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- W3116066734 abstract "There is evidence that ATM mutated in ataxia-telangiectasia (A-T) plays a key role in protecting against mitochondrial dysfunction, the mechanism for which remains unresolved. We demonstrate here that ATM-deficient cells are exquisitely sensitive to nutrient deprivation, which can be explained by defective cross talk between the endoplasmic reticulum (ER) and the mitochondrion. Tethering between these two organelles in response to stress was reduced in cells lacking ATM, and consistent with this, Ca2+ release and transfer between ER and mitochondria was reduced dramatically when compared with control cells. The impact of this on mitochondrial function was evident from an increase in oxygen consumption rates and a defect in mitophagy in ATM-deficient cells. Our findings reveal that ER-mitochondrial connectivity through IP3R1-GRP75-VDAC1, to maintain Ca2+ homeostasis, as well as an abnormality in mitochondrial fusion defective in response to nutrient stress, can account for at least part of the mitochondrial dysfunction observed in A-T cells." @default.
- W3116066734 created "2021-01-05" @default.
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- W3116066734 date "2021-01-01" @default.
- W3116066734 modified "2023-10-13" @default.
- W3116066734 title "Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia" @default.
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- W3116066734 doi "https://doi.org/10.1016/j.isci.2020.101972" @default.
- W3116066734 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7788243" @default.
- W3116066734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33437944" @default.
- W3116066734 hasPublicationYear "2021" @default.
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