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- W3115299320 endingPage "718" @default.
- W3115299320 startingPage "709" @default.
- W3115299320 abstract "Introduction: Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular calcium (Ca2+) release channels located on the endoplasmic/sarcoplasmic reticulum. The availability of the structure of the ligand-binding domain of IP3Rs has enabled the design of compatible ligands, but the limiting step remains their actual effectiveness in a biological context.Areas covered: This article summarizes the compelling literature on both agonists and antagonists targeting IP3Rs, emphasizing their strengths and limitations. The main challenges toward the discovery and development of IP3 receptor modulators are also described.Expert opinion: Despite significant progress in recent years, the pharmacology of IP3R still has major drawbacks, especially concerning the availability of specific antag onists. Moreover, drugs specifically targeting the three different subtypes of IP3R are especially needed." @default.
- W3115299320 created "2021-01-05" @default.
- W3115299320 creator A5001184848 @default.
- W3115299320 creator A5015296039 @default.
- W3115299320 creator A5019034390 @default.
- W3115299320 creator A5044892454 @default.
- W3115299320 creator A5058321520 @default.
- W3115299320 creator A5067158748 @default.
- W3115299320 date "2021-01-06" @default.
- W3115299320 modified "2023-09-27" @default.
- W3115299320 title "The discovery and development of IP3 receptor modulators: an update" @default.
- W3115299320 cites W122074300 @default.
- W3115299320 cites W1494420910 @default.
- W3115299320 cites W1503698015 @default.
- W3115299320 cites W1526274619 @default.
- W3115299320 cites W1539592459 @default.
- W3115299320 cites W1597778600 @default.
- W3115299320 cites W1644915246 @default.
- W3115299320 cites W1834569838 @default.
- W3115299320 cites W185167048 @default.
- W3115299320 cites W1897031304 @default.
- W3115299320 cites W1911507008 @default.
- W3115299320 cites W1946644148 @default.
- W3115299320 cites W1963901903 @default.
- W3115299320 cites W1972545408 @default.
- W3115299320 cites W1974802525 @default.
- W3115299320 cites W1976134600 @default.
- W3115299320 cites W1982417491 @default.
- W3115299320 cites W1982631458 @default.
- W3115299320 cites W1986903954 @default.
- W3115299320 cites W1987276980 @default.
- W3115299320 cites W1987342177 @default.
- W3115299320 cites W1994277245 @default.
- W3115299320 cites W2000597330 @default.
- W3115299320 cites W2001907971 @default.
- W3115299320 cites W2002287591 @default.
- W3115299320 cites W2002785473 @default.
- W3115299320 cites W2006703412 @default.
- W3115299320 cites W2008875238 @default.
- W3115299320 cites W2014985826 @default.
- W3115299320 cites W2017284616 @default.
- W3115299320 cites W2020828897 @default.
- W3115299320 cites W2024197810 @default.
- W3115299320 cites W2027094257 @default.
- W3115299320 cites W2028268498 @default.
- W3115299320 cites W2032292804 @default.
- W3115299320 cites W2032770343 @default.
- W3115299320 cites W2040541044 @default.
- W3115299320 cites W2042474871 @default.
- W3115299320 cites W2052601735 @default.
- W3115299320 cites W2058409310 @default.
- W3115299320 cites W2061198146 @default.
- W3115299320 cites W2066819563 @default.
- W3115299320 cites W2068823479 @default.
- W3115299320 cites W2077355636 @default.
- W3115299320 cites W2084077773 @default.
- W3115299320 cites W2085253273 @default.
- W3115299320 cites W2085757712 @default.
- W3115299320 cites W2088501605 @default.
- W3115299320 cites W2089913300 @default.
- W3115299320 cites W2092109656 @default.
- W3115299320 cites W2095236791 @default.
- W3115299320 cites W2096042945 @default.
- W3115299320 cites W2100688704 @default.
- W3115299320 cites W2106607865 @default.
- W3115299320 cites W2108411628 @default.
- W3115299320 cites W2117226055 @default.
- W3115299320 cites W2122947137 @default.
- W3115299320 cites W2123111841 @default.
- W3115299320 cites W2140012341 @default.
- W3115299320 cites W2145301606 @default.
- W3115299320 cites W2152573097 @default.
- W3115299320 cites W2159469824 @default.
- W3115299320 cites W2161435194 @default.
- W3115299320 cites W2162060020 @default.
- W3115299320 cites W2167511923 @default.
- W3115299320 cites W2169212669 @default.
- W3115299320 cites W2173669563 @default.
- W3115299320 cites W2230882011 @default.
- W3115299320 cites W2316200185 @default.
- W3115299320 cites W2318162270 @default.
- W3115299320 cites W2344605681 @default.
- W3115299320 cites W2517161479 @default.
- W3115299320 cites W2560253180 @default.
- W3115299320 cites W2566175288 @default.
- W3115299320 cites W2595978963 @default.
- W3115299320 cites W2597971795 @default.
- W3115299320 cites W2606631998 @default.
- W3115299320 cites W2755477791 @default.
- W3115299320 cites W2792738008 @default.
- W3115299320 cites W2795281866 @default.
- W3115299320 cites W2884580815 @default.
- W3115299320 cites W2904802473 @default.
- W3115299320 cites W2940716202 @default.
- W3115299320 cites W2951778995 @default.
- W3115299320 cites W2969731445 @default.
- W3115299320 cites W2989271671 @default.
- W3115299320 cites W2991598318 @default.