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• W3115568909 abstract "External support stent is a potential means for restricting the deformation and reducing wall stress of the vein graft, thereby improving the long-term patency of the graft in coronary artery bypass surgery. However, there still lacks a theoretical reference for choosing the size of stent based on the diameter of graft. Taking the VEST (venous external support) stent currently used in the clinical practice as the object of study, we constructed three models of VEST stents with different diameters and coupled them respectively to a model of the great saphenous vein graft, and numerically simulated the expansion-contraction process of the vein graft under the constraint of the stents to quantitatively evaluate the influence of stent size on the radial deformation and wall stress of the vein graft. The results showed that while the stent with a small diameter had a high restrictive effect in comparison with larger stents, it led to more severe concentration of wall stress and sharper changes in radial deformation along the axis of the graft, which may have adverse influence on the graft. In order to solve the aforementioned problems, we ameliorated the design of the stent by means of changing the cross-sectional shape of the thick and thin alloy wires from circle into rectangle and square, respectively, while keeping the cross-sectional areas of alloy wires and stent topology unchanged. Further numerical simulations demonstrated that the ameliorated stent evidently reduced the degrees of wall stress concentration and abrupt changes in radial deformation, which may help improve the biomechanical environment of the graft while maintaining the restrictive role of the stent.血管外支架是冠脉搭桥术中用于约束静脉桥形变和降低管壁应力从而提高桥血管长期通畅率的潜在手段。然而，如何根据静脉桥的直径选择支架尺寸仍缺乏理论参考。本文以临床上使用的 VEST 静脉外支架为研究对象，构建三种不同直径的 VEST 支架与大隐静脉桥血管的耦合模型，数值模拟支架约束下静脉桥的膨胀收缩过程，量化评价支架尺寸对静脉桥径向变形和管壁应力的影响。结果表明，支架直径较小时其约束作用较为明显，但与较大直径的支架相比，在静脉桥轴向存在更为显著的应力集中和径向变形量突变现象，可能对桥血管产生不良影响。为了解决上述问题，本文对 VEST 支架进行改良设计，即在保持支架的合金丝横截面积和拓扑结构不变的前提下，将粗、细合金丝的截面形状由圆形分别变为矩形和正方形。进一步的数值模拟研究表明，改良设计后的支架可以明显降低应力集中和管径变形量突变的程度，有助于在保持支架约束作用的同时改善桥血管的生物力学环境。." @default.
• W3115568909 created "2021-01-05" @default.
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• W3115568909 date "2020-12-25" @default.
• W3115568909 modified "2023-09-25" @default.
• W3115568909 title "[Numerical study on the mechanical coupling of external vascular stent and vein graft in coronary artery bypass surgery]." @default.
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• W3115568909 doi "https://doi.org/10.7507/1001-5515.202009070" @default.
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