FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3115991602> ?p ?o ?g. }

• W3115991602 endingPage "61" @default.
• W3115991602 startingPage "61" @default.
• W3115991602 abstract "I-Motif is a tetrameric cytosine-rich DNA structure with hemi-protonated cytosine: cytosine base pairs. Recent evidence showed that i-motif structures in human cells play regulatory roles in the genome. Therefore, characterization of novel i-motifs and investigation of their functional implication are urgently needed for comprehensive understanding of their roles in gene regulation. However, considering the complications of experimental investigation of i-motifs and the large number of putative i-motifs in the genome, development of an in silico tool for the characterization of i-motifs in the high throughput scale is necessary. We developed a novel computation method, MD-TSPC4, to predict the thermal stability of i-motifs based on molecular modeling and molecular dynamic simulation. By assuming that the flexibility of loops in i-motifs correlated with thermal stability within certain temperature ranges, we evaluated the correlation between the root mean square deviations (RMSDs) of model structures and the thermal stability as the experimentally obtained melting temperature (Tm). Based on this correlation, we propose an equation for Tm prediction from RMSD. We expect this method can be useful for estimating the overall structure and stability of putative i-motifs in the genome, which can be a starting point of further structural and functional studies of i-motifs." @default.
• W3115991602 created "2021-01-05" @default.
• W3115991602 creator A5001672348 @default.
• W3115991602 creator A5053348830 @default.
• W3115991602 creator A5063595248 @default.
• W3115991602 date "2020-12-23" @default.
• W3115991602 modified "2023-10-16" @default.
• W3115991602 title "MD-TSPC4: Computational Method for Predicting the Thermal Stability of I-Motif" @default.
• W3115991602 cites W1549357029 @default.
• W3115991602 cites W1972485143 @default.
• W3115991602 cites W1975580333 @default.
• W3115991602 cites W1977958121 @default.
• W3115991602 cites W1987600945 @default.
• W3115991602 cites W2013490254 @default.
• W3115991602 cites W2020378172 @default.
• W3115991602 cites W2025056250 @default.
• W3115991602 cites W2027490761 @default.
• W3115991602 cites W2041834854 @default.
• W3115991602 cites W2043748834 @default.
• W3115991602 cites W2045840287 @default.
• W3115991602 cites W2062451058 @default.
• W3115991602 cites W2071115595 @default.
• W3115991602 cites W2073722866 @default.
• W3115991602 cites W2074139680 @default.
• W3115991602 cites W2074613554 @default.
• W3115991602 cites W2080311192 @default.
• W3115991602 cites W2092424765 @default.
• W3115991602 cites W2097521277 @default.
• W3115991602 cites W2106140689 @default.
• W3115991602 cites W2124026197 @default.
• W3115991602 cites W2128345861 @default.
• W3115991602 cites W2130652515 @default.
• W3115991602 cites W2132629607 @default.
• W3115991602 cites W2144864324 @default.
• W3115991602 cites W2162908318 @default.
• W3115991602 cites W2169745877 @default.
• W3115991602 cites W2204959575 @default.
• W3115991602 cites W2269684016 @default.
• W3115991602 cites W2312536974 @default.
• W3115991602 cites W2332712348 @default.
• W3115991602 cites W2472497945 @default.
• W3115991602 cites W2489091245 @default.
• W3115991602 cites W2621220151 @default.
• W3115991602 cites W2760768430 @default.
• W3115991602 cites W2766679495 @default.
• W3115991602 cites W2770476546 @default.
• W3115991602 cites W2791537518 @default.
• W3115991602 cites W2800768216 @default.
• W3115991602 cites W2886466753 @default.
• W3115991602 cites W2893723058 @default.
• W3115991602 cites W2904555329 @default.
• W3115991602 cites W2912083700 @default.
• W3115991602 cites W2923522997 @default.
• W3115991602 cites W2945411637 @default.
• W3115991602 cites W2980898692 @default.
• W3115991602 cites W2984490818 @default.
• W3115991602 cites W3003427449 @default.
• W3115991602 cites W3003646737 @default.
• W3115991602 cites W4253682273 @default.
• W3115991602 doi "https://doi.org/10.3390/ijms22010061" @default.
• W3115991602 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7793491" @default.
• W3115991602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33374624" @default.
• W3115991602 hasPublicationYear "2020" @default.
• W3115991602 type Work @default.
• W3115991602 sameAs 3115991602 @default.
• W3115991602 citedByCount "1" @default.
• W3115991602 countsByYear W31159916022023 @default.
• W3115991602 crossrefType "journal-article" @default.
• W3115991602 hasAuthorship W3115991602A5001672348 @default.
• W3115991602 hasAuthorship W3115991602A5053348830 @default.
• W3115991602 hasAuthorship W3115991602A5063595248 @default.
• W3115991602 hasBestOaLocation W31159916021 @default.
• W3115991602 hasConcept C104317684 @default.
• W3115991602 hasConcept C121332964 @default.
• W3115991602 hasConcept C132677234 @default.
• W3115991602 hasConcept C141231307 @default.
• W3115991602 hasConcept C147597530 @default.
• W3115991602 hasConcept C178790620 @default.
• W3115991602 hasConcept C185592680 @default.
• W3115991602 hasConcept C24890656 @default.
• W3115991602 hasConcept C2775905019 @default.
• W3115991602 hasConcept C2776023528 @default.
• W3115991602 hasConcept C32276052 @default.
• W3115991602 hasConcept C54355233 @default.
• W3115991602 hasConcept C55493867 @default.
• W3115991602 hasConcept C59061564 @default.
• W3115991602 hasConcept C59593255 @default.
• W3115991602 hasConcept C70721500 @default.
• W3115991602 hasConcept C86803240 @default.
• W3115991602 hasConceptScore W3115991602C104317684 @default.
• W3115991602 hasConceptScore W3115991602C121332964 @default.
• W3115991602 hasConceptScore W3115991602C132677234 @default.
• W3115991602 hasConceptScore W3115991602C141231307 @default.
• W3115991602 hasConceptScore W3115991602C147597530 @default.
• W3115991602 hasConceptScore W3115991602C178790620 @default.
• W3115991602 hasConceptScore W3115991602C185592680 @default.
• W3115991602 hasConceptScore W3115991602C24890656 @default.
• W3115991602 hasConceptScore W3115991602C2775905019 @default.

• next