Matches in SemOpenAlex for { <https://semopenalex.org/work/W3115804750> ?p ?o ?g. }
- W3115804750 abstract "SUMMARY Eukaryotic transfer RNAs can become selectively fragmented upon various stresses, generating tRNA-derived small RNA fragments. Such fragmentation has been reported to impact a small fraction of the tRNA pool and thus presumed to not directly impact translation. We report that oxidative stress can rapidly generate tyrosine tRNA GUA fragments in human cells—causing significant depletion of the precursor tRNA. Tyrosine tRNA GUA depletion impaired translation of growth and metabolic genes enriched in cognate tyrosine codons. Depletion of tyrosine tRNA GUA or its translationally regulated targets USP3 and SCD repressed proliferation—revealing a dedicated tRNA-regulated growth suppressive pathway for oxidative stress response. Tyrosine fragments are generated in a DIS3L2 exoribonuclease-dependent manner and inhibit hnRNPA1-mediated transcript destabilization. Moreover, tyrosine fragmentation is conserved in C. elegans . Thus, tRNA fragmentation can coordinately generate trans -acting small-RNAs and functionally deplete a tRNA. Our findings reveal the existence of an underlying adaptive codon-based regulatory response inherent to the genetic code." @default.
- W3115804750 created "2021-01-05" @default.
- W3115804750 creator A5000836338 @default.
- W3115804750 creator A5021388751 @default.
- W3115804750 creator A5021684735 @default.
- W3115804750 creator A5026244741 @default.
- W3115804750 creator A5034045594 @default.
- W3115804750 creator A5039592041 @default.
- W3115804750 creator A5049787538 @default.
- W3115804750 creator A5052376251 @default.
- W3115804750 creator A5065196031 @default.
- W3115804750 creator A5069514601 @default.
- W3115804750 creator A5082951092 @default.
- W3115804750 creator A5091610253 @default.
- W3115804750 date "2018-09-13" @default.
- W3115804750 modified "2023-10-11" @default.
- W3115804750 title "A stress-induced Tyrosine tRNA depletion response mediates codon-based translational repression and growth suppression" @default.
- W3115804750 cites W1554020011 @default.
- W3115804750 cites W1810708914 @default.
- W3115804750 cites W1832399013 @default.
- W3115804750 cites W1966973232 @default.
- W3115804750 cites W1983859619 @default.
- W3115804750 cites W1999609473 @default.
- W3115804750 cites W2000293147 @default.
- W3115804750 cites W2001394720 @default.
- W3115804750 cites W2005625535 @default.
- W3115804750 cites W2007013450 @default.
- W3115804750 cites W2008243630 @default.
- W3115804750 cites W2008255393 @default.
- W3115804750 cites W2013321787 @default.
- W3115804750 cites W2022862766 @default.
- W3115804750 cites W2026566929 @default.
- W3115804750 cites W2038226716 @default.
- W3115804750 cites W2040485185 @default.
- W3115804750 cites W2044117548 @default.
- W3115804750 cites W2052418918 @default.
- W3115804750 cites W2053003053 @default.
- W3115804750 cites W2053998703 @default.
- W3115804750 cites W2055639102 @default.
- W3115804750 cites W2064236156 @default.
- W3115804750 cites W2065458612 @default.
- W3115804750 cites W2068694787 @default.
- W3115804750 cites W2072499238 @default.
- W3115804750 cites W2073863519 @default.
- W3115804750 cites W2079517684 @default.
- W3115804750 cites W2087463572 @default.
- W3115804750 cites W2092221199 @default.
- W3115804750 cites W2097654784 @default.
- W3115804750 cites W2098131661 @default.
- W3115804750 cites W210302837 @default.
- W3115804750 cites W2104806799 @default.
- W3115804750 cites W2106039274 @default.
- W3115804750 cites W2107804881 @default.
- W3115804750 cites W2108053190 @default.
- W3115804750 cites W2108138064 @default.
- W3115804750 cites W2109140791 @default.
- W3115804750 cites W2112243735 @default.
- W3115804750 cites W2113710155 @default.
- W3115804750 cites W2114147818 @default.
- W3115804750 cites W2114694498 @default.
- W3115804750 cites W2114982790 @default.
- W3115804750 cites W2115768394 @default.
- W3115804750 cites W2116831267 @default.
- W3115804750 cites W2119722433 @default.
- W3115804750 cites W2126780661 @default.
- W3115804750 cites W2137969903 @default.
- W3115804750 cites W2139657437 @default.
- W3115804750 cites W2141707748 @default.
- W3115804750 cites W2145067337 @default.
- W3115804750 cites W2145412955 @default.
- W3115804750 cites W2148224382 @default.
- W3115804750 cites W2152165298 @default.
- W3115804750 cites W2154608547 @default.
- W3115804750 cites W2155765704 @default.
- W3115804750 cites W2158741313 @default.
- W3115804750 cites W2164760302 @default.
- W3115804750 cites W2170539205 @default.
- W3115804750 cites W2172249877 @default.
- W3115804750 cites W2201382378 @default.
- W3115804750 cites W2210080033 @default.
- W3115804750 cites W2259283565 @default.
- W3115804750 cites W2319914265 @default.
- W3115804750 cites W2418276263 @default.
- W3115804750 cites W2516993644 @default.
- W3115804750 cites W2517479181 @default.
- W3115804750 cites W2537007468 @default.
- W3115804750 cites W2554225141 @default.
- W3115804750 cites W2604808360 @default.
- W3115804750 cites W2621281388 @default.
- W3115804750 cites W2742248038 @default.
- W3115804750 cites W2742512275 @default.
- W3115804750 cites W2742715352 @default.
- W3115804750 cites W2751076435 @default.
- W3115804750 cites W2769036773 @default.
- W3115804750 cites W2795813366 @default.
- W3115804750 cites W2804648738 @default.
- W3115804750 cites W2806435205 @default.
- W3115804750 cites W2810645965 @default.
- W3115804750 cites W2890219238 @default.
- W3115804750 cites W2911351489 @default.