FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3115162871> ?p ?o ?g. }

• W3115162871 abstract "Abstract Background The malaria vaccine, RTS,S/AS01, demonstrated an enhanced efficacy (86.7%) in a delayed third fractional dose (0.1.7Fx) regimen in controlled human malaria infection trials compared with a standard full-dose (0.1.2) regimen (62.5%). To understand the humoral component of the RTS,S/AS01 vaccine-induced protection against sporozoite infection in these 2 regimens, we investigated the serum antibody dynamics of 0.1.2 and 0.1.7Fx groups vaccinees. Methods The specific binding responses (magnitude) and dissociation rates (avidity) of serum antibodies interaction with a recombinant Plasmodium falciparum circumsporozoite protein (CSP) and peptides corresponding to the central repeat region (NANP6), the C-terminal region (PF16), and the N-terminal junction (N-interface) of CSP, respectively, were measured using a Biolayer Interferometry assay. Results On the day of challenge, higher NANP6-specific antibody responses were associated with protection in the 0.1.2 group. In contrast, slower antibody dissociation rates for CSP and PF16 binding were observed in the protected 0.1.7Fx group. Protected vaccinees of both groups exhibited 2- to 3-fold higher N-interface peptide binding antibody responses. Conclusions Unlike the standard dose, the delayed-fractional third dose of RTS,S/AS01 induced higher avidity CSP and PF16 binding antibodies that were associated with protection against sporozoite infection." @default.
• W3115162871 created "2021-01-05" @default.
• W3115162871 creator A5008165819 @default.
• W3115162871 creator A5011882174 @default.
• W3115162871 creator A5020898531 @default.
• W3115162871 creator A5027270152 @default.
• W3115162871 creator A5029750402 @default.
• W3115162871 creator A5034536696 @default.
• W3115162871 creator A5040104802 @default.
• W3115162871 creator A5066583780 @default.
• W3115162871 creator A5091007685 @default.
• W3115162871 date "2020-12-30" @default.
• W3115162871 modified "2023-10-16" @default.
• W3115162871 title "Magnitude, Specificity, and Avidity of Sporozoite-Specific Antibodies Associate With Protection Status and Distinguish Among RTS,S/AS01 Dose Regimens" @default.
• W3115162871 cites W1817614869 @default.
• W3115162871 cites W1988731714 @default.
• W3115162871 cites W2036887760 @default.
• W3115162871 cites W2042126545 @default.
• W3115162871 cites W2049580315 @default.
• W3115162871 cites W2054577865 @default.
• W3115162871 cites W2108476551 @default.
• W3115162871 cites W2158202876 @default.
• W3115162871 cites W2163861382 @default.
• W3115162871 cites W2164153211 @default.
• W3115162871 cites W2167823105 @default.
• W3115162871 cites W2171789634 @default.
• W3115162871 cites W2244674613 @default.
• W3115162871 cites W2414241210 @default.
• W3115162871 cites W2436449558 @default.
• W3115162871 cites W2744836284 @default.
• W3115162871 cites W2769957615 @default.
• W3115162871 cites W2791741332 @default.
• W3115162871 cites W2793636839 @default.
• W3115162871 cites W2884623540 @default.
• W3115162871 cites W2897261190 @default.
• W3115162871 cites W2914283863 @default.
• W3115162871 cites W2946248791 @default.
• W3115162871 cites W4210717618 @default.
• W3115162871 cites W4236532324 @default.
• W3115162871 cites W4237230653 @default.
• W3115162871 cites W4254848468 @default.
• W3115162871 cites W65828984 @default.
• W3115162871 cites W798958370 @default.
• W3115162871 doi "https://doi.org/10.1093/ofid/ofaa644" @default.
• W3115162871 hasPublicationYear "2020" @default.
• W3115162871 type Work @default.
• W3115162871 sameAs 3115162871 @default.
• W3115162871 citedByCount "6" @default.
• W3115162871 countsByYear W31151628712021 @default.
• W3115162871 countsByYear W31151628712022 @default.
• W3115162871 countsByYear W31151628712023 @default.
• W3115162871 crossrefType "journal-article" @default.
• W3115162871 hasAuthorship W3115162871A5008165819 @default.
• W3115162871 hasAuthorship W3115162871A5011882174 @default.
• W3115162871 hasAuthorship W3115162871A5020898531 @default.
• W3115162871 hasAuthorship W3115162871A5027270152 @default.
• W3115162871 hasAuthorship W3115162871A5029750402 @default.
• W3115162871 hasAuthorship W3115162871A5034536696 @default.
• W3115162871 hasAuthorship W3115162871A5040104802 @default.
• W3115162871 hasAuthorship W3115162871A5066583780 @default.
• W3115162871 hasAuthorship W3115162871A5091007685 @default.
• W3115162871 hasBestOaLocation W31151628711 @default.
• W3115162871 hasConcept C126322002 @default.
• W3115162871 hasConcept C147483822 @default.
• W3115162871 hasConcept C159047783 @default.
• W3115162871 hasConcept C159654299 @default.
• W3115162871 hasConcept C179223381 @default.
• W3115162871 hasConcept C203014093 @default.
• W3115162871 hasConcept C2778048844 @default.
• W3115162871 hasConcept C2778371730 @default.
• W3115162871 hasConcept C2781034427 @default.
• W3115162871 hasConcept C2781074509 @default.
• W3115162871 hasConcept C2781413609 @default.
• W3115162871 hasConcept C71924100 @default.
• W3115162871 hasConceptScore W3115162871C126322002 @default.
• W3115162871 hasConceptScore W3115162871C147483822 @default.
• W3115162871 hasConceptScore W3115162871C159047783 @default.
• W3115162871 hasConceptScore W3115162871C159654299 @default.
• W3115162871 hasConceptScore W3115162871C179223381 @default.
• W3115162871 hasConceptScore W3115162871C203014093 @default.
• W3115162871 hasConceptScore W3115162871C2778048844 @default.
• W3115162871 hasConceptScore W3115162871C2778371730 @default.
• W3115162871 hasConceptScore W3115162871C2781034427 @default.
• W3115162871 hasConceptScore W3115162871C2781074509 @default.
• W3115162871 hasConceptScore W3115162871C2781413609 @default.
• W3115162871 hasConceptScore W3115162871C71924100 @default.
• W3115162871 hasFunder F4320306137 @default.
• W3115162871 hasIssue "2" @default.
• W3115162871 hasLocation W31151628711 @default.
• W3115162871 hasOpenAccess W3115162871 @default.
• W3115162871 hasPrimaryLocation W31151628711 @default.
• W3115162871 hasRelatedWork W2104152050 @default.
• W3115162871 hasRelatedWork W2138147357 @default.
• W3115162871 hasRelatedWork W2256378346 @default.
• W3115162871 hasRelatedWork W2396343693 @default.
• W3115162871 hasRelatedWork W2570581564 @default.
• W3115162871 hasRelatedWork W2596065050 @default.
• W3115162871 hasRelatedWork W2974773766 @default.
• W3115162871 hasRelatedWork W3118646668 @default.
• W3115162871 hasRelatedWork W3137348162 @default.

• next