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• W3115258312 abstract "Abstract The apical junction of epithelial cells can generate force to control cell geometry and perform contractile processes while maintaining barrier function and adhesion. Yet, the structural basis for force generation at the apical junction is not fully understood. Here, we describe 2 synaptopodin-dependent actomyosin structures that are spatially, temporally, and structurally distinct. The first structure is formed by retrograde flow of synaptopodin initiated at the apical junction, creating sarcomeric stress fibers that lie parallel to the junction and insert into junctional complexes on the apical plane. Retrograde flow of synaptopodin is also seen at vinculin-decorated basal junctions on the basal plane. Contractions of apical stress fibers is associated with clustering of membrane complexes via side-on synaptopodin linkers whereas contractions of stress fibers inserted at the apical junction via head-on synaptopodin linkers results in junction shortening. Upon junction maturation, apical stress fibers are disassembled. In mature epithelial monolayer, a motorized “contractomere” complex capable of “walking the junction” is formed at junction vertices. Contractomere motility results in changes in junctional length, altering the overall shape of the cell and packing geometry within the monolayer. We propose a model of epithelial homeostasis that utilizes contractomere motility to preserve the permeability barrier during intercellular movement and junctional processes. Summary Statement Synaptopodin retrograde flows initiate the assembly of apical and basal stress fibers from the apical and basal junctions. In mature apical junction, a motorized junctional complex, we termed the contractomere, allows the apical junction to change length and organize cell geometry within a confluent monolayer." @default.
• W3115258312 created "2021-01-05" @default.
• W3115258312 creator A5007174526 @default.
• W3115258312 creator A5053300476 @default.
• W3115258312 creator A5069546508 @default.
• W3115258312 creator A5085397028 @default.
• W3115258312 creator A5090882872 @default.
• W3115258312 date "2021-01-01" @default.
• W3115258312 modified "2023-09-26" @default.
• W3115258312 title "Synaptopodin is required for stress fiber and contractomere assembly at the epithelial junction" @default.
• W3115258312 cites W118105748 @default.
• W3115258312 cites W1250575375 @default.
• W3115258312 cites W1486172246 @default.
• W3115258312 cites W1575833044 @default.
• W3115258312 cites W1600063873 @default.
• W3115258312 cites W1775787469 @default.
• W3115258312 cites W1859152884 @default.
• W3115258312 cites W1966779855 @default.
• W3115258312 cites W1975720258 @default.
• W3115258312 cites W1978082911 @default.
• W3115258312 cites W1986047072 @default.
• W3115258312 cites W1990258395 @default.
• W3115258312 cites W1997087774 @default.
• W3115258312 cites W1999143977 @default.
• W3115258312 cites W2000333351 @default.
• W3115258312 cites W2000684972 @default.
• W3115258312 cites W2006829024 @default.
• W3115258312 cites W2007660746 @default.
• W3115258312 cites W2010274527 @default.
• W3115258312 cites W2011231091 @default.
• W3115258312 cites W2012034410 @default.
• W3115258312 cites W2016727199 @default.
• W3115258312 cites W2017372730 @default.
• W3115258312 cites W2020984081 @default.
• W3115258312 cites W2027085747 @default.
• W3115258312 cites W2029232466 @default.
• W3115258312 cites W2029436667 @default.
• W3115258312 cites W2030029307 @default.
• W3115258312 cites W2033897003 @default.
• W3115258312 cites W2034341872 @default.
• W3115258312 cites W2040376369 @default.
• W3115258312 cites W2041966019 @default.
• W3115258312 cites W2050612706 @default.
• W3115258312 cites W2055343292 @default.
• W3115258312 cites W2056563854 @default.
• W3115258312 cites W2059999294 @default.
• W3115258312 cites W2060545109 @default.
• W3115258312 cites W2063227306 @default.
• W3115258312 cites W2069684013 @default.
• W3115258312 cites W2071156256 @default.
• W3115258312 cites W2072106617 @default.
• W3115258312 cites W2073006837 @default.
• W3115258312 cites W2075533337 @default.
• W3115258312 cites W2083095583 @default.
• W3115258312 cites W2084640600 @default.
• W3115258312 cites W2084961029 @default.
• W3115258312 cites W2085500046 @default.
• W3115258312 cites W2086985378 @default.
• W3115258312 cites W2088265369 @default.
• W3115258312 cites W2088903728 @default.
• W3115258312 cites W2089505716 @default.
• W3115258312 cites W2094441795 @default.
• W3115258312 cites W2101281572 @default.
• W3115258312 cites W2102701307 @default.
• W3115258312 cites W2103677757 @default.
• W3115258312 cites W2105402224 @default.
• W3115258312 cites W2107154293 @default.
• W3115258312 cites W2108725006 @default.
• W3115258312 cites W2110436896 @default.
• W3115258312 cites W2118013290 @default.
• W3115258312 cites W2119658007 @default.
• W3115258312 cites W2125029933 @default.
• W3115258312 cites W2127213821 @default.
• W3115258312 cites W2127695266 @default.
• W3115258312 cites W2128625225 @default.
• W3115258312 cites W2130837149 @default.
• W3115258312 cites W2133691034 @default.
• W3115258312 cites W2135300306 @default.
• W3115258312 cites W2136053788 @default.
• W3115258312 cites W2138347793 @default.
• W3115258312 cites W2139671059 @default.
• W3115258312 cites W2139731224 @default.
• W3115258312 cites W2140669673 @default.
• W3115258312 cites W2144537799 @default.
• W3115258312 cites W2146696453 @default.
• W3115258312 cites W2163423429 @default.
• W3115258312 cites W2165385004 @default.
• W3115258312 cites W2167709294 @default.
• W3115258312 cites W2170733892 @default.
• W3115258312 cites W2178450581 @default.
• W3115258312 cites W2191883975 @default.
• W3115258312 cites W2529523284 @default.
• W3115258312 cites W2530473422 @default.
• W3115258312 cites W2624404902 @default.
• W3115258312 cites W2736304951 @default.
• W3115258312 cites W2745088195 @default.
• W3115258312 cites W2752859080 @default.
• W3115258312 cites W2758509781 @default.
• W3115258312 cites W2765316714 @default.
• W3115258312 cites W2765942116 @default.

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