- W3115060092 cites W2071923304 @default.
- W3115060092 cites W2073197774 @default.
- W3115060092 cites W2074410961 @default.
- W3115060092 cites W2074624875 @default.
- W3115060092 cites W2077676713 @default.
- W3115060092 cites W2088390244 @default.
- W3115060092 cites W2094689616 @default.
- W3115060092 cites W2097542229 @default.
- W3115060092 cites W2097556137 @default.
- W3115060092 cites W2101326888 @default.
- W3115060092 cites W2116864112 @default.
- W3115060092 cites W2121998108 @default.
- W3115060092 cites W2129511674 @default.
- W3115060092 cites W2136767600 @default.
- W3115060092 cites W2137414549 @default.
- W3115060092 cites W2143243890 @default.
- W3115060092 cites W2145040826 @default.
- W3115060092 cites W2146056177 @default.
- W3115060092 cites W2154452702 @default.
- W3115060092 cites W2161026119 @default.
- W3115060092 cites W2167752818 @default.
- W3115060092 cites W2169125140 @default.
- W3115060092 cites W2180157788 @default.
- W3115060092 cites W2321162021 @default.
- W3115060092 cites W2482137989 @default.
- W3115060092 cites W2528486741 @default.
- W3115060092 cites W2609509800 @default.
- W3115060092 cites W2738204278 @default.
- W3115060092 cites W2738822321 @default.
- W3115060092 cites W2770504624 @default.
- W3115060092 cites W2793018077 @default.
- W3115060092 cites W2800849719 @default.
- W3115060092 cites W2909854286 @default.
- W3115060092 cites W2916732515 @default.
- W3115060092 cites W2942046430 @default.
- W3115060092 cites W3030991768 @default.
- W3115060092 cites W4211110682 @default.
- W3115060092 cites W4293247451 @default.
- W3115060092 cites W4323236995 @default.
- W3115060092 doi "https://doi.org/10.1016/j.neures.2020.12.002" @default.
- W3115060092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33359180" @default.
- W3115060092 hasPublicationYear "2021" @default.
- W3115060092 type Work @default.
- W3115060092 sameAs 3115060092 @default.
- W3115060092 citedByCount "14" @default.
- W3115060092 countsByYear W31150600922021 @default.
- W3115060092 countsByYear W31150600922022 @default.
- W3115060092 countsByYear W31150600922023 @default.