Matches in SemOpenAlex for { <https://semopenalex.org/work/W3115273068> ?p ?o ?g. }
- W3115273068 endingPage "347" @default.
- W3115273068 startingPage "347" @default.
- W3115273068 abstract "During the development of mouse embryonic stem cells (ESC) to neuronal committed cells (NCC), coordinated changes in the expression of 2851 genes take place, mediated by the nuclear form of FGFR1. In this paper, widespread differences are demonstrated in the ESC and NCC inter- and intra-chromosomal interactions, chromatin looping, the formation of CTCF- and nFGFR1-linked Topologically Associating Domains (TADs) on a genome-wide scale and in exemplary HoxA-D loci. The analysis centered on HoxA cluster shows that blocking FGFR1 disrupts the loop formation. FGFR1 binding and genome locales are predictive of the genome interactions; likewise, chromatin interactions along with nFGFR1 binding are predictive of the genome function and correlate with genome regulatory attributes and gene expression. This study advances a topologically integrated genome archipelago model that undergoes structural transformations through the formation of nFGFR1-associated TADs. The makeover of the TAD islands serves to recruit distinct ontogenic programs during the development of the ESC to NCC." @default.
- W3115273068 created "2021-01-05" @default.
- W3115273068 creator A5025862478 @default.
- W3115273068 creator A5031515832 @default.
- W3115273068 creator A5032753064 @default.
- W3115273068 creator A5034503776 @default.
- W3115273068 creator A5035612918 @default.
- W3115273068 creator A5040205891 @default.
- W3115273068 creator A5048193191 @default.
- W3115273068 creator A5067055460 @default.
- W3115273068 date "2020-12-31" @default.
- W3115273068 modified "2023-10-15" @default.
- W3115273068 title "Global Genome Conformational Programming during Neuronal Development Is Associated with CTCF and Nuclear FGFR1—The Genome Archipelago Model" @default.
- W3115273068 cites W1492867725 @default.
- W3115273068 cites W1528537419 @default.
- W3115273068 cites W1608481794 @default.
- W3115273068 cites W1815472980 @default.
- W3115273068 cites W1831401007 @default.
- W3115273068 cites W1869362176 @default.
- W3115273068 cites W1964478384 @default.
- W3115273068 cites W1965863160 @default.
- W3115273068 cites W1967734956 @default.
- W3115273068 cites W1968002146 @default.
- W3115273068 cites W1973062929 @default.
- W3115273068 cites W1980751171 @default.
- W3115273068 cites W1984340155 @default.
- W3115273068 cites W1986230815 @default.
- W3115273068 cites W1986974894 @default.
- W3115273068 cites W2036306750 @default.
- W3115273068 cites W2048002474 @default.
- W3115273068 cites W2069736702 @default.
- W3115273068 cites W2070021921 @default.
- W3115273068 cites W2073026107 @default.
- W3115273068 cites W2073354279 @default.
- W3115273068 cites W2087624913 @default.
- W3115273068 cites W2091521382 @default.
- W3115273068 cites W2096950509 @default.
- W3115273068 cites W2100305481 @default.
- W3115273068 cites W2104691647 @default.
- W3115273068 cites W2106968589 @default.
- W3115273068 cites W2107574245 @default.
- W3115273068 cites W2116622696 @default.
- W3115273068 cites W2131478115 @default.
- W3115273068 cites W2157576490 @default.
- W3115273068 cites W2158804744 @default.
- W3115273068 cites W2159675211 @default.
- W3115273068 cites W2163112976 @default.
- W3115273068 cites W2165996867 @default.
- W3115273068 cites W2172400873 @default.
- W3115273068 cites W2180089959 @default.
- W3115273068 cites W2185693210 @default.
- W3115273068 cites W2228154033 @default.
- W3115273068 cites W2243544746 @default.
- W3115273068 cites W2308890438 @default.
- W3115273068 cites W2330808969 @default.
- W3115273068 cites W2493763501 @default.
- W3115273068 cites W2510930684 @default.
- W3115273068 cites W2523285811 @default.
- W3115273068 cites W2572596504 @default.
- W3115273068 cites W2604200375 @default.
- W3115273068 cites W2734870846 @default.
- W3115273068 cites W2735035409 @default.
- W3115273068 cites W2741790413 @default.
- W3115273068 cites W2761133874 @default.
- W3115273068 cites W2765567136 @default.
- W3115273068 cites W2766284392 @default.
- W3115273068 cites W2769649226 @default.
- W3115273068 cites W2775505403 @default.
- W3115273068 cites W2789833802 @default.
- W3115273068 cites W2888425844 @default.
- W3115273068 cites W2890279677 @default.
- W3115273068 cites W2906676329 @default.
- W3115273068 cites W2950340687 @default.
- W3115273068 cites W2951322997 @default.
- W3115273068 cites W2952014756 @default.
- W3115273068 cites W2952203741 @default.
- W3115273068 cites W2952584337 @default.
- W3115273068 cites W3003909932 @default.
- W3115273068 cites W3017323102 @default.
- W3115273068 doi "https://doi.org/10.3390/ijms22010347" @default.
- W3115273068 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7795191" @default.
- W3115273068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33396256" @default.
- W3115273068 hasPublicationYear "2020" @default.
- W3115273068 type Work @default.
- W3115273068 sameAs 3115273068 @default.
- W3115273068 citedByCount "8" @default.
- W3115273068 countsByYear W31152730682021 @default.
- W3115273068 countsByYear W31152730682022 @default.
- W3115273068 countsByYear W31152730682023 @default.
- W3115273068 crossrefType "journal-article" @default.
- W3115273068 hasAuthorship W3115273068A5025862478 @default.
- W3115273068 hasAuthorship W3115273068A5031515832 @default.
- W3115273068 hasAuthorship W3115273068A5032753064 @default.
- W3115273068 hasAuthorship W3115273068A5034503776 @default.
- W3115273068 hasAuthorship W3115273068A5035612918 @default.
- W3115273068 hasAuthorship W3115273068A5040205891 @default.
- W3115273068 hasAuthorship W3115273068A5048193191 @default.
- W3115273068 hasAuthorship W3115273068A5067055460 @default.