Matches in SemOpenAlex for { <https://semopenalex.org/work/W3115373086> ?p ?o ?g. }
- W3115373086 endingPage "115196" @default.
- W3115373086 startingPage "115196" @default.
- W3115373086 abstract "Abstract Pepsin is an aspartic proteinase that plays an essential role in controlling many biological processes, therapy, and pharmaceutical research. Catechins belong to the group of polyphenols that are the most basic chemical composition of green tea. If catechin gets into the human stomach, the binding targets may be the digestive protease. This paper focuses on the behavior of the pepsin enzyme onto the green tea polyphenol, (+)-catechin hydrate. The effects of catechin hydrate on the structure and activity of pepsin were done utilizing ultraviolet−visible (UV–Vis) spectroscopy, intrinsic fluorescence spectroscopy, circular dichroism (CD), thermal stability, kinetic techniques, as well as molecular docking, and Molecular dynamic simulations (MD) technique. The experimental results from fluorescence spectroscopy revealed that the alterations in pepsin's tertiary structure were caused by catechin hydrate binding. The apparent binding constant Ka, the number of binding sites, and thermodynamic parameters were calculated at three different temperatures. Thermodynamic results revealed that catechin hydrate interacts with pepsin spontaneously by hydrophobic forces. The result of the circular dichroism spectral suggests the secondary structural changes. An increase in the content of the β-turn structure was shown. Kinetic parameters revealed that catechin hydrate inhibited the activity of pepsin. The Molecular dynamic (MD) and docking simulations supported experimental findings. As a result, catechin hydrate could be considered as an inhibitor with adverse effects on pepsin structure and function." @default.
- W3115373086 created "2021-01-05" @default.
- W3115373086 creator A5043543916 @default.
- W3115373086 creator A5060419630 @default.
- W3115373086 creator A5079008796 @default.
- W3115373086 date "2021-03-01" @default.
- W3115373086 modified "2023-10-02" @default.
- W3115373086 title "The interaction of the green tea polyphenol (catechin) with pepsin: Insights from spectroscopic to molecular dynamics studies" @default.
- W3115373086 cites W1841155685 @default.
- W3115373086 cites W1946640588 @default.
- W3115373086 cites W1966078827 @default.
- W3115373086 cites W1981157132 @default.
- W3115373086 cites W1983660868 @default.
- W3115373086 cites W1988696784 @default.
- W3115373086 cites W1991379964 @default.
- W3115373086 cites W1994344551 @default.
- W3115373086 cites W2010912389 @default.
- W3115373086 cites W2018268596 @default.
- W3115373086 cites W2028606216 @default.
- W3115373086 cites W2029558077 @default.
- W3115373086 cites W2050106750 @default.
- W3115373086 cites W2056538157 @default.
- W3115373086 cites W2075503331 @default.
- W3115373086 cites W2089695888 @default.
- W3115373086 cites W2105668062 @default.
- W3115373086 cites W2132629607 @default.
- W3115373086 cites W2144522670 @default.
- W3115373086 cites W2161034194 @default.
- W3115373086 cites W2163577688 @default.
- W3115373086 cites W2167956909 @default.
- W3115373086 cites W2171268876 @default.
- W3115373086 cites W2285348003 @default.
- W3115373086 cites W2345913675 @default.
- W3115373086 cites W2404227542 @default.
- W3115373086 cites W2507553664 @default.
- W3115373086 cites W2565383127 @default.
- W3115373086 cites W2615320508 @default.
- W3115373086 cites W2739080658 @default.
- W3115373086 cites W2794599464 @default.
- W3115373086 cites W2800966632 @default.
- W3115373086 cites W2803438754 @default.
- W3115373086 cites W2886514655 @default.
- W3115373086 cites W2899357928 @default.
- W3115373086 cites W2912535974 @default.
- W3115373086 cites W2921277877 @default.
- W3115373086 cites W2922290642 @default.
- W3115373086 cites W2944122933 @default.
- W3115373086 cites W2949430484 @default.
- W3115373086 cites W2956321023 @default.
- W3115373086 cites W2964348031 @default.
- W3115373086 cites W2967083834 @default.
- W3115373086 cites W2967391420 @default.
- W3115373086 cites W2969734675 @default.
- W3115373086 cites W2999541087 @default.
- W3115373086 cites W3005377059 @default.
- W3115373086 cites W3087617638 @default.
- W3115373086 cites W3092705762 @default.
- W3115373086 doi "https://doi.org/10.1016/j.molliq.2020.115196" @default.
- W3115373086 hasPublicationYear "2021" @default.
- W3115373086 type Work @default.
- W3115373086 sameAs 3115373086 @default.
- W3115373086 citedByCount "28" @default.
- W3115373086 countsByYear W31153730862021 @default.
- W3115373086 countsByYear W31153730862022 @default.
- W3115373086 countsByYear W31153730862023 @default.
- W3115373086 crossrefType "journal-article" @default.
- W3115373086 hasAuthorship W3115373086A5043543916 @default.
- W3115373086 hasAuthorship W3115373086A5060419630 @default.
- W3115373086 hasAuthorship W3115373086A5079008796 @default.
- W3115373086 hasConcept C121332964 @default.
- W3115373086 hasConcept C145912823 @default.
- W3115373086 hasConcept C147597530 @default.
- W3115373086 hasConcept C16311235 @default.
- W3115373086 hasConcept C178790620 @default.
- W3115373086 hasConcept C181199279 @default.
- W3115373086 hasConcept C185592680 @default.
- W3115373086 hasConcept C24890656 @default.
- W3115373086 hasConcept C2778004101 @default.
- W3115373086 hasConcept C2779431889 @default.
- W3115373086 hasConcept C2992814287 @default.
- W3115373086 hasConcept C31903555 @default.
- W3115373086 hasConcept C59593255 @default.
- W3115373086 hasConcept C70899900 @default.
- W3115373086 hasConcept C71240020 @default.
- W3115373086 hasConceptScore W3115373086C121332964 @default.
- W3115373086 hasConceptScore W3115373086C145912823 @default.
- W3115373086 hasConceptScore W3115373086C147597530 @default.
- W3115373086 hasConceptScore W3115373086C16311235 @default.
- W3115373086 hasConceptScore W3115373086C178790620 @default.
- W3115373086 hasConceptScore W3115373086C181199279 @default.
- W3115373086 hasConceptScore W3115373086C185592680 @default.
- W3115373086 hasConceptScore W3115373086C24890656 @default.
- W3115373086 hasConceptScore W3115373086C2778004101 @default.
- W3115373086 hasConceptScore W3115373086C2779431889 @default.
- W3115373086 hasConceptScore W3115373086C2992814287 @default.
- W3115373086 hasConceptScore W3115373086C31903555 @default.
- W3115373086 hasConceptScore W3115373086C59593255 @default.
- W3115373086 hasConceptScore W3115373086C70899900 @default.