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- W3116295251 abstract "New peptide dendrimer with Lys-2Arg repeating units was recently studied experimentally by NMR (RSC Advances, 2019, 9, 18018) and tested as gene carrier successfully (Int. J. Mol. Sci., 2020, 21, 3138). The unusual slowing down of the orientational mobility of 2Arg spacers in this dendrimer was revealed. It has been suggested that this unexpected behavior is caused by the Arg-Arg pairing effect in water, which leads to entanglements between dendrimer branches. In this paper, we determine the reason for this slowing down using atomistic molecular dynamics simulation of this dendrimer. We present that the structural properties of Lys-2Arg dendrimer are close to those of the Lys-2Lys dendrimer at all temperatures (Polymers, 2020, 12, 1657). However, the orientational mobility of the H-H vector in CH2-N groups of 2Arg spacers in Lys-2Arg dendrimer is significantly slower than the mobility of the same vector in the Lys-2Lys dendrimer. This result is in agreement with the recent NMR experiments for the same systems. We revealed that this difference is not due to the arginine-arginine pairing, but is due to the semiflexibility effect associated with the different contour length from CH2-N group to the end of the side arginine or lysine segment in spacers." @default.
- W3116295251 created "2021-01-05" @default.
- W3116295251 creator A5001580715 @default.
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- W3116295251 creator A5017951718 @default.
- W3116295251 creator A5023630243 @default.
- W3116295251 creator A5025077067 @default.
- W3116295251 date "2020-12-21" @default.
- W3116295251 modified "2023-09-26" @default.
- W3116295251 title "Why the Orientational Mobility in Arginine and Lysine Spacers of Peptide Dendrimers Designed for Gene Delivery Is Different?" @default.
- W3116295251 cites W1031578623 @default.
- W3116295251 cites W1485176391 @default.
- W3116295251 cites W1542936893 @default.
- W3116295251 cites W1865646704 @default.
- W3116295251 cites W1963741796 @default.
- W3116295251 cites W1964579868 @default.
- W3116295251 cites W1967820830 @default.
- W3116295251 cites W1969835583 @default.
- W3116295251 cites W1970755977 @default.
- W3116295251 cites W1973718137 @default.
- W3116295251 cites W1986004569 @default.
- W3116295251 cites W1986647135 @default.
- W3116295251 cites W1987327282 @default.
- W3116295251 cites W1987534351 @default.
- W3116295251 cites W1988680128 @default.
- W3116295251 cites W1990434569 @default.
- W3116295251 cites W1992620470 @default.
- W3116295251 cites W1993561446 @default.
- W3116295251 cites W1995323554 @default.
- W3116295251 cites W1998019495 @default.
- W3116295251 cites W2002398055 @default.
- W3116295251 cites W2008107018 @default.
- W3116295251 cites W2009500363 @default.
- W3116295251 cites W2013885842 @default.
- W3116295251 cites W2014509855 @default.
- W3116295251 cites W2021294436 @default.
- W3116295251 cites W2024400771 @default.
- W3116295251 cites W2024433496 @default.
- W3116295251 cites W2029566389 @default.
- W3116295251 cites W2032474521 @default.
- W3116295251 cites W2039551908 @default.
- W3116295251 cites W2043340061 @default.
- W3116295251 cites W2050528759 @default.
- W3116295251 cites W2051638855 @default.
- W3116295251 cites W2057141118 @default.
- W3116295251 cites W2057581357 @default.
- W3116295251 cites W2059397448 @default.
- W3116295251 cites W2064554825 @default.
- W3116295251 cites W2067105792 @default.
- W3116295251 cites W2071506921 @default.
- W3116295251 cites W2072373440 @default.
- W3116295251 cites W2072793559 @default.
- W3116295251 cites W2072959420 @default.
- W3116295251 cites W2074161384 @default.
- W3116295251 cites W2074475742 @default.
- W3116295251 cites W2077064239 @default.
- W3116295251 cites W2079990341 @default.
- W3116295251 cites W2080823739 @default.
- W3116295251 cites W2081693079 @default.
- W3116295251 cites W2083242442 @default.
- W3116295251 cites W2085516892 @default.
- W3116295251 cites W2086779207 @default.
- W3116295251 cites W2091329712 @default.
- W3116295251 cites W2092278908 @default.
- W3116295251 cites W2123542701 @default.
- W3116295251 cites W2124096526 @default.
- W3116295251 cites W2149076882 @default.
- W3116295251 cites W2153234034 @default.
- W3116295251 cites W2161605421 @default.
- W3116295251 cites W2162826264 @default.
- W3116295251 cites W2170636019 @default.
- W3116295251 cites W2268686944 @default.
- W3116295251 cites W2277064120 @default.
- W3116295251 cites W2324760688 @default.
- W3116295251 cites W2467743933 @default.
- W3116295251 cites W2508542236 @default.
- W3116295251 cites W2531102738 @default.
- W3116295251 cites W2569533972 @default.
- W3116295251 cites W2611053438 @default.
- W3116295251 cites W2731862792 @default.
- W3116295251 cites W2735146966 @default.
- W3116295251 cites W2736652857 @default.
- W3116295251 cites W2743015141 @default.
- W3116295251 cites W2757739516 @default.
- W3116295251 cites W2760758412 @default.
- W3116295251 cites W2774607908 @default.
- W3116295251 cites W2778935067 @default.
- W3116295251 cites W2797382267 @default.
- W3116295251 cites W2802534770 @default.
- W3116295251 cites W2805662025 @default.
- W3116295251 cites W2896513295 @default.
- W3116295251 cites W2904909276 @default.
- W3116295251 cites W2937885343 @default.
- W3116295251 cites W2945997494 @default.
- W3116295251 cites W2947767633 @default.
- W3116295251 cites W2948938947 @default.
- W3116295251 cites W2953713921 @default.