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- W3116499919 abstract "Zinc is an essential element with an important role in stimulating the osteogenesis and mineralization and suppressing osteoclast differentiation. In this study, new bioactive ZnCl 2 -doped sol-gel materials were designed to be applied as coatings onto titanium. The biomaterials were physicochemically characterized and the cellular responses evaluated in vitro using MC3T3-E1 osteoblasts and RAW264.7 macrophages. The effect of Zn on the adsorption of human serum proteins onto the material surface was evaluated through nLC-MS/MS. The incorporation of Zn did not affect the crosslinking of the sol-gel network. A controlled Zn 2+ release was obtained, reaching values below 10 ppm after 21 days. The materials were no cytotoxic and lead to increased gene expression of ALP, TGF-β, and RUNX2 in the osteoblasts. In macrophages, an increase of IL-1β, TGF-β, and IL-4 gene expression was accompanied by a reduced TNF-α liberation. Proteomic results showed changes in the adsorption patterns of proteins associated with immunological, coagulative, and regenerative functions, in a Zn dose-dependent manner. The variations in protein adsorption might lead to the downregulation of the NF-κB pathway, thus explain the observed biological effects of Zn incorporation into biomaterials. Overall, these coatings demonstrated their potential to promote bone tissue regeneration. • New bioactive Zn-doped sol-gel coatings were developed and characterized. • Zn-doped coatings could improve bone regeneration in a Zn dose-dependent manner. • The coatings with Zn showed anti-inflammatory effects. • A correlation between protein adsorption and cellular response were established. • A better understanding of Zn-doped biomaterials-tissue interactions was achieved." @default.
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- W3116499919 date "2021-02-01" @default.
- W3116499919 modified "2023-10-18" @default.
- W3116499919 title "Bioactive zinc-doped sol-gel coating modulates protein adsorption patterns and in vitro cell responses" @default.
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- W3116499919 doi "https://doi.org/10.1016/j.msec.2020.111839" @default.
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