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• W3115412306 endingPage "144249" @default.
• W3115412306 startingPage "144249" @default.
• W3115412306 abstract "Nanoplastics are a growing environmental and public health concern. However, the toxic mechanisms of nanoplastics are poorly understood. Here, we evaluated the effects of spherical polystyrene nanoplastics on reproduction of Daphnia pulex and analyzed the proteome of whole animals followed by molecular and biochemical analyses for the development of an adverse outcome pathway (AOP) for these contaminants of emerging concern. Animals were exposed to polystyrene nanoplastics (0, 0.1, 0.5, 1 and 2 mg/L) via water for 21 days. Nanoplastics negatively impacted cumulative offspring production. A total of 327 differentially expressed proteins (DEPs) were identified in response to nanoplastics which were further validated from gene expression and enzyme activity data. Based on these results, we propose an AOP for nanoplastics, including radical oxygen species production and oxidative stress as the molecular initiating event (MIE); followed by changes in specific signaling pathways (Jak-STAT, mTOR and FoxO) and in the metabolism of glutathione, protein, lipids, and molting proteins; with an end result of growth inhibition and decrease reproductive output. This study serves as a foundation for the development of a mechanistic understanding of nanoplastic toxicity in crustaceans and perhaps other aquatic organisms." @default.
• W3115412306 created "2021-01-05" @default.
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• W3115412306 date "2021-04-01" @default.
• W3115412306 modified "2023-10-15" @default.
• W3115412306 title "Development of an adverse outcome pathway for nanoplastic toxicity in Daphnia pulex using proteomics" @default.
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• W3115412306 cites W2000089305 @default.
• W3115412306 cites W2002874592 @default.
• W3115412306 cites W2004854975 @default.
• W3115412306 cites W2011923115 @default.
• W3115412306 cites W2032922774 @default.
• W3115412306 cites W2037199116 @default.
• W3115412306 cites W2037496050 @default.
• W3115412306 cites W2039970884 @default.
• W3115412306 cites W2043722033 @default.
• W3115412306 cites W2045907249 @default.
• W3115412306 cites W2050786959 @default.
• W3115412306 cites W2051121620 @default.
• W3115412306 cites W2053555116 @default.
• W3115412306 cites W2058484936 @default.
• W3115412306 cites W2061918707 @default.
• W3115412306 cites W2062780428 @default.
• W3115412306 cites W2066767398 @default.
• W3115412306 cites W2068589796 @default.
• W3115412306 cites W2085831882 @default.
• W3115412306 cites W2099364141 @default.
• W3115412306 cites W2102021233 @default.
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• W3115412306 cites W2133405889 @default.
• W3115412306 cites W2157803823 @default.
• W3115412306 cites W2159659449 @default.
• W3115412306 cites W2162857699 @default.
• W3115412306 cites W2174156150 @default.
• W3115412306 cites W2255762950 @default.
• W3115412306 cites W2296287575 @default.
• W3115412306 cites W2313757172 @default.
• W3115412306 cites W2319381398 @default.
• W3115412306 cites W2324360527 @default.
• W3115412306 cites W2357845632 @default.
• W3115412306 cites W2413261018 @default.
• W3115412306 cites W2414305648 @default.
• W3115412306 cites W2598194399 @default.
• W3115412306 cites W2607306190 @default.
• W3115412306 cites W2619322372 @default.
• W3115412306 cites W2757494848 @default.
• W3115412306 cites W2789431247 @default.
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• W3115412306 cites W2809296139 @default.
• W3115412306 cites W2888234913 @default.
• W3115412306 cites W2894631038 @default.
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• W3115412306 cites W2968062905 @default.
• W3115412306 cites W2968310455 @default.
• W3115412306 cites W2969800204 @default.
• W3115412306 cites W2972727278 @default.
• W3115412306 cites W2979700668 @default.
• W3115412306 cites W2981461435 @default.
• W3115412306 cites W2982618489 @default.
• W3115412306 cites W2985310169 @default.
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• W3115412306 doi "https://doi.org/10.1016/j.scitotenv.2020.144249" @default.
• W3115412306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33421781" @default.
• W3115412306 hasPublicationYear "2021" @default.
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