Matches in SemOpenAlex for { <https://semopenalex.org/work/W3115336492> ?p ?o ?g. }
- W3115336492 abstract "Summary Astrocytes regulate the formation and function of neuronal synapses via multiple signals, however, what controls regional and temporal expression of these signals during development is unknown. We determined the expression profile of astrocyte synapse-regulating genes in the developing mouse visual cortex, identifying astrocyte signals that show differential temporal and layer-enriched expression. These patterns are not intrinsic to astrocytes, but regulated by visually-evoked neuronal activity, as they are absent in mice lacking glutamate release from thalamocortical terminals. Consequently, synapses remain immature. Expression of synapse-regulating genes and synaptic development are also altered when astrocyte signaling is blunted by diminishing calcium release from astrocyte stores. Single nucleus RNA sequencing identified groups of astrocytic genes regulated by neuronal and astrocyte activity, and a cassette of genes that show layer-specific enrichment. Thus, the development of cortical circuits requires coordinated signaling between astrocytes and neurons, identifying astrocytes as a target to manipulate in neurodevelopmental disorders." @default.
- W3115336492 created "2021-01-05" @default.
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- W3115336492 date "2020-12-30" @default.
- W3115336492 modified "2023-10-18" @default.
- W3115336492 title "Activity-Dependent Modulation of Synapse-Regulating Genes in Astrocytes" @default.
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