FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3115222004> ?p ?o ?g. }

• W3115222004 endingPage "10559" @default.
• W3115222004 startingPage "10547" @default.
• W3115222004 abstract "Targeted multidrug-loaded delivery systems have emerged as an advanced strategy for cancer treatment. In this context, antibodies, hormones, and small peptides have been coupled to the surface of drug carriers, such as liposomes, polymeric and metallic nanoparticles loaded with drugs, as tumor-specific ligands. In the present study, we have grafted a natural macrophage stimulating peptide, tuftsin, on the surface of the liposomes (LPs) that were loaded with doxorubicin (DOX) and/or curcumin (CUR), by attaching to its C-terminus a palmitoyl residue (Thr-Lys-Pro-Arg-CO-NH-(CH2)2-NH-COC15H31, P.Tuft) to enable its grafting within the liposome's bilayer.The prepared drug-loaded liposomes (DOX LPs, CUR LPs, DOX-CUR LPs, P.Tuft-LPs, P.Tuft-DOX LPs, P.Tuft-CUR LPs, P.Tuft-DOX-CUR LPs) were thoroughly characterised in terms of particle size, drug content, encapsulation efficiency and structural properties using UV-visible spectroscopy, dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FTIR). The anti-cancer activity and drug toxicity of the liposomal formulations were examined on Ehrlich ascites carcinoma (EAC) tumor-induced mice model.A significant reduction in the tumor weight and volume was observed upon treating the tumor-bearing mice with palmitoyl tuftsin-grafted dual drug-loaded liposomes (P.Tuft-DOX-CUR LPs), as compared to the single drug/peptide-loaded formulation (DOX LPs, CUR LPs, DOX-CUR LPs, P.Tuft- LPs, P.Tuft-DOX LPs, P.Tuft-CUR LPs). Western blot analysis revealed that the tumor inhibition was associated with p53-mediated apoptotic pathway. Further, the biochemical and histological analysis revealed that the various liposomal preparation used in this study were non-toxic to the animals at the specified dose (10mg/kg).In conclusion, we have developed a targeted liposomal formulation of P.Tuftsin-bearing liposomes co-encapsulated with effective anti-cancer drugs such as doxorubicin and curcumin. In experimental animals, tumor inhibition by P.Tuft-DOX-CUR LPs indicates the synergistic therapeutic effect of the peptide and the dual drug." @default.
• W3115222004 created "2021-01-05" @default.
• W3115222004 creator A5015141287 @default.
• W3115222004 creator A5026577312 @default.
• W3115222004 creator A5041581025 @default.
• W3115222004 creator A5056093785 @default.
• W3115222004 creator A5087750266 @default.
• W3115222004 date "2020-12-01" @default.
• W3115222004 modified "2023-10-13" @default.
• W3115222004 title "Tuftsin-Bearing Liposomes Co-Encapsulated with Doxorubicin and Curcumin Efficiently Inhibit EAC Tumor Growth in Mice" @default.
• W3115222004 cites W1562582348 @default.
• W3115222004 cites W1588791780 @default.
• W3115222004 cites W1966813948 @default.
• W3115222004 cites W1969402650 @default.
• W3115222004 cites W1975867653 @default.
• W3115222004 cites W1977647279 @default.
• W3115222004 cites W1978581079 @default.
• W3115222004 cites W1981072770 @default.
• W3115222004 cites W1985659903 @default.
• W3115222004 cites W1989493570 @default.
• W3115222004 cites W1998241565 @default.
• W3115222004 cites W2005082473 @default.
• W3115222004 cites W2005475049 @default.
• W3115222004 cites W2013533833 @default.
• W3115222004 cites W2014427634 @default.
• W3115222004 cites W2015753524 @default.
• W3115222004 cites W2056149397 @default.
• W3115222004 cites W2061181552 @default.
• W3115222004 cites W2077241706 @default.
• W3115222004 cites W2087266891 @default.
• W3115222004 cites W2104398672 @default.
• W3115222004 cites W2105014485 @default.
• W3115222004 cites W2107599029 @default.
• W3115222004 cites W2114288422 @default.
• W3115222004 cites W2125462130 @default.
• W3115222004 cites W2144284013 @default.
• W3115222004 cites W2157428889 @default.
• W3115222004 cites W2161756544 @default.
• W3115222004 cites W2187976253 @default.
• W3115222004 cites W2256666377 @default.
• W3115222004 cites W2343859046 @default.
• W3115222004 cites W2399196594 @default.
• W3115222004 cites W2415528931 @default.
• W3115222004 cites W2736956081 @default.
• W3115222004 cites W2792308604 @default.
• W3115222004 cites W2960083904 @default.
• W3115222004 cites W2964321870 @default.
• W3115222004 cites W2984278982 @default.
• W3115222004 cites W3007148383 @default.
• W3115222004 cites W4248975835 @default.
• W3115222004 doi "https://doi.org/10.2147/ijn.s276336" @default.
• W3115222004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7783201" @default.
• W3115222004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33414637" @default.
• W3115222004 hasPublicationYear "2020" @default.
• W3115222004 type Work @default.
• W3115222004 sameAs 3115222004 @default.
• W3115222004 citedByCount "10" @default.
• W3115222004 countsByYear W31152220042022 @default.
• W3115222004 countsByYear W31152220042023 @default.
• W3115222004 crossrefType "journal-article" @default.
• W3115222004 hasAuthorship W3115222004A5015141287 @default.
• W3115222004 hasAuthorship W3115222004A5026577312 @default.
• W3115222004 hasAuthorship W3115222004A5041581025 @default.
• W3115222004 hasAuthorship W3115222004A5056093785 @default.
• W3115222004 hasAuthorship W3115222004A5087750266 @default.
• W3115222004 hasBestOaLocation W31152220041 @default.
• W3115222004 hasConcept C141071460 @default.
• W3115222004 hasConcept C185154212 @default.
• W3115222004 hasConcept C185592680 @default.
• W3115222004 hasConcept C2776694085 @default.
• W3115222004 hasConcept C2778250585 @default.
• W3115222004 hasConcept C2778905913 @default.
• W3115222004 hasConcept C2779281246 @default.
• W3115222004 hasConcept C2781303535 @default.
• W3115222004 hasConcept C55493867 @default.
• W3115222004 hasConcept C71924100 @default.
• W3115222004 hasConcept C98274493 @default.
• W3115222004 hasConceptScore W3115222004C141071460 @default.
• W3115222004 hasConceptScore W3115222004C185154212 @default.
• W3115222004 hasConceptScore W3115222004C185592680 @default.
• W3115222004 hasConceptScore W3115222004C2776694085 @default.
• W3115222004 hasConceptScore W3115222004C2778250585 @default.
• W3115222004 hasConceptScore W3115222004C2778905913 @default.
• W3115222004 hasConceptScore W3115222004C2779281246 @default.
• W3115222004 hasConceptScore W3115222004C2781303535 @default.
• W3115222004 hasConceptScore W3115222004C55493867 @default.
• W3115222004 hasConceptScore W3115222004C71924100 @default.
• W3115222004 hasConceptScore W3115222004C98274493 @default.
• W3115222004 hasLocation W31152220041 @default.
• W3115222004 hasLocation W31152220042 @default.
• W3115222004 hasLocation W31152220043 @default.
• W3115222004 hasLocation W31152220044 @default.
• W3115222004 hasOpenAccess W3115222004 @default.
• W3115222004 hasPrimaryLocation W31152220041 @default.
• W3115222004 hasRelatedWork W1964161255 @default.
• W3115222004 hasRelatedWork W1970648358 @default.
• W3115222004 hasRelatedWork W1999803973 @default.
• W3115222004 hasRelatedWork W2058897077 @default.

• next