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• W3115508938 abstract "Oligonucleotide (ON) conjugates are increasingly important tools for various molecular diagnostics, nanotechnological applications, and for the development of nucleic acid-based therapies. Multiple labeling of ONs can further equip ON-conjugates and provide improved or additional tailored properties. Typically, the preparation of ON multiconjugates involves additional synthetic steps and/or manipulations in post-ON assembly. This report describes the simplified methodology allowing for multiple labeling of ONs on a solid support and is compatible with phosphodiester as well as phosphorothioate (PS) ONs. The current approach utilizes two novel alkyne- and amino-functionalized linker phosphoramidites that can be readily synthesized from a common aminodiol intermediate in three steps. The combination of new linkers provides orthogonal functionalities, which allow for multiple attachments of similar or varied moieties. The linkers are incorporated into ONs during automated solid-phase ON synthesis, and the conjugation with functional entities is achieved by either amide bond formation or by copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC). The versatility of the approach is demonstrated by the synthesis of 5′-site ON multiconjugates with small molecules, peptides, and fatty acids as well as in the preparation of an internal peptide–ON conjugate." @default.
• W3115508938 created "2021-01-05" @default.
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• W3115508938 date "2020-12-18" @default.
• W3115508938 modified "2023-10-17" @default.
• W3115508938 title "New Alkyne and Amine Linkers for Versatile Multiple Conjugation of Oligonucleotides" @default.
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• W3115508938 doi "https://doi.org/10.1021/acsomega.0c05075" @default.
• W3115508938 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7807750" @default.
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• W3115508938 hasPublicationYear "2020" @default.
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