FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3115625262> ?p ?o ?g. }

• W3115625262 endingPage "101220" @default.
• W3115625262 startingPage "101220" @default.
• W3115625262 abstract "People with cardiovascular disease or risk factors are at increased risk when exposed to SARS-CoV-2. Most are treated with statins, but the impact of these drugs on clinical outcomes of COVID-19 remains unclear. This report is therefore based on meta-analyses of retrospective observational studies aimed at investigating the impact of previous statin therapy in patients hospitalized for COVID-19.In studies reporting on the clinical outcomes of COVID-19 in statin users vs non-users, two endpoints have been used-in-hospital death rates, and disease severity as assessed by admission to intensive care units (ICUs)-with a special focus on patients with diabetes.Regarding mortality, 13 studies were included in the meta-analysis for a total of 10,829 statin users (2517 deaths) and 31,893 non-users (7516 deaths): univariate analysis showed no statistically significant reduction in deaths (OR: 0.97, 95% CI: 0.92-1.03), although between-study heterogeneity was high (I² = 97%). As for disease severity, 11 studies were selected for a total of 3462 statin users (724 endpoints) and 10,560 non-users (1763 endpoints): here again, univariate analysis showed no reduction in severity (OR: 1.09, 95% CI: 0.99-1.22; I² = 93%). Collectively, in 10 studies using multivariable analysis adjusted for the more prevalent baseline risk factors among statin users, lower OR values were reported than with univariate analyses (0.73 ± 0.31 vs 1.44 ± 0.84, respectively; P = 0.0028; adjusted OR: P = 0.0237 vs non-users). Limited but conflicting findings were observed for diabetes patients.Although no significant reductions in either in-hospital mortality or COVID-19 severity were reported among statin users compared with non-users after univariate comparisons, such reductions were observed after adjusting for confounding factors. These highly heterogeneous observational findings now require confirmation by ongoing randomized clinical trials." @default.
• W3115625262 created "2021-01-05" @default.
• W3115625262 creator A5039563874 @default.
• W3115625262 date "2021-11-01" @default.
• W3115625262 modified "2023-10-11" @default.
• W3115625262 title "Statins and clinical outcomes with COVID-19: Meta-analyses of observational studies" @default.
• W3115625262 cites W1909441690 @default.
• W3115625262 cites W1990609541 @default.
• W3115625262 cites W2005971628 @default.
• W3115625262 cites W2014527201 @default.
• W3115625262 cites W2126708809 @default.
• W3115625262 cites W2134497001 @default.
• W3115625262 cites W2152165117 @default.
• W3115625262 cites W2156506016 @default.
• W3115625262 cites W2399289017 @default.
• W3115625262 cites W2792345506 @default.
• W3115625262 cites W2885500852 @default.
• W3115625262 cites W2894810674 @default.
• W3115625262 cites W2900829362 @default.
• W3115625262 cites W2909765747 @default.
• W3115625262 cites W2953804067 @default.
• W3115625262 cites W2970469538 @default.
• W3115625262 cites W3013442544 @default.
• W3115625262 cites W3013949914 @default.
• W3115625262 cites W3014808081 @default.
• W3115625262 cites W3015290603 @default.
• W3115625262 cites W3016493664 @default.
• W3115625262 cites W3020646040 @default.
• W3115625262 cites W3022330946 @default.
• W3115625262 cites W3022331416 @default.
• W3115625262 cites W3023838751 @default.
• W3115625262 cites W3024483427 @default.
• W3115625262 cites W3024705102 @default.
• W3115625262 cites W3025091645 @default.
• W3115625262 cites W3025663760 @default.
• W3115625262 cites W3026318400 @default.
• W3115625262 cites W3027725279 @default.
• W3115625262 cites W3027918021 @default.
• W3115625262 cites W3030700284 @default.
• W3115625262 cites W3034872024 @default.
• W3115625262 cites W3035860713 @default.
• W3115625262 cites W3035931817 @default.
• W3115625262 cites W3035970481 @default.
• W3115625262 cites W3036683212 @default.
• W3115625262 cites W3041886785 @default.
• W3115625262 cites W3041985244 @default.
• W3115625262 cites W3042557581 @default.
• W3115625262 cites W3043611547 @default.
• W3115625262 cites W3043773740 @default.
• W3115625262 cites W3044463005 @default.
• W3115625262 cites W3044846600 @default.
• W3115625262 cites W3046353513 @default.
• W3115625262 cites W3046793840 @default.
• W3115625262 cites W3048010838 @default.
• W3115625262 cites W3048268189 @default.
• W3115625262 cites W3048686971 @default.
• W3115625262 cites W3048804923 @default.
• W3115625262 cites W3048853848 @default.
• W3115625262 cites W3080527067 @default.
• W3115625262 cites W3083980445 @default.
• W3115625262 cites W3084261653 @default.
• W3115625262 cites W3085824346 @default.
• W3115625262 cites W3086301763 @default.
• W3115625262 cites W3086446357 @default.
• W3115625262 cites W3086590814 @default.
• W3115625262 cites W3087417715 @default.
• W3115625262 cites W3088575047 @default.
• W3115625262 cites W3088802374 @default.
• W3115625262 cites W3089981048 @default.
• W3115625262 cites W3090033771 @default.
• W3115625262 cites W3090814857 @default.
• W3115625262 cites W3092290512 @default.
• W3115625262 cites W3092623650 @default.
• W3115625262 cites W3092859401 @default.
• W3115625262 cites W3092997163 @default.
• W3115625262 cites W3093064593 @default.
• W3115625262 cites W3093218972 @default.
• W3115625262 cites W3093529302 @default.
• W3115625262 cites W3094572469 @default.
• W3115625262 cites W3095957974 @default.
• W3115625262 cites W3097133327 @default.
• W3115625262 cites W3097402994 @default.
• W3115625262 cites W3105080096 @default.
• W3115625262 cites W3105827253 @default.
• W3115625262 cites W3106704402 @default.
• W3115625262 cites W3111023021 @default.
• W3115625262 cites W3132610875 @default.
• W3115625262 cites W3183857127 @default.
• W3115625262 doi "https://doi.org/10.1016/j.diabet.2020.101220" @default.
• W3115625262 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7757378" @default.
• W3115625262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33359486" @default.
• W3115625262 hasPublicationYear "2021" @default.
• W3115625262 type Work @default.
• W3115625262 sameAs 3115625262 @default.
• W3115625262 citedByCount "34" @default.
• W3115625262 countsByYear W31156252622021 @default.
• W3115625262 countsByYear W31156252622022 @default.
• W3115625262 countsByYear W31156252622023 @default.

• next