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• W3115300859 endingPage "e1040" @default.
• W3115300859 startingPage "e1022" @default.
• W3115300859 abstract "Low-grade chronic inflammation is commonly seen in polycystic ovary syndrome (PCOS) patients with elevated levels of inflammatory cytokines in the endometrium.This work aimed to increase the limited understanding of the mechanisms underlying cytokine synthesis and increased endometrial inflammation in PCOS patients.Endometrial biopsy samples were collected from non-PCOS (n = 17) and PCOS (n = 22) patients either during the proliferative phase of the menstrual cycle or with hyperplasia. Endometrial explants were prepared from PCOS patients and underwent pharmacological manipulation in vitro. The expression and localization of toll-like receptor 2 (TLR2)/4, key elements of innate immune signal transduction and nuclear factor κB (NFκB) signaling pathways, and multiple cytokines were comprehensively evaluated by Western blotting, immunohistochemistry, and immunofluorescence in endometrial tissues.We demonstrated the distribution of protein expression and localization associated with the significantly increased androgen receptor, TLR2, and TLR4-mediated activation of interferon regulatory factor-7 (IRF-7) and NFκB signaling, cytokine production, and endometrial inflammation in PCOS patients compared to non-PCOS patients with and without endometrial hyperplasia. In vitro experiments showed that 5-dihydrotestosterone (DHT) enhanced androgen receptor, TLR4, IRF-7, and p-NFκB p65 protein expression along with increased interferon α (IFNα) and IFNɣ abundance. The effects of DHT on IRF-7, p-NFκB p65, and IFN abundance were abolished by flutamide, an antiandrogen. Although 17β-estradiol (E2) decreased p-IRF-7 expression with little effect on TLR-mediated IRF7 and NFκB signaling or on cytokine protein levels, exposure to metformin alone or in combination with E2 suppressed interleukin-1 receptor-associated kinase 4 (IRAK4), p-IRF-7, IRF-7, IκB kinase α (IKKα), p-NFκB p65, IFNɣ, and tumor necrosis factor α protein expression.Cytokine synthesis and increased endometrial inflammation in PCOS patients are coupled to androgen-induced TLR4/IRF-7/NFκB signaling, which is inhibited by metformin treatment." @default.
• W3115300859 created "2021-01-05" @default.
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• W3115300859 date "2020-12-31" @default.
• W3115300859 modified "2023-10-16" @default.
• W3115300859 title "TLR4-Associated IRF-7 and NFκB Signaling Act as a Molecular Link Between Androgen and Metformin Activities and Cytokine Synthesis in the PCOS Endometrium" @default.
• W3115300859 cites W1230128795 @default.
• W3115300859 cites W1533963550 @default.
• W3115300859 cites W1577097214 @default.
• W3115300859 cites W1970586482 @default.
• W3115300859 cites W1971509596 @default.
• W3115300859 cites W1973239749 @default.
• W3115300859 cites W1973768574 @default.
• W3115300859 cites W1975861918 @default.
• W3115300859 cites W1980498769 @default.
• W3115300859 cites W1987353062 @default.
• W3115300859 cites W1989352504 @default.
• W3115300859 cites W1995586746 @default.
• W3115300859 cites W2013885669 @default.
• W3115300859 cites W2032002836 @default.
• W3115300859 cites W2033659078 @default.
• W3115300859 cites W2034831207 @default.
• W3115300859 cites W2042851093 @default.
• W3115300859 cites W2049088903 @default.
• W3115300859 cites W2053672725 @default.
• W3115300859 cites W2063485400 @default.
• W3115300859 cites W2071849150 @default.
• W3115300859 cites W2075846272 @default.
• W3115300859 cites W2100076759 @default.
• W3115300859 cites W2114781862 @default.
• W3115300859 cites W2119975890 @default.
• W3115300859 cites W2127904815 @default.
• W3115300859 cites W2130974208 @default.
• W3115300859 cites W2133883611 @default.
• W3115300859 cites W2134887638 @default.
• W3115300859 cites W2134907909 @default.
• W3115300859 cites W2140455334 @default.
• W3115300859 cites W2141861181 @default.
• W3115300859 cites W2142241097 @default.
• W3115300859 cites W2154248317 @default.
• W3115300859 cites W2164410268 @default.
• W3115300859 cites W2167164284 @default.
• W3115300859 cites W2204640292 @default.
• W3115300859 cites W2215478699 @default.
• W3115300859 cites W2313601588 @default.
• W3115300859 cites W2334361330 @default.
• W3115300859 cites W2346727301 @default.
• W3115300859 cites W2398526138 @default.
• W3115300859 cites W2411074315 @default.
• W3115300859 cites W2483090461 @default.
• W3115300859 cites W2489748506 @default.
• W3115300859 cites W2517294940 @default.
• W3115300859 cites W2518536270 @default.
• W3115300859 cites W2528009933 @default.
• W3115300859 cites W2531633185 @default.
• W3115300859 cites W2532706858 @default.
• W3115300859 cites W2554844456 @default.
• W3115300859 cites W2596227632 @default.
• W3115300859 cites W2625430513 @default.
• W3115300859 cites W2745171202 @default.
• W3115300859 cites W2778760154 @default.
• W3115300859 cites W2801400869 @default.
• W3115300859 cites W2889289499 @default.
• W3115300859 cites W2898032428 @default.
• W3115300859 cites W2903708727 @default.
• W3115300859 cites W2922715248 @default.
• W3115300859 cites W2929025230 @default.
• W3115300859 cites W2952709854 @default.
• W3115300859 cites W2953550393 @default.
• W3115300859 cites W2953834653 @default.
• W3115300859 cites W2965641758 @default.
• W3115300859 cites W2980789836 @default.
• W3115300859 cites W2999871274 @default.
• W3115300859 cites W3012283572 @default.
• W3115300859 cites W3012664161 @default.
• W3115300859 cites W3016524771 @default.
• W3115300859 cites W3017286057 @default.
• W3115300859 cites W3023256085 @default.
• W3115300859 cites W3034379618 @default.
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• W3115300859 doi "https://doi.org/10.1210/clinem/dgaa951" @default.
• W3115300859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33382900" @default.
• W3115300859 hasPublicationYear "2020" @default.
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