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• W3115419007 endingPage "101842" @default.
• W3115419007 startingPage "101842" @default.
• W3115419007 abstract "In the Wnt canonical pathway, Wnt3A has been known to stabilize β-catenin. In the non-canonical Wnt signaling pathway, Wnt is known to activate Rho GTPases. The correlation between canonical and non-canonical pathways by Wnt signaling, however, has not been well elucidated. Here, we identified that Wnt3A promoted superoxide generation, leading to Tyr42 phosphorylation of RhoA through activations of c-Src and Rho-dependent coiled coil kinase 2 (ROCK2) and phosphorylation of p47phox, a component of NADPH oxidase. Wnt3A also induced accumulation of β-catenin along with activations of RhoA and ROCK1. Concurrently, ROCK1 was able to phosphorylate GSK-3β at Ser9, which phosphorylated Src at Ser51 and Ser492 residues, leading to Src inactivation through dephosphorylation of Tyr416 during the late period of Wnt3A treatment. Meanwhile, p-Tyr42 RhoA bound to β-catenin via the N-terminal domain of β-catenin, thereby leading to the nuclear translocation of p-Tyr42 RhoA/β-catenin complex. Notably, p-Tyr42 RhoA as well as β-catenin was associated with the promoter of Vim, leading to increased expression of vimentin. In addition, stomach cancer patients harboring higher expressed p-Tyr42 Rho levels revealed the much poorer survival probability. Therefore, we propose that p-Tyr42 RhoA is crucial for transcriptional regulation of specific target genes in the nucleus by binding to their promoters and involved in tumorigenesis." @default.
• W3115419007 created "2021-01-05" @default.
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• W3115419007 date "2021-04-01" @default.
• W3115419007 modified "2023-10-12" @default.
• W3115419007 title "RhoA GTPase phosphorylated at tyrosine 42 by src kinase binds to β-catenin and contributes transcriptional regulation of vimentin upon Wnt3A" @default.
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• W3115419007 doi "https://doi.org/10.1016/j.redox.2020.101842" @default.
• W3115419007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7788234" @default.
• W3115419007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33388549" @default.
• W3115419007 hasPublicationYear "2021" @default.
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