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• W3115181621 endingPage "105675" @default.
• W3115181621 startingPage "105675" @default.
• W3115181621 abstract "One in 113-178 females worldwide carry a premutation allele on the FMR1 gene. The FMR1 premutation is linked to neurocognitive and neuromotor impairments, although the phenotype is not fully understood, particularly with respect to age effects. This study sought to define oculomotor response inhibition skills in women with the FMR1 premutation and their association with age and fall risk. We employed an antisaccade eye-tracking paradigm to index oculomotor inhibition skills in 35 women with the FMR1 premutation and 28 control women. The FMR1 premutation group exhibited longer antisaccade latency and reduced accuracy relative to controls, indicating deficient response inhibition skills. Longer response latency was associated with older age in the FMR1 premutation and was also predictive of fall risk. Findings highlight the utility of the antisaccade paradigm for detecting early signs of age-related executive decline in the FMR1 premutation, which is related to fall risk. Findings support the need for clinical prevention efforts to decrease and delay the trajectory of age-related executive decline in women with the FMR1 premutation during midlife." @default.
• W3115181621 created "2021-01-05" @default.
• W3115181621 creator A5008713375 @default.
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• W3115181621 date "2021-03-01" @default.
• W3115181621 modified "2023-09-30" @default.
• W3115181621 title "Response Inhibition Deficits in Women with the FMR1 Premutation are Associated with Age and Fall Risk" @default.
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• W3115181621 doi "https://doi.org/10.1016/j.bandc.2020.105675" @default.
• W3115181621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7945960" @default.
• W3115181621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33387817" @default.
• W3115181621 hasPublicationYear "2021" @default.
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