Matches in SemOpenAlex for { <https://semopenalex.org/work/W3116516478> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W3116516478 endingPage "105035" @default.
- W3116516478 startingPage "105035" @default.
- W3116516478 abstract "Longevity gene klotho (KL) is associated with age-related phenotypes including lifespan, cardiometabolic disorders, cognition, and brain morphology, in part, by conferring protection against inflammation. We hypothesized that the KL/inflammation association might be altered in the presence of psychiatric stress and operate via epigenetic pathways. We examined KL polymorphisms, and their interaction with posttraumatic stress disorder (PTSD) symptoms, in association with KL DNA methylation in blood. We further examined KL DNA methylation as a predictor of longitudinal changes in a peripheral biomarker of inflammation (C-reactive protein; CRP).The sample comprised 309 white non-Hispanic military veterans (93.5 % male; mean age: 32 years, range: 19–65; 30 % PTSD per structured diagnostic interview); 111 were reassessed approximately two years later.Analyses revealed a methylation quantitative trait locus at rs9527025 (C370S, previously implicated in numerous studies of aging) in association with a Cytosine-phosphate-Guanine site (cg00129557; B = −.65, p = 1.29 X 10−20), located within a DNase hypersensitivity site in the body of KL. There was also a rs9527025 x PTSD severity interaction (B = .004, p = .035) on methylation at this locus such that the minor allele was associated with reduced cg00129557 methylation in individuals with few or no PTSD symptoms while this effect was attenuated in those with elevated levels of PTSD. Path models revealed that methylation at cg00129557 was inversely associated with CRP over time (B = −.14, p = .005), controlling for baseline CRP. There was also an indirect effect of rs9527025 X PTSD on subsequent CRP via cg00129557 methylation (indirect B = −.002, p = .033).Results contribute to our understanding of the epigenetic correlates of inflammation in PTSD and suggest that KL methylation may be a mechanism by which KL genotype confers risk vs. resilience to accelerated aging in those experiencing traumatic stress." @default.
- W3116516478 created "2021-01-05" @default.
- W3116516478 creator A5005067404 @default.
- W3116516478 creator A5033045880 @default.
- W3116516478 creator A5041259950 @default.
- W3116516478 creator A5043632685 @default.
- W3116516478 creator A5069553138 @default.
- W3116516478 creator A5072502595 @default.
- W3116516478 creator A5073332867 @default.
- W3116516478 creator A5091152947 @default.
- W3116516478 date "2020-09-01" @default.
- W3116516478 modified "2023-10-16" @default.
- W3116516478 title "Trajectories of body mass index and adolescent hair cortisol: importance of persistence, variability, and developmental timing" @default.
- W3116516478 doi "https://doi.org/10.1016/j.psyneuen.2020.105035" @default.
- W3116516478 hasPublicationYear "2020" @default.
- W3116516478 type Work @default.
- W3116516478 sameAs 3116516478 @default.
- W3116516478 citedByCount "0" @default.
- W3116516478 crossrefType "journal-article" @default.
- W3116516478 hasAuthorship W3116516478A5005067404 @default.
- W3116516478 hasAuthorship W3116516478A5033045880 @default.
- W3116516478 hasAuthorship W3116516478A5041259950 @default.
- W3116516478 hasAuthorship W3116516478A5043632685 @default.
- W3116516478 hasAuthorship W3116516478A5069553138 @default.
- W3116516478 hasAuthorship W3116516478A5072502595 @default.
- W3116516478 hasAuthorship W3116516478A5073332867 @default.
- W3116516478 hasAuthorship W3116516478A5091152947 @default.
- W3116516478 hasConcept C104317684 @default.
- W3116516478 hasConcept C126322002 @default.
- W3116516478 hasConcept C134018914 @default.
- W3116516478 hasConcept C135763542 @default.
- W3116516478 hasConcept C150194340 @default.
- W3116516478 hasConcept C180754005 @default.
- W3116516478 hasConcept C190727270 @default.
- W3116516478 hasConcept C2780221984 @default.
- W3116516478 hasConcept C2781197716 @default.
- W3116516478 hasConcept C33288867 @default.
- W3116516478 hasConcept C41091548 @default.
- W3116516478 hasConcept C54355233 @default.
- W3116516478 hasConcept C71924100 @default.
- W3116516478 hasConcept C84597430 @default.
- W3116516478 hasConcept C86803240 @default.
- W3116516478 hasConceptScore W3116516478C104317684 @default.
- W3116516478 hasConceptScore W3116516478C126322002 @default.
- W3116516478 hasConceptScore W3116516478C134018914 @default.
- W3116516478 hasConceptScore W3116516478C135763542 @default.
- W3116516478 hasConceptScore W3116516478C150194340 @default.
- W3116516478 hasConceptScore W3116516478C180754005 @default.
- W3116516478 hasConceptScore W3116516478C190727270 @default.
- W3116516478 hasConceptScore W3116516478C2780221984 @default.
- W3116516478 hasConceptScore W3116516478C2781197716 @default.
- W3116516478 hasConceptScore W3116516478C33288867 @default.
- W3116516478 hasConceptScore W3116516478C41091548 @default.
- W3116516478 hasConceptScore W3116516478C54355233 @default.
- W3116516478 hasConceptScore W3116516478C71924100 @default.
- W3116516478 hasConceptScore W3116516478C84597430 @default.
- W3116516478 hasConceptScore W3116516478C86803240 @default.
- W3116516478 hasLocation W31165164781 @default.
- W3116516478 hasOpenAccess W3116516478 @default.
- W3116516478 hasPrimaryLocation W31165164781 @default.
- W3116516478 hasRelatedWork W1698395555 @default.
- W3116516478 hasRelatedWork W1994614579 @default.
- W3116516478 hasRelatedWork W2157037706 @default.
- W3116516478 hasRelatedWork W2171278685 @default.
- W3116516478 hasRelatedWork W2355023196 @default.
- W3116516478 hasRelatedWork W2393464409 @default.
- W3116516478 hasRelatedWork W4220978054 @default.
- W3116516478 hasRelatedWork W4229068525 @default.
- W3116516478 hasRelatedWork W4283069558 @default.
- W3116516478 hasRelatedWork W4293795062 @default.
- W3116516478 hasVolume "119" @default.
- W3116516478 isParatext "false" @default.
- W3116516478 isRetracted "false" @default.
- W3116516478 magId "3116516478" @default.
- W3116516478 workType "article" @default.