Matches in SemOpenAlex for { <https://semopenalex.org/work/W3115349511> ?p ?o ?g. }
- W3115349511 endingPage "1260" @default.
- W3115349511 startingPage "1244" @default.
- W3115349511 abstract "Right ventricle (RV) dysfunction is the strongest predictor of mortality in pulmonary arterial hypertension (PAH), but, at present, there are no therapies directly targeting the failing RV. Although there are shared molecular mechanisms in both RV and left ventricle (LV) dysfunction, there are important differences between the 2 ventricles that may allow for the development of RV-enhancing or RV-directed therapies. In this review, we discuss the current understandings of the dysregulated pathways that promote RV dysfunction, highlight RV-enriched or RV-specific pathways that may be of particular therapeutic value, and summarize recent and ongoing clinical trials that are investigating RV function in PAH. It is hoped that development of RV-targeted therapies will improve quality of life and enhance survival for this deadly disease." @default.
- W3115349511 created "2021-01-05" @default.
- W3115349511 creator A5054612339 @default.
- W3115349511 creator A5060590034 @default.
- W3115349511 creator A5065609548 @default.
- W3115349511 date "2020-12-01" @default.
- W3115349511 modified "2023-10-06" @default.
- W3115349511 title "Treatment Targets for Right Ventricular Dysfunction in Pulmonary Arterial Hypertension" @default.
- W3115349511 cites W1546492882 @default.
- W3115349511 cites W1737536869 @default.
- W3115349511 cites W1754124925 @default.
- W3115349511 cites W1790526358 @default.
- W3115349511 cites W1815197835 @default.
- W3115349511 cites W1828700258 @default.
- W3115349511 cites W1912054520 @default.
- W3115349511 cites W1918193374 @default.
- W3115349511 cites W1944669821 @default.
- W3115349511 cites W1965271063 @default.
- W3115349511 cites W1968417276 @default.
- W3115349511 cites W1968814354 @default.
- W3115349511 cites W1970248508 @default.
- W3115349511 cites W1970771731 @default.
- W3115349511 cites W1980402405 @default.
- W3115349511 cites W1982661764 @default.
- W3115349511 cites W1984472171 @default.
- W3115349511 cites W1984693219 @default.
- W3115349511 cites W1989649500 @default.
- W3115349511 cites W1992250427 @default.
- W3115349511 cites W1995628893 @default.
- W3115349511 cites W1998562191 @default.
- W3115349511 cites W1999987967 @default.
- W3115349511 cites W2002636102 @default.
- W3115349511 cites W2002919375 @default.
- W3115349511 cites W2004672853 @default.
- W3115349511 cites W2012608566 @default.
- W3115349511 cites W2014500068 @default.
- W3115349511 cites W2015945747 @default.
- W3115349511 cites W2018124947 @default.
- W3115349511 cites W2022060260 @default.
- W3115349511 cites W2023314610 @default.
- W3115349511 cites W2023455251 @default.
- W3115349511 cites W2025717255 @default.
- W3115349511 cites W2033058019 @default.
- W3115349511 cites W2038311789 @default.
- W3115349511 cites W2039166200 @default.
- W3115349511 cites W2039518943 @default.
- W3115349511 cites W2041492515 @default.
- W3115349511 cites W2041972892 @default.
- W3115349511 cites W2043841603 @default.
- W3115349511 cites W2044032429 @default.
- W3115349511 cites W2045856536 @default.
- W3115349511 cites W2046683032 @default.
- W3115349511 cites W2057756640 @default.
- W3115349511 cites W2058021996 @default.
- W3115349511 cites W2062002285 @default.
- W3115349511 cites W2063757197 @default.
- W3115349511 cites W2067152340 @default.
- W3115349511 cites W2074461681 @default.
- W3115349511 cites W2075575242 @default.
- W3115349511 cites W2076641973 @default.
- W3115349511 cites W2078855026 @default.
- W3115349511 cites W2080694717 @default.
- W3115349511 cites W2080996739 @default.
- W3115349511 cites W2081204328 @default.
- W3115349511 cites W2082076982 @default.
- W3115349511 cites W2084064095 @default.
- W3115349511 cites W2092301324 @default.
- W3115349511 cites W2096223780 @default.
- W3115349511 cites W2100165029 @default.
- W3115349511 cites W2100301312 @default.
- W3115349511 cites W2100584927 @default.
- W3115349511 cites W2106321093 @default.
- W3115349511 cites W2106815412 @default.
- W3115349511 cites W2107471172 @default.
- W3115349511 cites W2110724436 @default.
- W3115349511 cites W2114863766 @default.
- W3115349511 cites W2115446927 @default.
- W3115349511 cites W2115978936 @default.
- W3115349511 cites W2116775624 @default.
- W3115349511 cites W2117339256 @default.
- W3115349511 cites W2119340816 @default.
- W3115349511 cites W2119852489 @default.
- W3115349511 cites W2120763518 @default.
- W3115349511 cites W2122053152 @default.
- W3115349511 cites W2122188617 @default.
- W3115349511 cites W2124549031 @default.
- W3115349511 cites W2124870395 @default.
- W3115349511 cites W2125939035 @default.
- W3115349511 cites W2128867957 @default.
- W3115349511 cites W2130290719 @default.
- W3115349511 cites W2134034292 @default.
- W3115349511 cites W2136504228 @default.
- W3115349511 cites W2136978968 @default.
- W3115349511 cites W2137779787 @default.
- W3115349511 cites W2142064271 @default.
- W3115349511 cites W2142109050 @default.
- W3115349511 cites W2142645644 @default.
- W3115349511 cites W2143766037 @default.