FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3116618454> ?p ?o ?g. }

• W3116618454 endingPage "167" @default.
• W3116618454 startingPage "149" @default.
• W3116618454 abstract "Retinal ganglion cell (RGC) replacement holds potential for restoring vision lost to optic neuropathy. Transplanted RGCs must undergo neuroretinal integration to receive afferent visual signals for processing and efferent transmission. To date, retinal integration following RGC transplantation has been limited. We sought to overcome key barriers to transplanted human stem cell-derived RGC integration. Following co-culture ex vivo on organotypic mouse retinal explants, human RGCs cluster and extend bundled neurites that remain superficial to the neuroretina, hindering afferent synaptogenesis. To enhance integration, we increased the cellular permeability of the internal limiting membrane (ILM). Extracellular matrix digestion using proteolytic enzymes achieved ILM disruption while minimizing retinal toxicity and preserving glial reactivity. ILM disruption is associated with dispersion rather than clustering of co-cultured RGC bodies and neurites, and increased parenchymal neurite ingrowth. The ILM represents a significant obstacle to transplanted RGC connectivity and its circumvention may be necessary for functional RGC replacement." @default.
• W3116618454 created "2021-01-05" @default.
• W3116618454 creator A5010388452 @default.
• W3116618454 creator A5040841311 @default.
• W3116618454 creator A5042154323 @default.
• W3116618454 creator A5061410895 @default.
• W3116618454 creator A5061605698 @default.
• W3116618454 creator A5062820075 @default.
• W3116618454 creator A5072082254 @default.
• W3116618454 creator A5082931899 @default.
• W3116618454 date "2021-01-01" @default.
• W3116618454 modified "2023-10-17" @default.
• W3116618454 title "Role of the Internal Limiting Membrane in Structural Engraftment and Topographic Spacing of Transplanted Human Stem Cell-Derived Retinal Ganglion Cells" @default.
• W3116618454 cites W1579380203 @default.
• W3116618454 cites W1966040258 @default.
• W3116618454 cites W1977739438 @default.
• W3116618454 cites W1978711479 @default.
• W3116618454 cites W2002103394 @default.
• W3116618454 cites W2003437721 @default.
• W3116618454 cites W2003994112 @default.
• W3116618454 cites W2004538934 @default.
• W3116618454 cites W2008442745 @default.
• W3116618454 cites W2011634069 @default.
• W3116618454 cites W2019492982 @default.
• W3116618454 cites W2024846396 @default.
• W3116618454 cites W2031599833 @default.
• W3116618454 cites W2040848874 @default.
• W3116618454 cites W2048338614 @default.
• W3116618454 cites W2049763161 @default.
• W3116618454 cites W2049956106 @default.
• W3116618454 cites W2054859767 @default.
• W3116618454 cites W2057266151 @default.
• W3116618454 cites W2057502749 @default.
• W3116618454 cites W2070628315 @default.
• W3116618454 cites W2087238430 @default.
• W3116618454 cites W2087898838 @default.
• W3116618454 cites W2091698674 @default.
• W3116618454 cites W2104230245 @default.
• W3116618454 cites W2117547777 @default.
• W3116618454 cites W2128803651 @default.
• W3116618454 cites W2143550055 @default.
• W3116618454 cites W2143662575 @default.
• W3116618454 cites W2156303270 @default.
• W3116618454 cites W2160605010 @default.
• W3116618454 cites W2161258143 @default.
• W3116618454 cites W2161602638 @default.
• W3116618454 cites W2166068277 @default.
• W3116618454 cites W2166555967 @default.
• W3116618454 cites W2168599434 @default.
• W3116618454 cites W2261622256 @default.
• W3116618454 cites W2318035006 @default.
• W3116618454 cites W2326860902 @default.
• W3116618454 cites W2408411305 @default.
• W3116618454 cites W2409724652 @default.
• W3116618454 cites W2414627912 @default.
• W3116618454 cites W2460681702 @default.
• W3116618454 cites W2466697085 @default.
• W3116618454 cites W2495536352 @default.
• W3116618454 cites W2527991441 @default.
• W3116618454 cites W2528283452 @default.
• W3116618454 cites W2529404441 @default.
• W3116618454 cites W2537731554 @default.
• W3116618454 cites W2558470379 @default.
• W3116618454 cites W2561655264 @default.
• W3116618454 cites W2570769191 @default.
• W3116618454 cites W2614637757 @default.
• W3116618454 cites W2742311267 @default.
• W3116618454 cites W2745315781 @default.
• W3116618454 cites W2754493834 @default.
• W3116618454 cites W2761739377 @default.
• W3116618454 cites W2763984188 @default.
• W3116618454 cites W2770919798 @default.
• W3116618454 cites W2792623181 @default.
• W3116618454 cites W2794925059 @default.
• W3116618454 cites W2797212074 @default.
• W3116618454 cites W2804664596 @default.
• W3116618454 cites W2884599554 @default.
• W3116618454 cites W2884897477 @default.
• W3116618454 cites W2885724651 @default.
• W3116618454 cites W2893675751 @default.
• W3116618454 cites W2894302604 @default.
• W3116618454 cites W2904669625 @default.
• W3116618454 cites W2909156818 @default.
• W3116618454 cites W2915707868 @default.
• W3116618454 cites W2922322436 @default.
• W3116618454 cites W2943057288 @default.
• W3116618454 cites W2949625337 @default.
• W3116618454 cites W2956625420 @default.
• W3116618454 cites W3017177954 @default.
• W3116618454 cites W4247333492 @default.
• W3116618454 doi "https://doi.org/10.1016/j.stemcr.2020.12.001" @default.
• W3116618454 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7897583" @default.
• W3116618454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33382979" @default.
• W3116618454 hasPublicationYear "2021" @default.
• W3116618454 type Work @default.
• W3116618454 sameAs 3116618454 @default.
• W3116618454 citedByCount "33" @default.
• W3116618454 countsByYear W31166184542021 @default.

• next