FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3115869981> ?p ?o ?g. }

• W3115869981 endingPage "108424" @default.
• W3115869981 startingPage "108424" @default.
• W3115869981 abstract "Chronic oxidative stress and immune dysregulation are key mechanisms involved in the pathogenesis of most retinal degenerative diseases, including age-related macular degeneration. The Ccl2−/−/Cx3cr1−/−/Crb1rd8/rd8 mouse model develops a progressive degeneration phenotype, with photoreceptor atrophy, drusen-like lesions or pigment alterations at an early age; however, the role of oxidative stress and immune function in the pathogenesis of the model is poorly understood. We performed a comprehensive characterization of the Ccl2−/−/Cx3cr1−/−/Crb1rd8/rd8 mouse to evaluate how these pathways influence pathogenesis. We generated a Ccl2−/−/Cx3cr1−/− double-knockout (DKO) mouse on a C57BL/6N background (with the rd8 mutation of the Crb1 gene), assessed its retina status and function during 9 months in both in vivo and post-mortem analysis, and performed a comprehensive transcriptomic analysis. DKOrd8 mice presented focal retinal lesions with increased infiltration of microglia and involvement of Müller cells. Lesions progressed to thinning of the photoreceptor nuclear layer, causing a loss in retinal function. Transcriptomics analysis revealed major differential expression of genes involved in oxidative stress and neuronal function, in particular genes related to the mitochondrial electron transport chain and antioxidant cellular response. Our results suggest that alterations in chemokine signaling combined with the rd8 mutation in Ccl2−/−/Cx3cr1−/−/Crb1rd8/rd8 mice involve early changes in several pathways associated with age-related macular degeneration, highlighting the relevance of these processes in the pathological retinal degeneration in the DKOrd8 model." @default.
• W3115869981 created "2021-01-05" @default.
• W3115869981 creator A5024519719 @default.
• W3115869981 creator A5040184354 @default.
• W3115869981 creator A5046986650 @default.
• W3115869981 creator A5067715824 @default.
• W3115869981 creator A5069170813 @default.
• W3115869981 creator A5069734048 @default.
• W3115869981 creator A5074238289 @default.
• W3115869981 date "2021-02-01" @default.
• W3115869981 modified "2023-10-18" @default.
• W3115869981 title "Transcriptomics analysis of Ccl2/Cx3cr1/Crb1rd8 deficient mice provides new insights into the pathophysiology of progressive retinal degeneration" @default.
• W3115869981 cites W1599123965 @default.
• W3115869981 cites W1938428766 @default.
• W3115869981 cites W1955438350 @default.
• W3115869981 cites W1969157499 @default.
• W3115869981 cites W1987960089 @default.
• W3115869981 cites W1996703105 @default.
• W3115869981 cites W2005659566 @default.
• W3115869981 cites W2017391147 @default.
• W3115869981 cites W2019369653 @default.
• W3115869981 cites W2023333115 @default.
• W3115869981 cites W2029990936 @default.
• W3115869981 cites W2030350058 @default.
• W3115869981 cites W2036704550 @default.
• W3115869981 cites W2039676145 @default.
• W3115869981 cites W2040385741 @default.
• W3115869981 cites W2043975730 @default.
• W3115869981 cites W2087711766 @default.
• W3115869981 cites W2090921808 @default.
• W3115869981 cites W2092996093 @default.
• W3115869981 cites W2102267006 @default.
• W3115869981 cites W2104301336 @default.
• W3115869981 cites W2122311980 @default.
• W3115869981 cites W2126360899 @default.
• W3115869981 cites W2136377226 @default.
• W3115869981 cites W2136542582 @default.
• W3115869981 cites W2150132566 @default.
• W3115869981 cites W2150724604 @default.
• W3115869981 cites W2161057248 @default.
• W3115869981 cites W2168558228 @default.
• W3115869981 cites W2168995138 @default.
• W3115869981 cites W2172287880 @default.
• W3115869981 cites W2175933822 @default.
• W3115869981 cites W2233221674 @default.
• W3115869981 cites W238288757 @default.
• W3115869981 cites W2734721636 @default.
• W3115869981 cites W2752834350 @default.
• W3115869981 cites W2759633738 @default.
• W3115869981 cites W2785783433 @default.
• W3115869981 cites W2897831960 @default.
• W3115869981 cites W2899825987 @default.
• W3115869981 cites W2914762802 @default.
• W3115869981 cites W2944001926 @default.
• W3115869981 cites W4247214019 @default.
• W3115869981 doi "https://doi.org/10.1016/j.exer.2020.108424" @default.
• W3115869981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33373623" @default.
• W3115869981 hasPublicationYear "2021" @default.
• W3115869981 type Work @default.
• W3115869981 sameAs 3115869981 @default.
• W3115869981 citedByCount "9" @default.
• W3115869981 countsByYear W31158699812021 @default.
• W3115869981 countsByYear W31158699812022 @default.
• W3115869981 countsByYear W31158699812023 @default.
• W3115869981 crossrefType "journal-article" @default.
• W3115869981 hasAuthorship W3115869981A5024519719 @default.
• W3115869981 hasAuthorship W3115869981A5040184354 @default.
• W3115869981 hasAuthorship W3115869981A5046986650 @default.
• W3115869981 hasAuthorship W3115869981A5067715824 @default.
• W3115869981 hasAuthorship W3115869981A5069170813 @default.
• W3115869981 hasAuthorship W3115869981A5069734048 @default.
• W3115869981 hasAuthorship W3115869981A5074238289 @default.
• W3115869981 hasConcept C104317684 @default.
• W3115869981 hasConcept C12823836 @default.
• W3115869981 hasConcept C13373296 @default.
• W3115869981 hasConcept C134018914 @default.
• W3115869981 hasConcept C142724271 @default.
• W3115869981 hasConcept C150194340 @default.
• W3115869981 hasConcept C162317418 @default.
• W3115869981 hasConcept C169760540 @default.
• W3115869981 hasConcept C186198217 @default.
• W3115869981 hasConcept C203014093 @default.
• W3115869981 hasConcept C2776151105 @default.
• W3115869981 hasConcept C2776914184 @default.
• W3115869981 hasConcept C2777093970 @default.
• W3115869981 hasConcept C2778024200 @default.
• W3115869981 hasConcept C2779093074 @default.
• W3115869981 hasConcept C2780827179 @default.
• W3115869981 hasConcept C2780942790 @default.
• W3115869981 hasConcept C2781040256 @default.
• W3115869981 hasConcept C31179232 @default.
• W3115869981 hasConcept C54355233 @default.
• W3115869981 hasConcept C55493867 @default.
• W3115869981 hasConcept C71924100 @default.
• W3115869981 hasConcept C86803240 @default.
• W3115869981 hasConcept C95444343 @default.
• W3115869981 hasConceptScore W3115869981C104317684 @default.
• W3115869981 hasConceptScore W3115869981C12823836 @default.

• next