FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3116365794> ?p ?o ?g. }

• W3116365794 abstract "Neuroprotection strategies after cardiac arrest (CA)/cardiopulmonary resuscitation (CPR) remain key areas of basic and clinical research. This study was designed to investigate the neuroprotective effects of dexmedetomidine following resuscitation and potential mechanisms.Anesthetized rats underwent 6-min asphyxia-based cardiac arrest and resuscitation, after which the experimental group received a single intravenous dose of dexmedetomidine (25 μg/kg). Neurological outcomes and ataxia were assessed after the return of spontaneous circulation. The serum levels and brain expression of inflammation markers was examined, and apoptotic cells were quantified by TUNEL staining.Neuroprotection was enhanced by dexmedetomidine post-conditioning after the return of spontaneous circulation. This enhancement was characterized by the promotion of neurological function scores and coordination. In addition, dexmedetomidine post-conditioning attenuated the serum levels of the pro-inflammatory cytokine tumor necrosis factor (TNF)-α at 2 h, as well as interleukin IL-1β at 2, 24, and 48 h. TUNEL staining showed that the number of apoptotic cells in the dexmedetomidine post-conditioning group was significantly reduced compared with the control group. Further western blot analysis indicated that dexmedetomidine markedly reduced the levels of caspase-3 and nuclear factor-kappa B (NF-κB) in the brain.Dexmedetomidine post-conditioning had a neuroprotective effect against cerebral injury following asphyxia-induced cardiac arrest. The mechanism was associated with the downregulation of apoptosis and neuroinflammation." @default.
• W3116365794 created "2021-01-05" @default.
• W3116365794 creator A5014193844 @default.
• W3116365794 creator A5022236835 @default.
• W3116365794 creator A5060840778 @default.
• W3116365794 creator A5083057726 @default.
• W3116365794 date "2021-06-28" @default.
• W3116365794 modified "2023-10-10" @default.
• W3116365794 title "Dexmedetomidine post-conditioning attenuates cerebral ischemia following asphyxia cardiac arrest through down-regulation of apoptosis and neuroinflammation in rats" @default.
• W3116365794 cites W1540436551 @default.
• W3116365794 cites W1633660980 @default.
• W3116365794 cites W1729182783 @default.
• W3116365794 cites W1797578063 @default.
• W3116365794 cites W1982794774 @default.
• W3116365794 cites W1995841847 @default.
• W3116365794 cites W2001190649 @default.
• W3116365794 cites W2004349171 @default.
• W3116365794 cites W2008200041 @default.
• W3116365794 cites W2008757142 @default.
• W3116365794 cites W2009067373 @default.
• W3116365794 cites W2009822336 @default.
• W3116365794 cites W2025829561 @default.
• W3116365794 cites W2028164609 @default.
• W3116365794 cites W2048787922 @default.
• W3116365794 cites W2131607023 @default.
• W3116365794 cites W2133496985 @default.
• W3116365794 cites W2138096868 @default.
• W3116365794 cites W2185074100 @default.
• W3116365794 cites W2229960474 @default.
• W3116365794 cites W2300776102 @default.
• W3116365794 cites W2345800611 @default.
• W3116365794 cites W2359355557 @default.
• W3116365794 cites W2604303367 @default.
• W3116365794 cites W2611879622 @default.
• W3116365794 cites W2734525009 @default.
• W3116365794 cites W2767657316 @default.
• W3116365794 cites W2789018622 @default.
• W3116365794 cites W2804147644 @default.
• W3116365794 cites W2808877002 @default.
• W3116365794 cites W2891307472 @default.
• W3116365794 cites W2899502873 @default.
• W3116365794 cites W2901611055 @default.
• W3116365794 cites W2912674826 @default.
• W3116365794 cites W2914543842 @default.
• W3116365794 cites W2916655308 @default.
• W3116365794 cites W2922489710 @default.
• W3116365794 cites W2931270070 @default.
• W3116365794 cites W2942017172 @default.
• W3116365794 cites W2949446892 @default.
• W3116365794 cites W2951048045 @default.
• W3116365794 cites W2953469387 @default.
• W3116365794 cites W2955979069 @default.
• W3116365794 cites W3040577665 @default.
• W3116365794 doi "https://doi.org/10.1186/s12871-021-01394-7" @default.
• W3116365794 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8236741" @default.
• W3116365794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34182937" @default.
• W3116365794 hasPublicationYear "2021" @default.
• W3116365794 type Work @default.
• W3116365794 sameAs 3116365794 @default.
• W3116365794 citedByCount "4" @default.
• W3116365794 countsByYear W31163657942021 @default.
• W3116365794 countsByYear W31163657942023 @default.
• W3116365794 crossrefType "journal-article" @default.
• W3116365794 hasAuthorship W3116365794A5014193844 @default.
• W3116365794 hasAuthorship W3116365794A5022236835 @default.
• W3116365794 hasAuthorship W3116365794A5060840778 @default.
• W3116365794 hasAuthorship W3116365794A5083057726 @default.
• W3116365794 hasBestOaLocation W31163657941 @default.
• W3116365794 hasConcept C126322002 @default.
• W3116365794 hasConcept C196795494 @default.
• W3116365794 hasConcept C204232928 @default.
• W3116365794 hasConcept C25498285 @default.
• W3116365794 hasConcept C2776814716 @default.
• W3116365794 hasConcept C2776914184 @default.
• W3116365794 hasConcept C2777055891 @default.
• W3116365794 hasConcept C2778165595 @default.
• W3116365794 hasConcept C2778619729 @default.
• W3116365794 hasConcept C2781302539 @default.
• W3116365794 hasConcept C42219234 @default.
• W3116365794 hasConcept C71924100 @default.
• W3116365794 hasConcept C87753298 @default.
• W3116365794 hasConcept C98274493 @default.
• W3116365794 hasConceptScore W3116365794C126322002 @default.
• W3116365794 hasConceptScore W3116365794C196795494 @default.
• W3116365794 hasConceptScore W3116365794C204232928 @default.
• W3116365794 hasConceptScore W3116365794C25498285 @default.
• W3116365794 hasConceptScore W3116365794C2776814716 @default.
• W3116365794 hasConceptScore W3116365794C2776914184 @default.
• W3116365794 hasConceptScore W3116365794C2777055891 @default.
• W3116365794 hasConceptScore W3116365794C2778165595 @default.
• W3116365794 hasConceptScore W3116365794C2778619729 @default.
• W3116365794 hasConceptScore W3116365794C2781302539 @default.
• W3116365794 hasConceptScore W3116365794C42219234 @default.
• W3116365794 hasConceptScore W3116365794C71924100 @default.
• W3116365794 hasConceptScore W3116365794C87753298 @default.
• W3116365794 hasConceptScore W3116365794C98274493 @default.
• W3116365794 hasFunder F4320321001 @default.
• W3116365794 hasIssue "1" @default.
• W3116365794 hasLocation W31163657941 @default.
• W3116365794 hasLocation W31163657942 @default.

• next