Matches in SemOpenAlex for { <https://semopenalex.org/work/W3115220659> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W3115220659 endingPage "1083" @default.
- W3115220659 startingPage "1076" @default.
- W3115220659 abstract "Background: Tranexamic acid (TXA) is an antifibrinolytic used for prophylaxis and treatment of acute bleeding. Although fixed dosing is often used in practice, weight-based dosing is sometimes used in the operating room (OR). The efficacy and safety of fixed-dose TXA is not well established in patients with above average weight or body mass index. Objective: To characterize the efficacy and safety of intravenous TXA in obese patients with major bleeding. Methods: This was a retrospective review of 165 patients receiving fixed-dose TXA for acute bleeding outside the OR. Blood product administration (BPA) before and after TXA was collected, along with demographic and bleed-related information. Thrombotic events were the major safety end point. A prespecified subgroup analysis was conducted in patients weighing at least 100 kg compared with a lower weight. Logistic regression was performed to determine whether an association exists between body weight and blood product requirement after TXA administration. Results: In the 24 hours after TXA, patients received an average of 4.17 units of blood product. Patients weighing at least 100 kg averaged 4.04 total units, compared with 4.19 units in the lower weight group ( P = 0.603). Administration of individual blood products did not differ between groups, and thrombotic events were similar. Regression analysis did not associate weight with total BPA. Conclusion and Relevance: In patients receiving fixed-dose TXA, weight does not appear to alter blood product requirements or rates of adverse thrombotic events. These data support continued use of fixed-dose TXA for treatment of acute major bleeding in obese patients." @default.
- W3115220659 created "2021-01-05" @default.
- W3115220659 creator A5014987999 @default.
- W3115220659 creator A5015160769 @default.
- W3115220659 creator A5088661513 @default.
- W3115220659 creator A5090769525 @default.
- W3115220659 date "2020-12-31" @default.
- W3115220659 modified "2023-09-26" @default.
- W3115220659 title "Impact of Obesity on Tranexamic Acid Efficacy in Adult Patients With Major Bleeding" @default.
- W3115220659 cites W1967300023 @default.
- W3115220659 cites W1980390900 @default.
- W3115220659 cites W1983199628 @default.
- W3115220659 cites W2011827851 @default.
- W3115220659 cites W2036468563 @default.
- W3115220659 cites W2058587587 @default.
- W3115220659 cites W2107339086 @default.
- W3115220659 cites W2111548427 @default.
- W3115220659 cites W2124649734 @default.
- W3115220659 cites W2129887916 @default.
- W3115220659 cites W2156125313 @default.
- W3115220659 cites W2161369674 @default.
- W3115220659 cites W2162249417 @default.
- W3115220659 cites W2321905524 @default.
- W3115220659 cites W2324437595 @default.
- W3115220659 cites W2361301902 @default.
- W3115220659 cites W2607870311 @default.
- W3115220659 cites W2791409209 @default.
- W3115220659 cites W2823911872 @default.
- W3115220659 cites W2924764747 @default.
- W3115220659 cites W2944789449 @default.
- W3115220659 cites W3036528941 @default.
- W3115220659 cites W3082496343 @default.
- W3115220659 cites W3084265249 @default.
- W3115220659 cites W4211043869 @default.
- W3115220659 doi "https://doi.org/10.1177/1060028020983323" @default.
- W3115220659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33384016" @default.
- W3115220659 hasPublicationYear "2020" @default.
- W3115220659 type Work @default.
- W3115220659 sameAs 3115220659 @default.
- W3115220659 citedByCount "2" @default.
- W3115220659 countsByYear W31152206592022 @default.
- W3115220659 crossrefType "journal-article" @default.
- W3115220659 hasAuthorship W3115220659A5014987999 @default.
- W3115220659 hasAuthorship W3115220659A5015160769 @default.
- W3115220659 hasAuthorship W3115220659A5088661513 @default.
- W3115220659 hasAuthorship W3115220659A5090769525 @default.
- W3115220659 hasConcept C126322002 @default.
- W3115220659 hasConcept C141071460 @default.
- W3115220659 hasConcept C197934379 @default.
- W3115220659 hasConcept C2776623344 @default.
- W3115220659 hasConcept C2777288759 @default.
- W3115220659 hasConcept C2777396833 @default.
- W3115220659 hasConcept C2779637338 @default.
- W3115220659 hasConcept C2780221984 @default.
- W3115220659 hasConcept C2781436528 @default.
- W3115220659 hasConcept C2991743468 @default.
- W3115220659 hasConcept C42219234 @default.
- W3115220659 hasConcept C71924100 @default.
- W3115220659 hasConceptScore W3115220659C126322002 @default.
- W3115220659 hasConceptScore W3115220659C141071460 @default.
- W3115220659 hasConceptScore W3115220659C197934379 @default.
- W3115220659 hasConceptScore W3115220659C2776623344 @default.
- W3115220659 hasConceptScore W3115220659C2777288759 @default.
- W3115220659 hasConceptScore W3115220659C2777396833 @default.
- W3115220659 hasConceptScore W3115220659C2779637338 @default.
- W3115220659 hasConceptScore W3115220659C2780221984 @default.
- W3115220659 hasConceptScore W3115220659C2781436528 @default.
- W3115220659 hasConceptScore W3115220659C2991743468 @default.
- W3115220659 hasConceptScore W3115220659C42219234 @default.
- W3115220659 hasConceptScore W3115220659C71924100 @default.
- W3115220659 hasIssue "9" @default.
- W3115220659 hasLocation W31152206591 @default.
- W3115220659 hasOpenAccess W3115220659 @default.
- W3115220659 hasPrimaryLocation W31152206591 @default.
- W3115220659 hasRelatedWork W1966027379 @default.
- W3115220659 hasRelatedWork W1968549988 @default.
- W3115220659 hasRelatedWork W2022689571 @default.
- W3115220659 hasRelatedWork W2100887247 @default.
- W3115220659 hasRelatedWork W2115702839 @default.
- W3115220659 hasRelatedWork W2183694321 @default.
- W3115220659 hasRelatedWork W2588587747 @default.
- W3115220659 hasRelatedWork W2754863463 @default.
- W3115220659 hasRelatedWork W3115220659 @default.
- W3115220659 hasRelatedWork W3130794088 @default.
- W3115220659 hasVolume "55" @default.
- W3115220659 isParatext "false" @default.
- W3115220659 isRetracted "false" @default.
- W3115220659 magId "3115220659" @default.
- W3115220659 workType "article" @default.