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• W3116317059 abstract "Industrial-scale synthesis of eldecalcitol is described. AA highly diastereoselective epoxidation of p-methoxybenzyl (PMB) protected dienol at room temperature provides the key epoxide intermediate with a secondary hydroxyl group, which is alkylated with a triflate to set up all of the subunits at the C-1, C-2, and C-3 positions of the A-ring fragment. Selective protecting group manipulation followed by palladium-catalyzed cyclization then provides the A-ring synthon. The C/D-ring fragment is obtained by (1) direct C-H hydroxylation of Grundman’s ketone using in situ prepared trifluoropropanone dioxirane and (2) protection. Finally, the coupling of the A-ring with the C/D-ring fragment, global deprotection, and recrystallization provide the highly crystalline eldecalcitol." @default.
• W3116317059 created "2021-01-05" @default.
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• W3116317059 date "2020-12-17" @default.
• W3116317059 modified "2023-10-14" @default.
• W3116317059 title "Large-Scale Synthesis of Eldecalcitol" @default.
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• W3116317059 doi "https://doi.org/10.1021/acs.oprd.0c00436" @default.
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