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- W3115672273 endingPage "149" @default.
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- W3115672273 abstract "The endocannabinoid system (ECS) is involved in a wide range of biological functions and comprises cannabinoid receptors and enzymes responsible for endocannabinoid synthesis and degradation. Over the past 2 decades, significant advances toward developing drugs and positron emission tomography (PET) tracers targeting different components of the ECS have been made. Herein, we summarized the recent development of PET tracers for imaging cannabinoid receptors 1 (CB1R) and 2 (CB2R) as well as the key enzymes monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), particularly focusing on PET neuroimaging applications. State-of-the-art PET tracers for the ECS will be reviewed including their chemical design, pharmacological properties, radiolabeling, as well as preclinical and human PET imaging. In addition, this review addresses the current challenges for ECS PET biomarker development and highlights the important role of PET ligands to study disease pathophysiology as well as to facilitate drug discovery." @default.
- W3115672273 created "2021-01-05" @default.
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- W3115672273 date "2020-12-31" @default.
- W3115672273 modified "2023-10-16" @default.
- W3115672273 title "Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development" @default.
- W3115672273 cites W1005113303 @default.
- W3115672273 cites W1160137332 @default.
- W3115672273 cites W1480176511 @default.
- W3115672273 cites W1482026204 @default.
- W3115672273 cites W1494529338 @default.
- W3115672273 cites W1497915593 @default.
- W3115672273 cites W1500032029 @default.
- W3115672273 cites W1514512591 @default.
- W3115672273 cites W1534942440 @default.
- W3115672273 cites W1801725150 @default.
- W3115672273 cites W1828602387 @default.
- W3115672273 cites W1891867118 @default.
- W3115672273 cites W1896248600 @default.
- W3115672273 cites W1945751328 @default.
- W3115672273 cites W1963736429 @default.
- W3115672273 cites W1964148341 @default.
- W3115672273 cites W1964564099 @default.
- W3115672273 cites W1968540803 @default.
- W3115672273 cites W1970726138 @default.
- W3115672273 cites W1971199570 @default.
- W3115672273 cites W1971202406 @default.
- W3115672273 cites W1971466205 @default.
- W3115672273 cites W1975039616 @default.
- W3115672273 cites W1975138972 @default.
- W3115672273 cites W1976376430 @default.
- W3115672273 cites W1979279465 @default.
- W3115672273 cites W1982429227 @default.
- W3115672273 cites W1983611759 @default.
- W3115672273 cites W1988517047 @default.
- W3115672273 cites W1988952674 @default.
- W3115672273 cites W1989155012 @default.
- W3115672273 cites W1989289560 @default.
- W3115672273 cites W1991536699 @default.
- W3115672273 cites W1992243124 @default.
- W3115672273 cites W1993041600 @default.
- W3115672273 cites W1994177552 @default.
- W3115672273 cites W1995552285 @default.
- W3115672273 cites W1996630405 @default.
- W3115672273 cites W1999822411 @default.
- W3115672273 cites W1999879202 @default.
- W3115672273 cites W2002355116 @default.
- W3115672273 cites W2002535987 @default.
- W3115672273 cites W2008402379 @default.
- W3115672273 cites W2015426635 @default.
- W3115672273 cites W2016871471 @default.
- W3115672273 cites W2017486246 @default.
- W3115672273 cites W2018810438 @default.
- W3115672273 cites W2019387110 @default.
- W3115672273 cites W2024104897 @default.
- W3115672273 cites W2026413049 @default.
- W3115672273 cites W2029181309 @default.
- W3115672273 cites W2029298938 @default.
- W3115672273 cites W2029334733 @default.
- W3115672273 cites W2029471635 @default.
- W3115672273 cites W2030752961 @default.
- W3115672273 cites W2030975418 @default.
- W3115672273 cites W2031372687 @default.
- W3115672273 cites W2036205537 @default.
- W3115672273 cites W2037811574 @default.
- W3115672273 cites W2039026743 @default.
- W3115672273 cites W2043595610 @default.
- W3115672273 cites W2043789546 @default.
- W3115672273 cites W2045281397 @default.
- W3115672273 cites W2045401426 @default.
- W3115672273 cites W2046870314 @default.
- W3115672273 cites W2051554315 @default.
- W3115672273 cites W2052329951 @default.
- W3115672273 cites W2053604363 @default.
- W3115672273 cites W2056188558 @default.
- W3115672273 cites W2057303391 @default.
- W3115672273 cites W2058805663 @default.
- W3115672273 cites W2059600969 @default.
- W3115672273 cites W2059977407 @default.
- W3115672273 cites W2063614714 @default.
- W3115672273 cites W2067001382 @default.
- W3115672273 cites W2067724628 @default.
- W3115672273 cites W2068533217 @default.