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• W3116060147 abstract "Transcription-induced chimeric RNAs are an emerging area of research into molecular signatures for disease biomarker and therapeutic target development. Despite their importance, little is known for chimeric RNAs-relevant roles and the underlying mechanisms for cancer pathogenesis and progression. Here we describe a unique ASTN2-PAPPAantisense chimeric RNA (A-PaschiRNA) that could be the first reported chimeric RNA derived from the splicing of exons and intron antisense of two neighboring genes, respectively. Aberrant A-PaschiRNA level in ESCC tissues was associated with tumor progression and patients’ outcome. In vitro and in vivo studies demonstrated that A-PaschiRNA aggravated ESCC metastasis and enhanced stemness through modulating OCT4. Mechanistic studies demonstrated that ERK5-mediated non-canonical PAF1 activity was required for A-PaschiRNA-induced cancer malignancy. The study defined an undocumented function of chimeric RNAs in aggravating cancer stemness and metastasis." @default.
• W3116060147 created "2021-01-05" @default.
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• W3116060147 date "2021-03-01" @default.
• W3116060147 modified "2023-10-18" @default.
• W3116060147 title "Chimeric RNA ASTN2-PAPPAas aggravates tumor progression and metastasis in human esophageal cancer" @default.
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• W3116060147 doi "https://doi.org/10.1016/j.canlet.2020.10.052" @default.
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