FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3115354805> ?p ?o ?g. }

• W3115354805 abstract "Abstract Objective To evaluate whether longitudinal measurements of serological adipokines and sphingolipids can predict preeclampsia early in gestation. Design Retrospective multi-omics discovery and longitudinal validation. Setting Maternity units in two US hospitals. Methods A multi-omics approach integrating genomic and lipidomic discoveries was employed to identify leptin (Lep) and ceramide (Cer) as novel PE early gestational biomarkers. The levels of placental growth factor (PlGF), soluble fms-like tyrosine kinase (sFlt-1), Lep, and Cer in maternal sera were then determined by enzyme-linked immunosorbent (ELISA) and liquid chromatography-tandem mass spectrometric (LC/MS/MS) assays. Main outcome measures Interval from positive prediction to confirmative diagnosis. Results Genomic meta-analysis compiled six PE placental cohorts with 78 PE and 95 non-PE control placentas. The Testing Cohort included sera from 7 non-PE and 8 PE women collected at confirmatory diagnosis. The Validation Cohort included sera from 20 non-PE and 20 PE women collected longitudinally through gestation. Our findings revealed a marked elevation of maternal serum Leptin/Ceramide (d18:1/25:0) ratio from early gestation (a median of 23 weeks) when comparing later PE-complicated with uncomplicated pregnancies. The maternal Lep/Cer (d18:1/25:0) ratio significantly outperformed the established sFlt-1/PlGF ratio in predicting PE for sensitivity (85% vs. 40%), positive predictive value (89% vs. 42%), and AUC (0.92 vs. 0.52) from 5 to 25 weeks of gestation. Conclusions Non-invasive longitudinal assessment by serological evaluation of Lep/Cer (d18:1/25:0) ratio can case find early pregnancies at risk of preeclampsia, outperforming sFlt-1/PlGF ratio test. Tweetable abstract Non-invasive longitudinal assessment by serological evaluation of Lep and Cer ratio can predict preeclampsia early in gestation." @default.
• W3115354805 created "2021-01-05" @default.
• W3115354805 creator A5009212787 @default.
• W3115354805 creator A5009414181 @default.
• W3115354805 creator A5010444377 @default.
• W3115354805 creator A5013742088 @default.
• W3115354805 creator A5015037150 @default.
• W3115354805 creator A5023366565 @default.
• W3115354805 creator A5025548835 @default.
• W3115354805 creator A5027272747 @default.
• W3115354805 creator A5033044395 @default.
• W3115354805 creator A5036633860 @default.
• W3115354805 creator A5054009158 @default.
• W3115354805 creator A5055733234 @default.
• W3115354805 creator A5059155864 @default.
• W3115354805 creator A5063792544 @default.
• W3115354805 creator A5067320192 @default.
• W3115354805 creator A5068897129 @default.
• W3115354805 creator A5073192279 @default.
• W3115354805 creator A5080843935 @default.
• W3115354805 creator A5086681109 @default.
• W3115354805 date "2020-12-19" @default.
• W3115354805 modified "2023-09-22" @default.
• W3115354805 title "Case finding of early pregnancies at risk of preeclampsia using maternal blood leptin/ceramide ratio: multi-omics discovery and validation from a longitudinal study" @default.
• W3115354805 cites W1460322155 @default.
• W3115354805 cites W1714905593 @default.
• W3115354805 cites W1874766814 @default.
• W3115354805 cites W1965017587 @default.
• W3115354805 cites W1978940943 @default.
• W3115354805 cites W1979464484 @default.
• W3115354805 cites W1990795537 @default.
• W3115354805 cites W2000561567 @default.
• W3115354805 cites W2001295429 @default.
• W3115354805 cites W2005298277 @default.
• W3115354805 cites W2011810052 @default.
• W3115354805 cites W2011916431 @default.
• W3115354805 cites W2016526819 @default.
• W3115354805 cites W2031158353 @default.
• W3115354805 cites W2035483520 @default.
• W3115354805 cites W2059849577 @default.
• W3115354805 cites W2062975821 @default.
• W3115354805 cites W2066074894 @default.
• W3115354805 cites W2071927361 @default.
• W3115354805 cites W2078052974 @default.
• W3115354805 cites W2086410640 @default.
• W3115354805 cites W2093826817 @default.
• W3115354805 cites W2094603106 @default.
• W3115354805 cites W2100028812 @default.
• W3115354805 cites W2101921785 @default.
• W3115354805 cites W2107797512 @default.
• W3115354805 cites W2109289772 @default.
• W3115354805 cites W2115664813 @default.
• W3115354805 cites W2115968274 @default.
• W3115354805 cites W2134874094 @default.
• W3115354805 cites W2136382330 @default.
• W3115354805 cites W2156182815 @default.
• W3115354805 cites W2156417112 @default.
• W3115354805 cites W2161969333 @default.
• W3115354805 cites W2162325336 @default.
• W3115354805 cites W2169293642 @default.
• W3115354805 cites W2308831276 @default.
• W3115354805 cites W2322909744 @default.
• W3115354805 cites W2340348123 @default.
• W3115354805 cites W2504871172 @default.
• W3115354805 cites W2514898011 @default.
• W3115354805 cites W2561810583 @default.
• W3115354805 cites W2583633091 @default.
• W3115354805 cites W2617618349 @default.
• W3115354805 cites W2618617063 @default.
• W3115354805 cites W2625529638 @default.
• W3115354805 cites W2755261455 @default.
• W3115354805 cites W2769717261 @default.
• W3115354805 cites W2794329614 @default.
• W3115354805 cites W2810668594 @default.
• W3115354805 cites W2887193059 @default.
• W3115354805 cites W2910720169 @default.
• W3115354805 cites W2916697167 @default.
• W3115354805 cites W2929300773 @default.
• W3115354805 cites W2948812843 @default.
• W3115354805 cites W2954729572 @default.
• W3115354805 cites W2984689747 @default.
• W3115354805 cites W2998683449 @default.
• W3115354805 cites W3003112162 @default.
• W3115354805 cites W3005308306 @default.
• W3115354805 cites W3009787933 @default.
• W3115354805 cites W3088213833 @default.
• W3115354805 cites W4205489241 @default.
• W3115354805 cites W4211054086 @default.
• W3115354805 cites W4238245857 @default.
• W3115354805 cites W4240524091 @default.
• W3115354805 cites W4249550771 @default.
• W3115354805 doi "https://doi.org/10.1101/2020.12.17.20248418" @default.
• W3115354805 hasPublicationYear "2020" @default.
• W3115354805 type Work @default.
• W3115354805 sameAs 3115354805 @default.
• W3115354805 citedByCount "0" @default.
• W3115354805 crossrefType "posted-content" @default.
• W3115354805 hasAuthorship W3115354805A5009212787 @default.
• W3115354805 hasAuthorship W3115354805A5009414181 @default.
• W3115354805 hasAuthorship W3115354805A5010444377 @default.

• next