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- W3115183905 abstract "Background: Coronavirus disease 2019 (COVID-19) has affected millions of people, and several chronic medical conditions appeared to increase the risk of severe COVID-19 However, limited data are available about the outcomes of COVID-19 in patients with chronic kidney disease (CKD) Methods: This was an observational study of patients with CKD at three affiliated hospitals in New York City who were diagnosed with COVID-19 by reverse-transcriptase polymerase chain reaction of nasopharyngeal swab specimens collected in the emergency departments between March 3rd and April 21st, 2020 We stratified patients into three groups: pre-dialysis CKD, dialysis, and transplant Data are shown as median (interquartile range) Logistic regression was used to identify CKD characteristics associated with nonsurvival Results: Of the 372 confirmed COVID-19 patients with CKD, 182 were pre-dialysis, 149 were on dialysis, and 41 had functional kidney transplant The median age of the pre-dialysis group was 75 (63-85) years, dialysis group 66 (58-74) years, and transplant group 63 (48-71) years Men comprised 62 4% of the cohort Baseline serum creatinine was 1 5 (1 2-2 2) mg/dL in the pre-dialysis group By the end of the observation period, 78 5% of patients were discharged or had died Of these patients, mortality was highest in the pre-dialysis group (26 9%), followed by dialysis (24 2%), then transplant (9 8%) groups Almost half of the cohort was receiving ACE-inhibitors or ARBs pre-COVID-19, which was not associated with non-survival In the pre-dialysis group, baseline serum phosphorus was associated with non-survival (OR 1 5 per each 1 0 mg/dL of increase in serum phosphorus) Anemia, defined as hemoglobin <10 g/dL, was also associated with non-survival (OR 3 1) in that group Body mass index (BMI)<25 kg/m2 was paradoxically associated with non-survival (OR 2 7) in patients with pre-dialysis CKD Conclusions: Our data demonstrate that mortality in this cohort, particularly in patients with pre-dialysis CKD, was substantially higher than in the general population in New York City Poorly controlled CKD complications, including CKD-mineral and bone disorder and anemia, as well as low BMI were associated with mortality Ongoing control of CKD complications may serve as an opportunity to improve outcomes of COVID-19 in patients with CKD" @default.
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- W3115183905 date "2020-01-01" @default.
- W3115183905 modified "2023-09-27" @default.
- W3115183905 title "COVID-19 in patients with CKD in New York City" @default.
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