Matches in SemOpenAlex for { <https://semopenalex.org/work/W3115136688> ?p ?o ?g. }
- W3115136688 endingPage "37" @default.
- W3115136688 startingPage "37" @default.
- W3115136688 abstract "For years, it has been reported that Alzheimer’s disease (AD) is the most common cause of dementia. Various external and internal factors may contribute to the early onset of AD. This review highlights a contribution of the disturbances in the microbiota–gut–brain (MGB) axis to the development of AD. Alteration in the gut microbiota composition is determined by increase in the permeability of the gut barrier and immune cell activation, leading to impairment in the blood–brain barrier function that promotes neuroinflammation, neuronal loss, neural injury, and ultimately AD. Numerous studies have shown that the gut microbiota plays a crucial role in brain function and changes in the behavior of individuals and the formation of bacterial amyloids. Lipopolysaccharides and bacterial amyloids synthesized by the gut microbiota can trigger the immune cells residing in the brain and can activate the immune response leading to neuroinflammation. Growing experimental and clinical data indicate the prominent role of gut dysbiosis and microbiota–host interactions in AD. Modulation of the gut microbiota with antibiotics or probiotic supplementation may create new preventive and therapeutic options in AD. Accumulating evidences affirm that research on MGB involvement in AD is necessary for new treatment targets and therapies for AD." @default.
- W3115136688 created "2021-01-05" @default.
- W3115136688 creator A5010555932 @default.
- W3115136688 creator A5018160495 @default.
- W3115136688 creator A5031465014 @default.
- W3115136688 creator A5061837677 @default.
- W3115136688 date "2020-12-24" @default.
- W3115136688 modified "2023-10-09" @default.
- W3115136688 title "The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?" @default.
- W3115136688 cites W123195486 @default.
- W3115136688 cites W1420654867 @default.
- W3115136688 cites W1512201595 @default.
- W3115136688 cites W1515023627 @default.
- W3115136688 cites W1526611045 @default.
- W3115136688 cites W1566600743 @default.
- W3115136688 cites W157594748 @default.
- W3115136688 cites W1579016001 @default.
- W3115136688 cites W1614579334 @default.
- W3115136688 cites W1759131233 @default.
- W3115136688 cites W1824975628 @default.
- W3115136688 cites W1841389452 @default.
- W3115136688 cites W1862417723 @default.
- W3115136688 cites W1892636863 @default.
- W3115136688 cites W1897859562 @default.
- W3115136688 cites W1969905245 @default.
- W3115136688 cites W1974115860 @default.
- W3115136688 cites W1978832792 @default.
- W3115136688 cites W1979216870 @default.
- W3115136688 cites W1979495039 @default.
- W3115136688 cites W1981801578 @default.
- W3115136688 cites W1982313782 @default.
- W3115136688 cites W1984283611 @default.
- W3115136688 cites W1985060701 @default.
- W3115136688 cites W1987717478 @default.
- W3115136688 cites W1988130273 @default.
- W3115136688 cites W1988506400 @default.
- W3115136688 cites W1991278461 @default.
- W3115136688 cites W1991780813 @default.
- W3115136688 cites W1993237799 @default.
- W3115136688 cites W1995250682 @default.
- W3115136688 cites W1998585277 @default.
- W3115136688 cites W1998726234 @default.
- W3115136688 cites W2000424893 @default.
- W3115136688 cites W2001615085 @default.
- W3115136688 cites W2002714430 @default.
- W3115136688 cites W2004668790 @default.
- W3115136688 cites W2011336591 @default.
- W3115136688 cites W2012543776 @default.
- W3115136688 cites W2014684858 @default.
- W3115136688 cites W2017431945 @default.
- W3115136688 cites W2018708829 @default.
- W3115136688 cites W2021133027 @default.
- W3115136688 cites W2027685112 @default.
- W3115136688 cites W2027691251 @default.
- W3115136688 cites W2033492638 @default.
- W3115136688 cites W2035475961 @default.
- W3115136688 cites W2036993607 @default.
- W3115136688 cites W2040581856 @default.
- W3115136688 cites W2044090829 @default.
- W3115136688 cites W2045918539 @default.
- W3115136688 cites W2052554412 @default.
- W3115136688 cites W2066382988 @default.
- W3115136688 cites W2068731812 @default.
- W3115136688 cites W2070448139 @default.
- W3115136688 cites W2071534876 @default.
- W3115136688 cites W2073366531 @default.
- W3115136688 cites W2077553363 @default.
- W3115136688 cites W2078166953 @default.
- W3115136688 cites W2078253056 @default.
- W3115136688 cites W2080841042 @default.
- W3115136688 cites W2081164888 @default.
- W3115136688 cites W2082281485 @default.
- W3115136688 cites W2082321986 @default.
- W3115136688 cites W2083054399 @default.
- W3115136688 cites W2085926435 @default.
- W3115136688 cites W2088170171 @default.
- W3115136688 cites W2096891797 @default.
- W3115136688 cites W2099514643 @default.
- W3115136688 cites W2099594801 @default.
- W3115136688 cites W2110011317 @default.
- W3115136688 cites W2111335747 @default.
- W3115136688 cites W2114102190 @default.
- W3115136688 cites W2119511745 @default.
- W3115136688 cites W2121079175 @default.
- W3115136688 cites W2123473800 @default.
- W3115136688 cites W2124072274 @default.
- W3115136688 cites W2124667416 @default.
- W3115136688 cites W2128492849 @default.
- W3115136688 cites W2129133439 @default.
- W3115136688 cites W2134141380 @default.
- W3115136688 cites W2135025386 @default.
- W3115136688 cites W2135957529 @default.
- W3115136688 cites W2142143326 @default.
- W3115136688 cites W2149399096 @default.
- W3115136688 cites W2149538964 @default.
- W3115136688 cites W2152252699 @default.
- W3115136688 cites W2154264360 @default.
- W3115136688 cites W2155058651 @default.