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- W3116367124 abstract "Translational control is essential in response to stress. We investigated the translational programmes launched by the fission yeast Schizosaccharomyces pombe upon five environmental stresses. We also explored the contribution of defence pathways to these programmes: The Integrated Stress Response (ISR), which regulates translation initiation, and the stress-response MAPK pathway. We performed ribosome profiling of cells subjected to each stress, in wild type cells and in cells with the defence pathways inactivated. The transcription factor Fil1, a functional homologue of the yeast Gcn4 and the mammalian Atf4 proteins, was translationally upregulated and required for the response to most stresses. Moreover, many mRNAs encoding proteins required for ribosome biogenesis were translationally downregulated. Thus, several stresses trigger a universal translational response, including reduced ribosome production and a Fil1-mediated transcriptional programme. Surprisingly, ribosomes stalled on tryptophan codons upon oxidative stress, likely due to a decrease in charged tRNA-Tryptophan. Stalling caused ribosome accumulation upstream of tryptophan codons (ribosome queuing/collisions), demonstrating that stalled ribosomes affect translation elongation by other ribosomes. Consistently, tryptophan codon stalling led to reduced translation elongation and contributed to the ISR-mediated inhibition of initiation. We show that different stresses elicit common and specific translational responses, revealing a novel role in Tryptophan-tRNA availability." @default.
- W3116367124 created "2021-01-05" @default.
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- W3116367124 date "2020-12-11" @default.
- W3116367124 modified "2023-10-14" @default.
- W3116367124 title "Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast" @default.
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- W3116367124 doi "https://doi.org/10.1093/nar/gkaa1180" @default.
- W3116367124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7797079" @default.
- W3116367124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33313903" @default.
- W3116367124 hasPublicationYear "2020" @default.
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