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- W3115948567 abstract "Metabolism is a critical determinant of immune cell functionality. Immunometabolism, by definition, is a multidisciplinary area of immunology research that integrates the knowledge of energy transduction mechanisms and biochemical pathways. An important concept in the field is metabolic switch, a transition of immune cells upon activation to preferential utilization of select catabolic pathways for their energy needs. Mitochondria are not inert in this process and contribute to the metabolic adaptation by different mechanisms which include increasing ATP production to match dynamic bioenergetic demands and serving as a signaling platform. The latter involves generation of reactive oxygen species (ROS), one of the most intensively studied mitochondrial processes. While the role of mitochondrial ROS in the context of oxidative stress is well established, ROS signaling in immunity is an emerging and quickly changing field. In this review, we discuss ROS signaling and immunometabolism concepts from the standpoint of bioenergetics. We also provide a critical insight into the methodology for ROS assessment, outlining current challenges in the field. Finally, based on our analysis of the literature data, we hypothesize that regulatory ROS production, as opposed to oxidative stress, is controlled by mitochondrial biogenesis rather than metabolic switches." @default.
- W3115948567 created "2021-01-05" @default.
- W3115948567 creator A5024617546 @default.
- W3115948567 creator A5033439967 @default.
- W3115948567 creator A5042926381 @default.
- W3115948567 creator A5087246241 @default.
- W3115948567 date "2020-12-01" @default.
- W3115948567 modified "2023-10-10" @default.
- W3115948567 title "Metabolic ROS Signaling: To Immunity and Beyond" @default.
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