FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3115305877> ?p ?o ?g. }

• W3115305877 endingPage "388" @default.
• W3115305877 startingPage "378" @default.
• W3115305877 abstract "Abstract Candida haemulonii species complex (C. haemulonii, C. haemulonii var. vulnera and Candida duobushaemulonii) is composed by emerging and multidrug-resistant (MDR) yeasts. Candidiasis, the disease caused by these species, is difficult to treat and culminates in clinical failures and patient death. It is well-known that Candida peptidases play important roles in the fungus–host interactions, and hence these enzymes are promising targets for developing new antifungal drugs. Recently, serine-type peptidases were described in clinical isolates of C. haemulonii complex with the ability to cleave relevant key host proteins. Herein, the effects of serine peptidase inhibitors (SPIs) on the cell biology of this fungal complex were evaluated. Initially, eight distinct SPIs (phenylmethylsulfonyl fluoride – PMSF, 4-(2-aminoethyl) benzenesulfonyl fluoride hydrochloride – AEBSF, N-α-tosyl- l -lysine chloromethyl ketone hydrochloride – TLCK, N-p-tosyl- l -phenylalanine chloromethyl ketone – TPCK, simeprevir, boceprevir, danoprevir and telaprevir) were tested on the fungal growth. TPCK showed the best efficacy in controlling cell proliferation, being selected for the following experiments. This SPI induced changes in the architecture of yeast cells, as observed by scanning electron microscopy, besides injuries at the plasma membrane and reduction in the ergosterol content. TPCK also diminished the ability of yeasts to adhere to abiotic (polystyrene and glass) and biotic (murine macrophages) surfaces in a typically concentration-dependent manner. In addition, the 24 h-treatment of the mature biofilm promoted a decrease in biomass, viability and extracellular matrix. Altogether, our results highlight that SPIs may be promising new therapeutic agents in the treatment of candidiasis caused by emergent, opportunistic and MDR species forming the C. haemulonii complex." @default.
• W3115305877 created "2021-01-05" @default.
• W3115305877 creator A5016983671 @default.
• W3115305877 creator A5048896943 @default.
• W3115305877 creator A5068855331 @default.
• W3115305877 creator A5077084539 @default.
• W3115305877 creator A5091702477 @default.
• W3115305877 date "2021-05-01" @default.
• W3115305877 modified "2023-09-24" @default.
• W3115305877 title "The serine peptidase inhibitor N-ρ-tosyl-l-phenylalanine chloromethyl ketone (TPCK) affects the cell biology of Candida haemulonii species complex" @default.
• W3115305877 cites W1592018621 @default.
• W3115305877 cites W1606473349 @default.
• W3115305877 cites W1760136619 @default.
• W3115305877 cites W1782451125 @default.
• W3115305877 cites W1827553253 @default.
• W3115305877 cites W1848387105 @default.
• W3115305877 cites W1920616981 @default.
• W3115305877 cites W1983260998 @default.
• W3115305877 cites W1984858220 @default.
• W3115305877 cites W1987527077 @default.
• W3115305877 cites W1991370557 @default.
• W3115305877 cites W1992303688 @default.
• W3115305877 cites W2012064808 @default.
• W3115305877 cites W2027821976 @default.
• W3115305877 cites W2027834171 @default.
• W3115305877 cites W2040501093 @default.
• W3115305877 cites W2051490501 @default.
• W3115305877 cites W2058739490 @default.
• W3115305877 cites W2073077939 @default.
• W3115305877 cites W2097910973 @default.
• W3115305877 cites W2099215866 @default.
• W3115305877 cites W2112551385 @default.
• W3115305877 cites W2114370486 @default.
• W3115305877 cites W2118355092 @default.
• W3115305877 cites W2125848302 @default.
• W3115305877 cites W2145158961 @default.
• W3115305877 cites W2156315472 @default.
• W3115305877 cites W2165010118 @default.
• W3115305877 cites W2168526937 @default.
• W3115305877 cites W2169886853 @default.
• W3115305877 cites W2395093176 @default.
• W3115305877 cites W2415066162 @default.
• W3115305877 cites W2508061372 @default.
• W3115305877 cites W2509690356 @default.
• W3115305877 cites W2513973832 @default.
• W3115305877 cites W2572301334 @default.
• W3115305877 cites W2581445534 @default.
• W3115305877 cites W2583705309 @default.
• W3115305877 cites W2584554891 @default.
• W3115305877 cites W2749466225 @default.
• W3115305877 cites W2765871183 @default.
• W3115305877 cites W2795355022 @default.
• W3115305877 cites W2806610516 @default.
• W3115305877 cites W2894281254 @default.
• W3115305877 cites W2899489704 @default.
• W3115305877 cites W2913833947 @default.
• W3115305877 cites W2976554990 @default.
• W3115305877 cites W3004341515 @default.
• W3115305877 doi "https://doi.org/10.1016/j.funbio.2020.12.004" @default.
• W3115305877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33910679" @default.
• W3115305877 hasPublicationYear "2021" @default.
• W3115305877 type Work @default.
• W3115305877 sameAs 3115305877 @default.
• W3115305877 citedByCount "1" @default.
• W3115305877 countsByYear W31153058772023 @default.
• W3115305877 crossrefType "journal-article" @default.
• W3115305877 hasAuthorship W3115305877A5016983671 @default.
• W3115305877 hasAuthorship W3115305877A5048896943 @default.
• W3115305877 hasAuthorship W3115305877A5068855331 @default.
• W3115305877 hasAuthorship W3115305877A5077084539 @default.
• W3115305877 hasAuthorship W3115305877A5091702477 @default.
• W3115305877 hasConcept C178790620 @default.
• W3115305877 hasConcept C181199279 @default.
• W3115305877 hasConcept C185592680 @default.
• W3115305877 hasConcept C2776414213 @default.
• W3115305877 hasConcept C2777431362 @default.
• W3115305877 hasConcept C2777738585 @default.
• W3115305877 hasConcept C2778718427 @default.
• W3115305877 hasConcept C515207424 @default.
• W3115305877 hasConcept C55493867 @default.
• W3115305877 hasConcept C71240020 @default.
• W3115305877 hasConcept C86803240 @default.
• W3115305877 hasConceptScore W3115305877C178790620 @default.
• W3115305877 hasConceptScore W3115305877C181199279 @default.
• W3115305877 hasConceptScore W3115305877C185592680 @default.
• W3115305877 hasConceptScore W3115305877C2776414213 @default.
• W3115305877 hasConceptScore W3115305877C2777431362 @default.
• W3115305877 hasConceptScore W3115305877C2777738585 @default.
• W3115305877 hasConceptScore W3115305877C2778718427 @default.
• W3115305877 hasConceptScore W3115305877C515207424 @default.
• W3115305877 hasConceptScore W3115305877C55493867 @default.
• W3115305877 hasConceptScore W3115305877C71240020 @default.
• W3115305877 hasConceptScore W3115305877C86803240 @default.
• W3115305877 hasFunder F4320321091 @default.
• W3115305877 hasFunder F4320322025 @default.
• W3115305877 hasFunder F4320322749 @default.
• W3115305877 hasIssue "5" @default.
• W3115305877 hasLocation W31153058771 @default.

• next