Matches in SemOpenAlex for { <https://semopenalex.org/work/W3115134920> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W3115134920 abstract "Abstract Background Introns have been shown to be spliced in a defined order, and this order influences both alternative splicing regulation and splicing fidelity, but previous studies have only considered neighbouring introns. The detailed intron splicing order remains unknown. Results In this work, I developed a method that can calculate the intron splicing orders of all introns in each transcript. A simulation study showed that this method can accurately calculate intron splicing orders. I further applied this method to real pombe, fruit fly, zebrafish and human sequencing datasets and found that intron splicing orders change from gene to gene and that humans contain more not in-order spliced transcripts than S. pombe, fruit fly and zebrafish. In addition, I reconfirmed that the first introns in humans are spliced slower than those in S. pombe, fruit fly and zebrafish genome-widely. Both the calculated most likely orders and the method developed here are available on the web. Conclusions I developed a novel computational method to calculate the intron splicing orders and applied the method to real sequencing datasets. I obtained intron splicing orders for hundreds or thousands of genes in four organisms. I found humans contain more number of not in-order spliced transcripts. Keywords : Splicing; Intron splicing order; Most likely order; Bayesian network" @default.
- W3115134920 created "2021-01-05" @default.
- W3115134920 creator A5087592842 @default.
- W3115134920 date "2020-03-19" @default.
- W3115134920 modified "2023-09-26" @default.
- W3115134920 title "Calculating the Most Likely Intron Splicing Orders in S. pombe, Fruit Fly, Zebrafish, and Humans" @default.
- W3115134920 doi "https://doi.org/10.21203/rs.3.rs-17940/v1" @default.
- W3115134920 hasPublicationYear "2020" @default.
- W3115134920 type Work @default.
- W3115134920 sameAs 3115134920 @default.
- W3115134920 citedByCount "0" @default.
- W3115134920 crossrefType "posted-content" @default.
- W3115134920 hasAuthorship W3115134920A5087592842 @default.
- W3115134920 hasBestOaLocation W31151349201 @default.
- W3115134920 hasConcept C104317684 @default.
- W3115134920 hasConcept C118346598 @default.
- W3115134920 hasConcept C2776878037 @default.
- W3115134920 hasConcept C36823959 @default.
- W3115134920 hasConcept C54355233 @default.
- W3115134920 hasConcept C54458228 @default.
- W3115134920 hasConcept C64962909 @default.
- W3115134920 hasConcept C67705224 @default.
- W3115134920 hasConcept C70721500 @default.
- W3115134920 hasConcept C73758832 @default.
- W3115134920 hasConcept C86803240 @default.
- W3115134920 hasConcept C94671646 @default.
- W3115134920 hasConceptScore W3115134920C104317684 @default.
- W3115134920 hasConceptScore W3115134920C118346598 @default.
- W3115134920 hasConceptScore W3115134920C2776878037 @default.
- W3115134920 hasConceptScore W3115134920C36823959 @default.
- W3115134920 hasConceptScore W3115134920C54355233 @default.
- W3115134920 hasConceptScore W3115134920C54458228 @default.
- W3115134920 hasConceptScore W3115134920C64962909 @default.
- W3115134920 hasConceptScore W3115134920C67705224 @default.
- W3115134920 hasConceptScore W3115134920C70721500 @default.
- W3115134920 hasConceptScore W3115134920C73758832 @default.
- W3115134920 hasConceptScore W3115134920C86803240 @default.
- W3115134920 hasConceptScore W3115134920C94671646 @default.
- W3115134920 hasLocation W31151349201 @default.
- W3115134920 hasLocation W31151349202 @default.
- W3115134920 hasOpenAccess W3115134920 @default.
- W3115134920 hasPrimaryLocation W31151349201 @default.
- W3115134920 hasRelatedWork W12360627 @default.
- W3115134920 hasRelatedWork W12486300 @default.
- W3115134920 hasRelatedWork W14893489 @default.
- W3115134920 hasRelatedWork W19255035 @default.
- W3115134920 hasRelatedWork W25586608 @default.
- W3115134920 hasRelatedWork W33055493 @default.
- W3115134920 hasRelatedWork W3419827 @default.
- W3115134920 hasRelatedWork W4839031 @default.
- W3115134920 hasRelatedWork W6896571 @default.
- W3115134920 hasRelatedWork W7669837 @default.
- W3115134920 isParatext "false" @default.
- W3115134920 isRetracted "false" @default.
- W3115134920 magId "3115134920" @default.
- W3115134920 workType "article" @default.