Matches in SemOpenAlex for { <https://semopenalex.org/work/W3115695574> ?p ?o ?g. }
- W3115695574 endingPage "111427" @default.
- W3115695574 startingPage "111427" @default.
- W3115695574 abstract "Type 2 diabetes mellitus (T2DM) and osteoporosis are two major healthcare problems worldwide. T2DM is considered to be a risk factor for osteoporosis. Interestingly, several epidemiological studies suggest that bone abnormalities associated with diabetes may differ, at least in part, from those associated with senile or post-menopausal osteoporosis. The growing prevalence that patients with T2DM simultaneously suffer from osteoporosis, puts forward the importance to discuss the relationship between both diseases, as well as to investigate correlative agents to treat them. Emerging evidences demonstrate that neuropeptide galanin is involved in the pathogenesis of T2DM and osteoporosis. Galanin via activation of central GALR2 increases insulin sensitivity as well as bone density and mass in animal models. The disorder of galanin function plays major role in development of both diseases. Importantly, galanin signaling is indispensable for ΔFosB, an AP1 antagonist, to play the bone mass-accruing effects in the ventral hypothalamic neurons of diabetic models. This review summarizes our and other recent studies to provide a new insight into the multivariate relationship among galanin, T2DM and osteoporosis, highlighting the beneficial effect of galanin on the comorbid state of both diseases. These may help us better understanding the pathogenesis of osteoporosis and T2DM and provide useful clues for further inquiry if elevated galanin level may be taken as a biomarker for both conjoint diseases, and GALR2 agonist may be taken as a novel therapeutic strategy to treat both diseases concurrently." @default.
- W3115695574 created "2021-01-05" @default.
- W3115695574 creator A5004246385 @default.
- W3115695574 creator A5018426593 @default.
- W3115695574 creator A5021036942 @default.
- W3115695574 creator A5036287595 @default.
- W3115695574 creator A5070021070 @default.
- W3115695574 creator A5080883363 @default.
- W3115695574 creator A5083957735 @default.
- W3115695574 date "2021-03-01" @default.
- W3115695574 modified "2023-10-16" @default.
- W3115695574 title "A promising biomarker of elevated galanin level in hypothalamus for osteoporosis risk in type 2 diabetes mellitus" @default.
- W3115695574 cites W1485239067 @default.
- W3115695574 cites W1503238371 @default.
- W3115695574 cites W1857805568 @default.
- W3115695574 cites W1967471476 @default.
- W3115695574 cites W1968908922 @default.
- W3115695574 cites W1987812698 @default.
- W3115695574 cites W1992569054 @default.
- W3115695574 cites W2004438850 @default.
- W3115695574 cites W2011710545 @default.
- W3115695574 cites W2012157912 @default.
- W3115695574 cites W2014827571 @default.
- W3115695574 cites W2019190148 @default.
- W3115695574 cites W2020673982 @default.
- W3115695574 cites W2027934746 @default.
- W3115695574 cites W2028582009 @default.
- W3115695574 cites W2031525803 @default.
- W3115695574 cites W2055951468 @default.
- W3115695574 cites W2056635534 @default.
- W3115695574 cites W2057057091 @default.
- W3115695574 cites W2058980676 @default.
- W3115695574 cites W2061117796 @default.
- W3115695574 cites W2063436993 @default.
- W3115695574 cites W2068018993 @default.
- W3115695574 cites W2072973376 @default.
- W3115695574 cites W2076235891 @default.
- W3115695574 cites W2079405009 @default.
- W3115695574 cites W2079799868 @default.
- W3115695574 cites W2082103629 @default.
- W3115695574 cites W2083318175 @default.
- W3115695574 cites W2087368655 @default.
- W3115695574 cites W2088868089 @default.
- W3115695574 cites W2089480305 @default.
- W3115695574 cites W2090956763 @default.
- W3115695574 cites W2095711430 @default.
- W3115695574 cites W2103946487 @default.
- W3115695574 cites W2108437184 @default.
- W3115695574 cites W2123867809 @default.
- W3115695574 cites W2127176339 @default.
- W3115695574 cites W2128928747 @default.
- W3115695574 cites W2129523397 @default.
- W3115695574 cites W2135499396 @default.
- W3115695574 cites W2153047873 @default.
- W3115695574 cites W2155071292 @default.
- W3115695574 cites W2159169229 @default.
- W3115695574 cites W2165834855 @default.
- W3115695574 cites W2166806214 @default.
- W3115695574 cites W2174804130 @default.
- W3115695574 cites W2230725582 @default.
- W3115695574 cites W2233172544 @default.
- W3115695574 cites W2317064466 @default.
- W3115695574 cites W2322606461 @default.
- W3115695574 cites W2333865119 @default.
- W3115695574 cites W2482614679 @default.
- W3115695574 cites W2491792625 @default.
- W3115695574 cites W2510678964 @default.
- W3115695574 cites W2514532228 @default.
- W3115695574 cites W2517139131 @default.
- W3115695574 cites W2562268509 @default.
- W3115695574 cites W2563653893 @default.
- W3115695574 cites W2607421733 @default.
- W3115695574 cites W2613306172 @default.
- W3115695574 cites W2628137606 @default.
- W3115695574 cites W2747161160 @default.
- W3115695574 cites W2774081347 @default.
- W3115695574 cites W2783105249 @default.
- W3115695574 cites W2792215895 @default.
- W3115695574 cites W2794595575 @default.
- W3115695574 cites W2889373214 @default.
- W3115695574 cites W2898864113 @default.
- W3115695574 cites W2912474129 @default.
- W3115695574 cites W2913756725 @default.
- W3115695574 cites W2939944683 @default.
- W3115695574 cites W2961917464 @default.
- W3115695574 cites W2972869264 @default.
- W3115695574 cites W2975218358 @default.
- W3115695574 cites W2988787675 @default.
- W3115695574 cites W2992666626 @default.
- W3115695574 cites W3005100840 @default.
- W3115695574 cites W3025898755 @default.
- W3115695574 cites W3026050705 @default.
- W3115695574 cites W1890954964 @default.
- W3115695574 doi "https://doi.org/10.1016/j.mad.2020.111427" @default.
- W3115695574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33383074" @default.
- W3115695574 hasPublicationYear "2021" @default.
- W3115695574 type Work @default.
- W3115695574 sameAs 3115695574 @default.